STRINGSTRING
T1G11.9 T1G11.9 PTD PTD FIGL1 FIGL1 MSH2 MSH2 CDKA-1 CDKA-1 SOG1 SOG1 MPS1-2 MPS1-2 PCH2 PCH2 ML5 ML5 E2FA E2FA E2FB E2FB CYCA1-2 CYCA1-2 ML4 ML4 GIG1 GIG1 ML2 ML2 ML3-2 ML3-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
T1G11.9Holliday junction resolvase. (997 aa)
PTDProtein PARTING DANCERS; Required for chromosome segregation during meiosis. During diakinesis and prometaphase I, essential for the formation of class I meiotic crossovers and homologous recombination. Belongs to the ERCC1/RAD10/SWI10 family. (250 aa)
FIGL1ATPase family AAA domain-containing protein FIGL1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Limits class II meiotic crossover (CO) formation by regulating the invasion step of meiotic HR. May counteract DMC1 and RAD51-mediated inter-homolog strand invasion to limit CO formation. Functions independently of FANCM. Belongs to the AAA ATPase family. (680 aa)
MSH2DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2- MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti- recombination ef [...] (937 aa)
CDKA-1Cyclin-dependent kinase A-1; Involved in the control of the cell cycle. Essential for both G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis. Required to trigger guard mother cells (GMC) symmetric divisions at the late stage of stomatal development, probably via the regulation of G1 to S transition in the cell cycle. Required for the function of SPCH in entering the stomatal lineage. Promotes divisions in the guard cells (GCs) after the gu [...] (294 aa)
SOG1SUPPRESSOR OF GAMMA RESPONSE 1; Transcription factor regulating the transcriptional activation response to gamma irradiation. Required for stem-cell death induced by UVB or by gamma irradiation. Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases. Involved in DNA damage response (DDR) system that regulates cell cycle arrest. Functional homolog of animal p53. Regulates SMR5 and SMR7 transcription. Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. (449 aa)
MPS1-2Serine/threonine-protein kinase MPS1; Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication (By similarity). May be a downstream regulator of auxin signaling in the formation of secondary roots (Probable); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (777 aa)
PCH2Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination during meiosis. Mediates meiotic chromosome remodeling and crossover maturation. (467 aa)
ML5Protein MEI2-like 5; Probable RNA-binding protein that plays a role in meiosis and vegetative growth. (800 aa)
E2FATranscription factor E2FA; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. Belongs to the E2F/DP family. (485 aa)
E2FBTranscription factor E2FB; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. (469 aa)
CYCA1-2Cyclin-A1-2; Involved in the regulation of male meiosis progression. (442 aa)
ML4Protein MEI2-like 4; Probable RNA-binding protein that plays a role in meiosis and vegetative growth. (907 aa)
GIG1Protein GIGAS CELL1; Negative regulator of the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase required for proper mitotic and meiotic progression and cell fate determination. Involved in entry into both meiosis I and meiosis II. Prevents endomitosis by preferentially inhibiting APC/C(CDC20). Required for megagametophyte and endosperm development. Triggers mitotic cyclins (e.g. CYCB1-1 and CYCB1-2) accumulation. Confers immunity to bacterial pathogens (e.g. Pseudomonas syringae pv. tomato DC3000), which is associated with increased expression of disease resistance (R) gen [...] (243 aa)
ML2Protein MEI2-like 2; Probable RNA-binding protein that plays a role in meiosis and vegetative growth. (843 aa)
ML3-2Protein MEI2-like 3; Probable RNA-binding protein that plays a role in meiosis and vegetative growth. (759 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.