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NPR3 NPR3 TIFY5A TIFY5A OCP3 OCP3 TIFY4B TIFY4B TIFY8 TIFY8 TIFY4A TIFY4A NPR4 NPR4 TIFY6A TIFY6A MTP10 MTP10 NPR1 NPR1 ANS ANS JAZ7 JAZ7 MED16 MED16 JAZ13 JAZ13 SYD SYD WRKY11 WRKY11 NPR2 NPR2 GLYI4 GLYI4 WRKY70 WRKY70 TIFY6B TIFY6B JRG21 JRG21 TIFY3A TIFY3A PAD4 PAD4 TIFY10B TIFY10B WRKY46 WRKY46 F11B9.11 F11B9.11 WRKY53 WRKY53 LECRK19 LECRK19 TIFY10A TIFY10A ZAT18 ZAT18 TIFY11A TIFY11A ARR11 ARR11 MOP10.14 MOP10.14 MYB44 MYB44 TIFY11B TIFY11B PUB10 PUB10 TIFY3B TIFY3B TIFY9 TIFY9 WRKY54 WRKY54 TIFY7 TIFY7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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NPR3Regulatory protein NPR3; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens. (586 aa)
TIFY5AProtein TIFY 5A; Repressor of jasmonate responses. Unable to associate strongly with COI1 in the presence of jasmonoyl-isoleucine (JA-Ile) and is therefore more resistant to JA-mediated-degradation than other TIFY/JAZ proteins. Repress gene expression through direct recruitment of the corepressor TOPLESS to cognate transcription factors. (131 aa)
OCP3Protein OVEREXPRESSOR OF CATIONIC PEROXIDASE 3; May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity). Homeodomain transcription factor that mediates jasmonic acid (JA)-mediated COI1-dependent and abscisic acid (ABA)-mediated PMR4-dependent resistance to infection by necrotrophic fungal pathogens (e.g. B.cinerea and P.cucumerina) and bacterial pathogens (e.g. P.syringae DC3000); this resistance involves at least callose deposition. Required for the P.fluorescens WCS417r-triggered JA- dependent induced systemic resistance (ISR) against both P. [...] (354 aa)
TIFY4BProtein TIFY 4B; Regulates the arrest of dispersed meristematic cells during lamina development. (315 aa)
TIFY8Protein TIFY 8; Repressor of jasmonate responses. (361 aa)
TIFY4AProtein TIFY 4A; Regulates the arrest of dispersed meristematic cells during lamina development. (313 aa)
NPR4Regulatory protein NPR4; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. (574 aa)
TIFY6AProtein TIFY 6A; Repressor of jasmonate responses. Belongs to the TIFY/JAZ family. (310 aa)
MTP10Metal tolerance protein 10; Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (428 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
ANSProbable 2-oxoglutarate-dependent dioxygenase ANS; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. (353 aa)
JAZ7Protein TIFY 5B; Repressor of jasmonate responses. (148 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general [...] (1278 aa)
JAZ13Protein JAZ13; Non-TIFY functional repressor of jasmonate (JA)-mediated growth and defense responses. Intrinsically resistant to JA-induced turnover, probably due to the absence of the canonical degron that strongly interacts with COI1 in the presence of JA-Ile in the TIFY/JAZ proteins. (125 aa)
SYDChromatin structure-remodeling complex protein SYD; Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls stem cell fate via the transcription regulation of WUS in the shoot apical meristem, by modulating its promoter. LFY-dependent repressor of the meristem identity switch from vegetative to reproductive development probably by modulating chromatin state. Involved in the regulation of floral homeotic gene expression in response to environmental stimuli. Required for carpel and ovule d [...] (3574 aa)
WRKY11Probable WRKY transcription factor 11; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Regulates rhizobacterium B.cereus AR156-induced systemic resistance (ISR) to P.syringae pv. tomato DC3000, probably by activating the jasmonic acid (JA)- signaling pathway ; Belongs to the WRKY group II-d family. (325 aa)
NPR2Regulatory protein NPR2; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (600 aa)
GLYI4Lactoylglutathione lyase / glyoxalase I family protein. (174 aa)
WRKY70Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa)
TIFY6BProtein TIFY 6B; Repressor of jasmonate responses. Jasmonoyl-isoleucine (JA- Ile) specifically promotes COI1-TIFY6B/JAZ3 interaction. Acts as a negative regulator of MYC2 function. Feed-back regulated by MYC2. Belongs to the TIFY/JAZ family. (352 aa)
JRG21Probable 2-oxoglutarate-dependent dioxygenase JRG21; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. (363 aa)
TIFY3AProtein TIFY 3A; Repressor of jasmonate (JA) responses. Targets MYC2, MYC3 and MYC4 that are JA-dependent transcription activators. Belongs to the TIFY/JAZ family. (238 aa)
PAD4Lipase-like PAD4; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe- associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS-LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response to the fungal toxin fumo [...] (541 aa)
TIFY10BProtein TIFY 10B; Repressor of jasmonate responses. Jasmonoyl-isoleucine (JA- Ile) specifically promotes COI1-TIFY10B/JAZ2 interaction. Activated by MYC2, MYC3 and MYC4 transcription factors. Belongs to the TIFY/JAZ family. (249 aa)
WRKY46Probable WRKY transcription factor 46; Transcription factor involved in the regulation of osmotic stress responses and stomatal movement. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Positive regulator of EDS1-dependent defense against E.amylovora. Together with WRKY70 and WRKY53, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2. Together with WRKY54 and WRKY70, prom [...] (295 aa)
F11B9.11Probable 2-oxoglutarate-dependent dioxygenase At3g111800; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins. Belongs to the iron/ascorbate-dependent oxidoreductase family. (400 aa)
WRKY53Probable WRKY transcription factor 53; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. May regulate the early events of leaf senescence. Negatively regulates the expression of ESR/ESP. Together with WRKY46 and WRKY70, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2. Belongs to the WRKY group III family. (324 aa)
LECRK19L-type lectin-domain containing receptor kinase I.9; Essential receptor for extracellular ATP. Binds ATP with high affinity through its extracellular legume-lectin like region. Is required for ATP-induced intracellular calcium response, mitogen-activated protein kinase 3 (MPK3) and MPK6 activation and ATP-induced gene expression. May play a variety of roles in stress resistance. May be involved in protein-protein interactions with RGD motif-containing proteins as potential ligands. Plays probably a structural and signaling role at the plant cell surfaces. (766 aa)
TIFY10AProtein TIFY 10A; Repressor of jasmonate responses. Jasmonoyl-isoleucine (JA- Ile) specifically promotes COI1-TIFY10A/JAZ1 interaction. Interacts with COI1 and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. (253 aa)
ZAT18Zinc finger protein ZAT18; Transcription factor involved in stress responses (Probable). Positive regulator of the jasmonic acid (JA)- mediated signaling pathway. Triggers the up- regulation of LOX3, VSP2, PAL1 and PAL2 in a JA-dependent manner. Promotes drought and osmotic stress tolerance by preventing reactive oxygen species (ROS) production (e.g. H(2)O(2)). (175 aa)
TIFY11AProtein TIFY 11A; Repressor of jasmonate responses. (274 aa)
ARR11Two-component response regulator ARR11; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity); Belongs to the ARR family. Type-B subfamily. (521 aa)
MOP10.14Probable 2-oxoglutarate-dependent dioxygenase At5g05600; Involved in anthocyanin and protoanthocyanidin biosynthesis by catalyzing the oxidation of leucoanthocyanidins into anthocyanidins (By similarity). May be involved in the catabolism of cytotoxic polycyclic aromatic hydrocarbons (PAHs). Belongs to the iron/ascorbate-dependent oxidoreductase family. (371 aa)
MYB44Transcription factor MYB44; Transcription factor. Represses the expression of protein phosphatases 2C in response to abscisic acid (ABA). Confers resistance to abiotic stresses dependent of ABA. In response to auxin, activates the transcription of the auxin-responsive gene IAA19. The IAA19 transcription activation by MYB44 is enhanced by direct interaction between MYB44 and PYL8. Transcriptional activator of WRKY70 by direct binding to its promoter region, especially at 5'-TAACNG-3' and 5'-CNGTTA-3' symmetric motifs. Activates salicylic acid (SA)- mediated defenses and subsequent resis [...] (305 aa)
TIFY11BProtein TIFY 11B; Repressor of jasmonate responses. (269 aa)
PUB10U-box domain-containing protein 10; Functions as an E3 ubiquitin ligase. (628 aa)
TIFY3BProtein TIFY 3B; Repressor of jasmonate responses. (187 aa)
TIFY9Protein TIFY 9; Modulator of growth inhibition. Isoform 2 and isoform 3, but not isoform 1, confer a strong methyl-jasmonate insensitivity. Not involved in the growth response to salicylic acid or indole-3-acetic acid. Isoform 3 acts as an endogenous repressor of JA signal output in JA-stimulated cells ; Belongs to the TIFY/JAZ family. (197 aa)
WRKY54Probable WRKY transcription factor 54; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Together with WRKY70, negative regulator of developmental senescence, probably via the regulation of several senescence-associated markers genes. Positive regulator of EDS1-dependent defense against E.amylovora. In collaboration with WRKY70, prevents stomatal closure and, consequently, osmotic stress tolerance. Together with WRKY46 and WRKY70, promotes brassinosteroid (BR)- regulated plant [...] (346 aa)
TIFY7Protein TIFY 7; Repressor of jasmonate responses. Jasmonoyl-isoleucine (JA- Ile) specifically promotes COI1-TIFY7/JAZ9 interaction. Belongs to the TIFY/JAZ family. (267 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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