STRINGSTRING
ARP4 ARP4 F20P5.23 F20P5.23 HDA15 HDA15 F17A22.21 F17A22.21 MBD2 MBD2 F3I6.14 F3I6.14 ARP6 ARP6 HDA18 HDA18 YAK1 YAK1 HDC1 HDC1 HDA5 HDA5 F7G19.8 F7G19.8 TDX TDX ELM2 ELM2 A0A1P8BFD5 A0A1P8BFD5 F3I6.16 F3I6.16 ARID6 ARID6 F17L21.2 F17L21.2 F17L21.32 F17L21.32 F17L21.6 F17L21.6 T7N22.1 T7N22.1 F7G19.9 F7G19.9 F3I6.13 F3I6.13 F5O8.36 F5O8.36 T4M8.10 T4M8.10 SNL6 SNL6 SNL5 SNL5 WRKY19 WRKY19 F14N23.13 F14N23.13 SNL1 SNL1 MBD9 MBD9 T16K5.180 T16K5.180 T22E16.10 T22E16.10 HDA10 HDA10 MBD4 MBD4 F4IHD8_ARATH F4IHD8_ARATH HDA17 HDA17 Q9LK19_ARATH Q9LK19_ARATH SNL2 SNL2 F2G14.160 F2G14.160 ARID2 ARID2 F17L21.5 F17L21.5 T1K7.5 T1K7.5 MAF19.6 MAF19.6 HOS15 HOS15 RIN1 RIN1 HDA6 HDA6 K9I9.20 K9I9.20 MJE4.6 MJE4.6 SWC6 SWC6 TAF14B TAF14B HDA7 HDA7 F10D13.28 F10D13.28 ASHR3 ASHR3 HDA2 HDA2 HDA14 HDA14 ARID3 ARID3 HIP1 HIP1 SWC4 SWC4 T25N20.6 T25N20.6 SWC2 SWC2 T13L16.5 T13L16.5 F4J364_ARATH F4J364_ARATH F4JKT1_ARATH F4JKT1_ARATH F4JPL2_ARATH F4JPL2_ARATH F2G14.150 F2G14.150 SNL4 SNL4 F17L21.3 F17L21.3 F17L21.4 F17L21.4 HDA19 HDA19 MSI4 MSI4 ATXR3 ATXR3 SNL3 SNL3 F3I6.15 F3I6.15 F3I6.18 F3I6.18 SAP18 SAP18 SUVR5 SUVR5 HTR4 HTR4 CLF CLF ARID5 ARID5 MBD1 MBD1 PIE1 PIE1 ARID1 ARID1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ARP4Actin-related protein 4; Involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. (441 aa)
F20P5.23Paired amphipathic helix (PAH2) superfamily protein. (160 aa)
HDA15Histone deacetylase 15; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (552 aa)
F17A22.21Arginine-glutamic acid dipeptide repeat protein. (805 aa)
MBD2Methyl-CpG-binding domain-containing protein 2; Probable transcriptional regulator. (272 aa)
F3I6.14Paired amphipathic helix (PAH2) superfamily protein. (155 aa)
ARP6Actin-related protein 6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Binds to the promoter region of FLC chromatin. Required for the activation of FLC and FLC/MAF genes expression to levels that inhibit flowering, through both histone H3 and H4 acetylation and methylation mechanisms. Involved in several developmental processes including organization of plant organs, leaves formation, flowering time repression, and fertility. [...] (421 aa)
HDA18Histone deacetylase 18; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for appropriate cellular patterning in the root epidermis. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (682 aa)
YAK1Dual specificity protein kinase YAK1 homolog; Dual specificity protein kinase that phosphorylates ANN1, ANN2 and CP29B at serine and threonine residues, and ANN1, ANN2 and ANN4 at tyrosine residues. May regulate the phosphorylation status of annexin proteins. Acts as positive regulator in abscisic acid (ABA)-mediated regulation of postgermination growth and drought response. May regulate the expression of ABA-responsive genes such as RD22, RD29A, LTI65/RD29B and RAB18. (956 aa)
HDC1Zinc finger CCCH domain protein. (918 aa)
HDA5Histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (660 aa)
F7G19.8Arginine-glutamic acid dipeptide repeat protein. (916 aa)
TDXTPR repeat-containing thioredoxin TDX; Thiol-disulfide oxidoreductase that possesses insulin disulfide bonds reducing activity, disulfide reductase, foldase chaperone and holdase chaperone activities. Heat shock causes oligomerization and formation of high molecular weiht (HMW) complexes with concomitant functional switching from a disulfide reductase and foldase chaperone to a holdase chaperone. May interact with HSP70 proteins through the TPR repeats. (380 aa)
ELM2ELM2 domain-containing protein. (434 aa)
A0A1P8BFD5Paired amphipathic helix Sin3-like protein. (122 aa)
F3I6.16Paired amphipathic helix (PAH2) superfamily protein. (245 aa)
ARID6AT-rich interactive domain-containing protein 6; Belongs to the small heat shock protein (HSP20) family. (398 aa)
F17L21.2Paired amphipathic helix repeat-containing protein. (184 aa)
F17L21.32Paired amphipathic helix (PAH2) superfamily protein. (222 aa)
F17L21.6Paired amphipathic helix (PAH2) superfamily protein. (225 aa)
T7N22.1Uncharacterized protein. (915 aa)
F7G19.9Arginine-glutamic acid dipeptide repeat protein. (911 aa)
F3I6.13Paired amphipathic helix (PAH2) superfamily protein. (196 aa)
F5O8.36Paired amphipathic helix (PAH2) superfamily protein. (241 aa)
T4M8.10Putative MYB family transcription factor. (450 aa)
SNL6Paired amphipathic helix protein Sin3-like 6; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1173 aa)
SNL5Paired amphipathic helix protein Sin3-like 5; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1162 aa)
WRKY19Probable WRKY transcription factor 19; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. May act also as a disease resistance protein with a serine/threonine-protein kinase activity (By similarity). (1895 aa)
F14N23.13Paired amphipathic helix Sin3-like protein. (77 aa)
SNL1Paired amphipathic helix protein Sin3-like 1; Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability. (1372 aa)
MBD9Methyl-CpG-binding domain-containing protein 9; Probable transcriptional regulator that acts as a histone acetyltransferase. Mediates the acetylation of histone H3 and H4 of target loci (e.g. FLC). Involved in an auxin-independent regulation of shoot branching and flowering time. (2176 aa)
T16K5.180RuvB-like helicase; Belongs to the RuvB family. (473 aa)
T22E16.10Protein ALP1-like; Transposase-derived protein that may have nuclease activity. (406 aa)
HDA10Putative histone deacetylase 10; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (142 aa)
MBD4Methyl-CpG-binding domain-containing protein 4; Transcriptional regulator that binds CpG, CpNpN and CpNpG (N is A, T, or C) islands in promoters regardless the DNA methylation status. Plays probably a role in gene silencing. (186 aa)
F4IHD8_ARATHHistone deacetylase-like protein. (146 aa)
HDA17Histone deacetylase 17; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (158 aa)
Q9LK19_ARATHPaired amphipathic helix Sin3-like protein. (374 aa)
SNL2Paired amphipathic helix protein Sin3-like 2; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1367 aa)
F2G14.160Paired amphipathic helix (PAH2) superfamily protein. (87 aa)
ARID2AT-rich interactive domain-containing protein 2. (573 aa)
F17L21.5Paired amphipathic helix (PAH2) superfamily protein. (241 aa)
T1K7.5ELM2 domain protein. (493 aa)
MAF19.6Histone deacetylase-related / HD-like protein. (252 aa)
HOS15WD40 repeat-containing protein HOS15; Acts as repressor of cold stress-regulated gene expression. Interacts specifically with and promotes deacetylation of histone H4. Plays a role in gene regulation for plant acclimation and tolerance to cold stress. (613 aa)
RIN1RuvB-like protein 1; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Has single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). (458 aa)
HDA6Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this e [...] (471 aa)
K9I9.20RuvB-like helicase; Belongs to the RuvB family. (469 aa)
MJE4.6Paired amphipathic helix (PAH2) superfamily protein. (155 aa)
SWC6SWR1 complex subunit 6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Coodinates SWR1-C, FRI-C (FLC transcription activator complex), histone methyltransferase and general transcription factors. Represses flowering by positively regulating FLC and MAF4. Binds to the promoter region of FLC chromatin. (171 aa)
TAF14BTranscription initiation factor TFIID subunit 14b; Negative regulator of flowering controlling the H4K5 acetylation levels in the FLC and FT chromatin. Positively regulates FLC expression. Component of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of a NuA4 histone acetyltransferase complex which is involved in [...] (268 aa)
HDA7Histone deacetylase 7; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (409 aa)
F10D13.28Appr-1-p processing enzyme family protein. (562 aa)
ASHR3Histone-lysine N-methyltransferase ASHR3; Histone methyltransferase (By similarity). Involved in stamen development; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (497 aa)
HDA2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (387 aa)
HDA14Histone deacetylase 14; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (423 aa)
ARID3AT-rich interactive domain-containing protein 3. (786 aa)
HIP1FAM10 family protein At4g22670; Belongs to the FAM10 family. (441 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. (441 aa)
T25N20.6CDPK adapter, putative (DUF1423). (471 aa)
SWC2SWR1 complex subunit 2; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. (365 aa)
T13L16.5Phosphatidylinositol 3-and 4-kinase family protein with FAT domain-containing protein; Belongs to the PI3/PI4-kinase family. (3858 aa)
F4J364_ARATHUncharacterized protein. (1176 aa)
F4JKT1_ARATHHistone deacetylase. (70 aa)
F4JPL2_ARATHPhosphotransferases/inositol or phosphatidylinositol kinase; Belongs to the PI3/PI4-kinase family. (3834 aa)
F2G14.150Paired amphipathic helix Sin3-like protein. (139 aa)
SNL4Paired amphipathic helix protein Sin3-like 4; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1326 aa)
F17L21.3Paired amphipathic helix (PAH2) superfamily protein. (186 aa)
F17L21.4Paired amphipathic helix (PAH2) superfamily protein. (137 aa)
HDA19Histone deacetylase 19; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous flora [...] (501 aa)
MSI4WD-40 repeat-containing protein MSI4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the flowering autonomous pathway which positively regulates flowering by promoting transcriptional repression of the flowering repressor FLC. May promote histone deacetylation at the FLC locus leading to the formation of repressive chromatin structures. Also negatively regulates cold-responsive genes. (507 aa)
ATXR3Histone-lysine N-methyltransferase ATXR3; Histone methyltransferase specifically required for trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development. (2335 aa)
SNL3Paired amphipathic helix protein Sin3-like 3; Acts as a transcriptional repressor. Interacts with ERF7 to repress genes in abscisic acid and drought stress responses. The heterodimer represses transcription by tethering SNL3 to DNA. (1330 aa)
F3I6.15Paired amphipathic helix repeat-containing protein. (744 aa)
F3I6.18Paired amphipathic helix (PAH2) superfamily protein. (252 aa)
SAP18Histone deacetylase complex subunit SAP18; Links the histone deacetylase complex to transcriptional repressors bound to chromatin. Involved in the tethering of the SIN3 complex to core histone proteins. (152 aa)
SUVR5Histone-lysine N-methyltransferase SUVR5; Histone methyltransferase that functions together with its binding partner LDL1/SWP1 as one of the regulators of flower timing in Arabidopsis. Mediates H3K9me2 deposition and regulates gene expression in a DNA methylation-independent manner. Binds DNA through its zinc fingers and represses the expression of a subset of stimulus response genes. May represent a novel mechanism for plants to regulate their chromatin and transcriptional state, which may allow for the adaptability and modulation necessary to rapidly respond to environment or develop [...] (1382 aa)
HTR4Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
CLFHistone-lysine N-methyltransferase CLF; Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to regulate floral development by repressing the AGAMOUS homeotic gene in leaves, inflorescence stems and flowers. Together with ATX1, modulates AG nucleosome methylation statement. Regulates the antero-posterior organization of the endosperm, as well as the division and elongation rates of leaf cells. PcG proteins act by forming multiprotein complex [...] (902 aa)
ARID5AT-rich interactive domain-containing protein 5. (434 aa)
MBD1Methyl-CpG-binding domain-containing protein 1; Probable transcriptional regulator. (204 aa)
PIE1Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Probable DNA-dependent ATPase. Not involved in the repression of FLC in gametophytes, but required for the reactivation of FLC in early embryos and for the maintenance of full activation of FLC in late embryos. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (2055 aa)
ARID1AT-rich interactive domain-containing protein 1. (562 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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