STRINGSTRING
ATG7 ATG7 ATG1A ATG1A ATG8F ATG8F SH3P2 SH3P2 ATG8C ATG8C ATG8E ATG8E ATG8H ATG8H RBL18 RBL18 ATG9 ATG9 ATG8A ATG8A PRT1 PRT1 ATG16 ATG16 ATG3 ATG3 SINAT1 SINAT1 F27F23.15 F27F23.15 F4L23.23 F4L23.23 ATG101 ATG101 ATG1B ATG1B ATG13B ATG13B F4J0P2_ARATH F4J0P2_ARATH ATG1C ATG1C F4IL92_ARATH F4IL92_ARATH F2H15.22 F2H15.22 ARAC9 ARAC9 ATG8B ATG8B F27B13.90 F27B13.90 F19H22.120 F19H22.120 ATG11 ATG11 ATG8D ATG8D ATG13A ATG13A NBR1 NBR1 F3N23.33 F3N23.33 SINAT2 SINAT2 ATG8G ATG8G Q9LVP2_ARATH Q9LVP2_ARATH ATG8I ATG8I VAMP713 VAMP713 RBL20 RBL20
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ATG7Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing. (697 aa)
ATG1ASerine/threonine-protein kinase ATG1a; Serine/threonine protein kinase involved in autophagy in a nutritional condition-dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status. (626 aa)
ATG8FAutophagy-related protein 8f; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (121 aa)
SH3P2SH3 domain-containing protein 2; Regulator for autophaosome formation and/or maturation. Binds phosphatidylinositol 3-phosphate. (368 aa)
ATG8CAutophagy-related protein 8c; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton; Belongs to the ATG8 family. (119 aa)
ATG8EAutophagy-related protein 8e; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
ATG8HAutophagy-related protein 8h; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton; Belongs to the ATG8 family. (119 aa)
RBL18Rhomboid-like protein 18; Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis; Belongs to the peptidase S54 family. (287 aa)
ATG9Autophagy-related protein 9; Required for autophagy that plays an essential role in plant nutrient recycling. Contributes to efficient autophagic flux, especially in early autophagic process prior to the fusion of the autophagosome with the vacuole. Belongs to the ATG9 family. (866 aa)
ATG8AAutophagy-related protein 8a; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
PRT1E3 ubiquitin-protein ligase PRT1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Functions in the N-end rule pathway of protein degradation, where it specifically recognizes and ubiquitinates proteins with a N-terminal bulky aromatic amino acid (Phe). Does not act on aliphatic hydrophobic and basic N- terminal residues (Arg or Leu) containing proteins. (410 aa)
ATG16Autophagy-related protein 16; May play a role in autophagy. (509 aa)
ATG3Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. (313 aa)
SINAT1Putative E3 ubiquitin-protein ligase SINAT1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates (Probable). Mediates the proteasomal-dependent degradation of ATG6, a component of the autophagosome complex. Requires TRAF1A/MUSE14 and TRAF1B/MUSE13 to target ATG6 for ubiquitina [...] (305 aa)
F27F23.15Transmembrane protein (DUF872). (103 aa)
F4L23.23Myosin-4 protein (DUF641). (425 aa)
ATG101Autophagy-related protein 101; Accessory protein involved in autophagy. Acts as scaffold protein of the ATG1-ATG13 complex for faithful delivery of autophagic vesicles to the vacuole. Required for selective mitophagy. Belongs to the ATG101 family. (215 aa)
ATG1BSerine/threonine-protein kinase ATG1b; Serine/threonine protein kinase involved in autophagy. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. (711 aa)
ATG13BAutophagy-related protein 13b; Involved in autophagy in a nutritional condition dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation (By similarity). Connects autophagy to plant nutritional status. (625 aa)
F4J0P2_ARATHTransducin/WD40 repeat-like superfamily protein. (1614 aa)
ATG1CSerine/threonine-protein kinase ATG1c; Serine/threonine protein kinase involved in autophagy. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. (733 aa)
F4IL92_ARATHMucin. (170 aa)
F2H15.22Transmembrane protein. (263 aa)
ARAC9Rac-like GTP-binding protein ARAC9; Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation. (209 aa)
ATG8BAutophagy-related protein 8b; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
F27B13.90Transmembrane protein (DUF872). (103 aa)
F19H22.120SH3 domain-containing protein. (169 aa)
ATG11Autophagy-related protein 11; Accessory protein involved in autophagy. Acts as scaffold protein of the ATG1-ATG13 complex for faithful delivery of autophagic vesicles to the vacuole. Involved in the stress-induced phosphorylation of ATG1A for turnover of ATG1-ATG13 complex and proper ATG1-ATG13 complex assembly or activity. Required for selective mitophagy. Required for senescence-induced breakdown of mitochondria-resident proteins and mitochondrial vesicles. Seems not essential for ATG8- mediated autophagy; Belongs to the ATG11 family. (1148 aa)
ATG8DAutophagy-related protein 8d; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton; Belongs to the ATG8 family. (120 aa)
ATG13AAutophagy-related protein 13a; Involved in autophagy in a nutritional condition dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status. (603 aa)
NBR1Protein NBR1 homolog; Autophagic substrate degraded in the vacuole by non-selective autophagy. Requires ATG8 protein expression to be recognized as an autophagic substrate. Acts probably as a receptor for autophagosomal degradation of ubiquitinated proteins. Targets ubiquitinated protein aggregates derived from denatured or damaged non- native proteins generated under stress conditions. Functions additively with the E3 ubiquitin-protein ligase CHIP for autophagosomal degradation of proteotoxic aggregates formed under stress conditions. (704 aa)
F3N23.33F3N23.33 protein. (646 aa)
SINAT2E3 ubiquitin-protein ligase SINAT2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates (Probable). Mediates the proteasomal-dependent degradation of ATG6, a component of the autophagosome complex. Requires TRAF1A/MUSE14 and TRAF1B/MUSE13 to target ATG6 for ubiquitination and s [...] (308 aa)
ATG8GAutophagy-related protein 8g; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (121 aa)
Q9LVP2_ARATHTransmembrane protein (DUF872). (121 aa)
ATG8IAutophagy-related protein 8i; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (115 aa)
VAMP713Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane. (221 aa)
RBL20Rhomboid-like protein 20; Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis; Belongs to the peptidase S54 family. (293 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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