STRINGSTRING
A0A178V9P2 A0A178V9P2 A0A1I9LNY2 A0A1I9LNY2 B3H4L6_ARATH B3H4L6_ARATH OEP61 OEP61 F24J13.5 F24J13.5 F28C11.14 F28C11.14 F28C11.28 F28C11.28 F28C11.24 F28C11.24 F28C11.23 F28C11.23 F15K20.23 F15K20.23 F4J0F6_ARATH F4J0F6_ARATH F4J8X6_ARATH F4J8X6_ARATH F4JED3_ARATH F4JED3_ARATH P36 P36 PTM PTM TOC33 TOC33 OEP37 OEP37 TOC159 TOC159 MGD2 MGD2 PORB PORB OEP162 OEP162 OEP24A OEP24A FZL FZL F28C11.29 F28C11.29 F28C11.33 F28C11.33 AKR2B AKR2B TOC34 TOC34 EARLI1 EARLI1 TOC75-4 TOC75-4 P39 P39 ARC3 ARC3 OEP21A OEP21A TOC90 TOC90 K15N18.17 K15N18.17 ARC5 ARC5 T4M8.14 T4M8.14 OEP24B OEP24B TGD1 TGD1 SP1 SP1 F10M6.110 F10M6.110 DGD2 DGD2 SFR2 SFR2 KO KO TIM22-2 TIM22-2 F5O8.19 F5O8.19 OEP161 OEP161 F5O8.8 F5O8.8 F5O8.12 F5O8.12 OEP80 OEP80 RER2 RER2 F5O8.16 F5O8.16 CB5-A CB5-A CRL CRL PDV1 PDV1 OEP21B OEP21B F23O10.17 F23O10.17 CHUP1 CHUP1 F21F23.16 F21F23.16 TOC120 TOC120 OEP64 OEP64 F16M2_10 F16M2_10 T22E16.200 T22E16.200 TGD4 TGD4 DGD1 DGD1 AKR2A AKR2A MGD3 MGD3 THF1 THF1 TOC132 TOC132 TOC75-3 TOC75-3 T1P17.90 T1P17.90 T1P17.80 T1P17.80 AZI1 AZI1 F4F15.340 F4F15.340 OEP7 OEP7 PDV2 PDV2 F5O8.24 F5O8.24 F5O8.22 F5O8.22 F5O8.20 F5O8.20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A178V9P2Nuclear transport factor 2 family protein. (132 aa)
A0A1I9LNY2Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like protein. (167 aa)
B3H4L6_ARATHUncharacterized protein. (74 aa)
OEP61Outer envelope protein 61; Plays a role in protein import into the endoplasmic reticulum (ER). May function as chaperone docking protein during post- translational protein translocation into the ER. Chaperone receptor mediating Hsp70-dependent protein targeting to chloroplasts. Interacts specifically with some chloroplast precursors, but not with mitochondrial precursors. Able to select precursors for delivery to the chloroplast translocase independently of Hsp70. (554 aa)
F24J13.5OBP32pep, putative (DUF220). (338 aa)
F28C11.14OBP32pep protein. (192 aa)
F28C11.28Uncharacterized protein. (216 aa)
F28C11.24Uncharacterized protein. (78 aa)
F28C11.23Uncharacterized protein. (264 aa)
F15K20.23Uncharacterized protein. (293 aa)
F4J0F6_ARATHSerine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit. (492 aa)
F4J8X6_ARATHannotation not available (587 aa)
F4JED3_ARATHRNA-binding (RRM-RBD-RNP motif) domain nuclear transport factor 2 family protein. (677 aa)
P36Outer envelope protein 36, chloroplastic; May play a role during plastid development. Belongs to the OEP80 (TC 1.B.33.2) family. (321 aa)
PTMDDT domain-containing protein PTM; Membrane-bound transcription factor required for the plastid- to-nucleus retrograde signaling. Functions in multiple retrograde pathways. The plastid-to-nucleus signal plays an important role in the coordinated expression of both nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins. In the nucleus, activates ABI4 transcription in a PHD-dependent manner associated with histone modifications. Localized primarily in the chloroplast outer membrane as dormant form and, in response to retrograde signals, is released from the [...] (1706 aa)
TOC33Translocase of chloroplast 33, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Binds GTP, GDP, XTP, but not ATP. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast, especially during early development stages. (297 aa)
OEP37Outer envelope pore protein 37, chloroplastic; Voltage-dependent peptide-sensitive high conductance rectifying cation channel with a strong affinity for TIC32 that is imported into the chloroplast. Conductance is pH-dependent decreasing with decreasing pH values; Belongs to the plastid outer envelope porin OEP37 (TC 1.B.47) family. (343 aa)
TOC159Translocase of chloroplast 159, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Required for chloroplast biogenesis. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. TOC159 subfamily. (1503 aa)
MGD2Monogalactosyldiacylglycerol synthase 2, chloroplastic; Involved in the synthesis of the major structural component of photosynthetic membranes and in the chloroplast envelope biogenesis. Can use both prokaryotic (18:1/16:0) or eukaryotic (18:2/18:2) 1,2- diacylglycerol species, but operates with some preference for the eukaryotic one; Belongs to the glycosyltransferase 28 family. (468 aa)
PORBProtochlorophyllide reductase B, chloroplastic; Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide); Belongs to the short-chain dehydrogenases/reductases (SDR) family. POR subfamily. (401 aa)
OEP162Outer envelope pore protein 16-2, chloroplastic; Voltage-dependent high-conductance channel with a slight cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars (By similarity). Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB. (178 aa)
OEP24AOuter envelope pore protein 24A, chloroplastic; High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids; Belongs to the plastid outer envelope porin OEP24 (TC 1.B.28) family. (213 aa)
FZLProbable transmembrane GTPase FZO-like, chloroplastic; Probable membrane-remodeling GTPase that plays a unique role in the in the determination of thylakoid and chloroplast morphology and regulates organization of the thylakoid network. Not involved in the determination of mitochondrial morphology or ultrastructure. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (912 aa)
F28C11.29Uncharacterized protein. (217 aa)
F28C11.33Uncharacterized protein. (263 aa)
AKR2BAnkyrin repeat domain-containing protein 2B; Exhibits chaperone activity toward chloroplast outer envelope membrane, mitochondrion outer membrane, endoplasmic reticulum membrane and peroxisomal proteins, by recruiting specific proteins containing a single transmembrane associated with an AKR2A-binding sequence (ABS) and subsequently binding glycolipids (e.g. monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG)) present in the membrane of the target organelle. (344 aa)
TOC34Translocase of chloroplast 34, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast. (313 aa)
EARLI1Lipid transfer protein EARLI 1; Probable lipid transfer protein (LTP). May improve freezing survival. Seems to control the flowering process and lignin synthesis. Has an auxiliary role for germinability and early seedling development under low temperature and salt stress conditions, probably in an abscisic acid- (ABA) dependent manner. Confers resistance to Botrytis cinerea and exhibits anti-fungal activity, at least against S.cerevisiae, B. cinerea and Fusarium oxysporum, probably by increasing their membrane permeability. Belongs to the plant LTP family. PEARLI1 subfamily. (168 aa)
TOC75-4Protein TOC75-4, chloroplastic; Mediates the insertion of proteins targeted to the outer membrane of chloroplasts. Required for the import of protein precursors into chloroplasts. Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane (By similarity). Required for etioplast formation and/or etioplast-chloroplast transition during deetiolation. (396 aa)
P39Outer envelope protein 39, chloroplastic; Beta-barrel pore-forming protein which possesses voltage- dependent channel activity. Required for proper plastid development. Involved in the maintenance of metabolic homeostasis of full-grown plants. Belongs to the OEP80 (TC 1.B.33.2) family. (362 aa)
ARC3Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 3; Z-ring accessory protein involved in the initiation of plastid division and division site placement (might functionally replace bacterial MinC). May control the rate of chloroplast expansion. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency. (741 aa)
OEP21AOuter envelope pore protein 21A, chloroplastic; Voltage-dependent rectifying anion channel that facilitates the translocation between chloroplast and cytoplasm of phosphorylated carbohydrates such as triosephosphate, 3-phosphoglycerate and inorganic phosphate (Pi) depending of ATP to triosephosphate ratio in the plastidial intermembrane space; in high triosephosphate/ATP conditions (e.g. photosynthesis), export of triosphosphate from chloroplast (outward rectifying channels), but in high ATP/triosephosphate conditions (e.g. dark phase), import of phosphosolutes (inward rectifying chann [...] (167 aa)
TOC90Translocase of chloroplast 90, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded photosynthetic preproteins from the cytoplasm to the chloroplast. (793 aa)
K15N18.17Putative NTF2-containing RNA-binding protein. (458 aa)
ARC5Dynamin-like protein ARC5; Probable GTPase component of both plastid and peroxisme division machinery. Required for the last steps of plastid division specifically in mesophyll-cell, when the narrow isthmus breaks, facilitating the separation of the daughter plastids. Necessary for peroxisome activities. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (777 aa)
T4M8.14Ankyrin repeat family protein. (240 aa)
OEP24BOuter envelope pore protein 24B, chloroplastic; High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids. (213 aa)
TGD1Protein TRIGALACTOSYLDIACYLGLYCEROL 1, chloroplastic; Required during embryogenesis. Permease involved in lipid transfer from the endoplasmic reticulum (ER) to plastids, and necessary for thylakoids formation. (350 aa)
SP1E3 ubiquitin-protein ligase SP1; E3 ubiquitin-protein ligase involved in the regulation of protein import in the chloroplast. Associates with TOC complexes and mediates ubiquitination of TOC components, promoting their degradation via the ubiquitin-proteasome system (UPS). Plays a role in the reorganization of the TOC machinery. Involved in a mechanism that regulates plastid biogenesis via UPS. Promotes stress tolerance by depleting the chloroplast protein import apparatus, which limits photosystem assembly and the potential for reactive oxygen species (ROS) formation. May act as negat [...] (343 aa)
F10M6.110Protein kinase superfamily protein. (611 aa)
DGD2Digalactosyldiacylglycerol synthase 2, chloroplastic; Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes. Specific for alpha- glycosidic linkages. During phosphate shortage, involved in the biosynthesis of digalactosyldiacylglycerol (DGDG) which rescues the limitation of phospholipids (Probable); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (473 aa)
SFR2Galactolipid galactosyltransferase SFR2, chloroplastic; Glycosyl hydrolase family protein acting primarily as a highly specific galactosyltransferase. Synthesizes digalactosyldiacylglycerol from monogalactosyldiacylglycerol in the absence of UDP-galactose in vitro. Hydrolyzes o- and p-nitrophenyl beta-D-glucoside in vitro. Plays a role in freezing tolerance. May play a role in chloroplast protection. (622 aa)
KOEnt-kaurene oxidase, chloroplastic; Catalyzes three successive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid, a key step in gibberellins (GAs) biosynthesis. GAs, which are involved many processes, including stem elongation, play a central role in plant development. (509 aa)
TIM22-2Chloroplastic import inner membrane translocase subunit TIM22-2; Together with HP30-1 and HP30-2, triggers the import and insertion of transit sequence-less multi-pass transmembrane proteins (e.g. CEQORH) into the chloroplastic inner membrane. Belongs to the Tim17/Tim22/Tim23 family. (210 aa)
F5O8.19OBP32pep protein. (264 aa)
OEP161Outer envelope pore protein 16-1, chloroplastic; Voltage-dependent high-conductance channel with a slight cation-selectivity; selective for amino acids but excludes triosephosphates or uncharged sugars (By similarity). Non-essential amino acid-selective channel protein and translocation pore for NADPH:protochlorophyllide oxidoreductase A (PORA) and possibly PORB. Involved in PORA precursor (pPORA) import and thus confers photoprotection onto etiolated seedlings during greening. (148 aa)
F5O8.8F5O8.8 protein. (263 aa)
F5O8.12OBP32pep, putative (DUF220). (332 aa)
OEP80Outer envelope protein 80, chloroplastic; Plays an essential role during early stages of plastid development; Belongs to the OEP80 (TC 1.B.33.2) family. (732 aa)
RER2Protein RETICULATA-RELATED 2, chloroplastic; May play a role in leaf development. Belongs to the RETICULATA family. (339 aa)
F5O8.16Expressed protein. (270 aa)
CB5-ACytochrome b5 isoform A; Belongs to the cytochrome b5 family. (135 aa)
CRLChromophore lyase CRL, chloroplastic; Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity). Required for plastid division, and involved in cell differentiation and regulation of the cell division plane. Maintenance of plastid homeostasis controls plant preconditioning to stress and stress acclimation. Belongs to the CpcT/CpeT biliprotein lyase family. (269 aa)
PDV1Plastid division protein PDV1; Component of the plastid division machinery. Required to mediate the recruitment of ARC5 at the midplastid constriction site in the cytoplasm. (272 aa)
OEP21BOuter envelope pore protein 21B, chloroplastic; Voltage-dependent rectifying anion channel that facilitates the translocation between chloroplast and cytoplasm of phosphorylated carbohydrates such as triosephosphate, 3-phosphoglycerate and inorganic phosphate (Pi) depending of ATP to triosephosphate ratio in the plastidial intermembrane space; in high triosephosphate/ATP conditions (e.g. photosynthesis), export of triosphosphate from chloroplast (outward rectifying channels), but in high ATP/triosephosphate conditions (e.g. dark phase), import of phosphosolutes (inward rectifying chann [...] (167 aa)
F23O10.17Putative RNA-binding protein; 63745-61607. (427 aa)
CHUP1Protein CHUP1, chloroplastic; Required for the positioning and movement of chloroplasts. Interacts with profilin and actin independent of its polymerization status. Regulates chloroplast localization by anchoring chloroplasts to the plasma membrane and forming a bridge to the actin cytoskeleton. (1004 aa)
F21F23.16At1g13730/F21F23_12. (428 aa)
TOC120Translocase of chloroplast 120, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. TOC159 subfamily. (1089 aa)
OEP64Outer envelope protein 64, chloroplastic; Chaperone receptor mediating Hsp90-dependent protein targeting to chloroplasts. Bi-functional preprotein receptor acting on both sides of the membrane. Not essential for an efficient import of pre-proteins into plastids. (589 aa)
F16M2_10Chloroplast outer envelope membrane protein. (69 aa)
T22E16.200Nuclear transport factor 2 (NTF2) family protein. (334 aa)
TGD4Protein TRIGALACTOSYLDIACYLGLYCEROL 4, chloroplastic; Involved in lipid transfer from the endoplasmic reticulum (ER) to plastids. Specifically binds phosphatidic acid (PtdOH). (479 aa)
DGD1Digalactosyldiacylglycerol synthase 1, chloroplastic; Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes. Specific for alpha- glycosidic linkages. Responsible for the final assembly of galactolipids in photosynthetic membranes. Digalactosyldiacylglycerol (DGDG) provides stability to the photosystem I (PSI) complex, especially to the PsaA, PsaB, PsaC, PsaL and PsaH subunits. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (808 aa)
AKR2AAnkyrin repeat domain-containing protein 2A; Exhibits chaperone activity toward chloroplast outer envelope membrane, mitochondrion outer membrane, endoplasmic reticulum membrane and peroxisomal proteins, by recruiting specific proteins containing a single transmembrane associated with an AKR2A-binding sequence (ABS) and subsequently binding glycolipids (e.g. monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG)) present in the membrane of the target organelle. Seems to be involved in the regulation of hydrogen peroxide levels during biotic and abiotic stresses by optimizing [...] (342 aa)
MGD3Monogalactosyldiacylglycerol synthase 3, chloroplastic; Involved in the synthesis of the major structural component of photosynthetic membranes and in the chloroplast envelope biogenesis. Can use both prokaryotic (18:1/16:0) or eukaryotic (18:2/18:2) 1,2- diacylglycerol species, but operates with some preference for the eukaryotic one. (465 aa)
THF1Protein THYLAKOID FORMATION 1, chloroplastic; Involved in a dynamic process of vesicle-mediated thylakoid membrane biogenesis. Required for the normal organization of vesicles into mature thylakoid stacks and ultimately for leaf development. Also involved in a sugar-signaling mechanism in roots by mediating signaling between the plasma membrane and the plastid. Probably acts downstream of the plasma membrane-delimited heterotrimeric G-protein GPA1 in a D- glucose signaling pathway; Belongs to the THF1 family. (300 aa)
TOC132Translocase of chloroplast 132, chloroplastic; GTPase involved in protein precursor import into chloroplasts. Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis. Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast. (1206 aa)
TOC75-3Protein TOC75-3, chloroplastic; Essential protein. Mediates the insertion of proteins targeted to the outer membrane of chloroplasts (By similarity). Required for the import of protein precursors into chloroplasts. Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane. (818 aa)
T1P17.90pEARLI1-like lipid transfer protein 3; Probable lipid transfer protein (LTP). May improve freezing survival. (177 aa)
T1P17.80pEARLI1-like lipid transfer protein 2; Probable lipid transfer protein (LTP). May improve freezing survival. Seems to control the flowering process and lignin synthesis. Confers resistance to Botrytis cinerea; Belongs to the plant LTP family. PEARLI1 subfamily. (182 aa)
AZI1pEARLI1-like lipid transfer protein 1; Probable lipid transfer protein (LTP). Seems to control the flowering process and lignin synthesis. Together with DIR1, required for glycerol-3-phosphate- (G3P) and azelaic acid- (AA) induced systemic acquired resistance (SAR). Component of plant systemic immunity involved in priming defenses in a AA-dependent manner, by modulating production and/or translocation of a mobile signal(s) during SAR. Confers resistance to Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000 and PmaDG3. May be involved in induced systemic resistance (ISR) mediat [...] (161 aa)
F4F15.340AT3g52230/F4F15_340. (145 aa)
OEP7Outer envelope membrane protein 7. (64 aa)
PDV2Plastid division protein PDV2; Component of the plastid division machinery. Required to mediate the recruitment of ARC5 at the midplastid constriction site in the cytoplasm. Relays plastid division site position between stroma and outer surface via interactions with the cytoplasmic ARC5 and the inner membrane ARC6 that recruits stromal FtsZ ring. (307 aa)
F5O8.24Expressed protein. (273 aa)
F5O8.22OBP32pep protein, putative (DUF220). (264 aa)
F5O8.20F5O8.20 protein. (225 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (14%) [HD]