STRINGSTRING
K24G6.2 K24G6.2 RAD23D RAD23D RAD23C RAD23C RAD23A RAD23A RAD23B RAD23B UPL1 UPL1 UPL2 UPL2 UBP14 UBP14 RBL15 RBL15 K19E1.13 K19E1.13 RBL18 RBL18 UBC27 UBC27 KIN12 KIN12 T15N1.30 T15N1.30 F4P13.11 F4P13.11 T21H19.10 T21H19.10 MXC9.8 MXC9.8 RECQSIM RECQSIM RBL20 RBL20 DRM1-2 DRM1-2 DRM2 DRM2 F13M7.16 F13M7.16 DSK2B DSK2B DSK2A DSK2A OTU6 OTU6 F3I6.23 F3I6.23 F12C20.4 F12C20.4 KIN11 KIN11 DDI1 DDI1 KIN10 KIN10 NUB1 NUB1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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K24G6.2Ubiquitin-associated (UBA)/TS-N domain protein. (323 aa)
RAD23DUbiquitin receptor RAD23d; May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (By similarity); Belongs to the RAD23 family. (378 aa)
RAD23CUbiquitin receptor RAD23c; May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). (419 aa)
RAD23AProbable ubiquitin receptor RAD23a; May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP) (By similarity); Belongs to the RAD23 family. (368 aa)
RAD23BUbiquitin receptor RAD23b; May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP); Belongs to the RAD23 family. (371 aa)
UPL1E3 ubiquitin-protein ligase UPL1; Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. (3681 aa)
UPL2E3 ubiquitin-protein ligase UPL2; Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. (3658 aa)
UBP14Ubiquitin carboxyl-terminal hydrolase 14; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Involved in seed and embryo development. (797 aa)
RBL15Rhomboid-like protein 15; Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. May function in senescence. (403 aa)
K19E1.13Ubiquitin-associated/translation elongation factor EF1B protein. (221 aa)
RBL18Rhomboid-like protein 18; Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis; Belongs to the peptidase S54 family. (287 aa)
UBC27Ubiquitin-conjugating enzyme E2 27; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (192 aa)
KIN12SNF1-related protein kinase catalytic subunit alpha KIN12; Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, a central regulator of cellular energy homeostasis, which, in response to seemingly unrelated darkness, sugar and stress conditions, activates energy-producing pathways and inhibits energy-consuming processes. May also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase. (494 aa)
T15N1.30Basic salivary proline-rich-like protein (DUF1421). (547 aa)
F4P13.11Proline-rich receptor-like kinase, putative (DUF1421). (511 aa)
T21H19.10RAD23 UV excision repair family protein. (171 aa)
MXC9.8Ubiquitin-associated/translation elongation factor EF1B protein. (619 aa)
RECQSIMATP-dependent DNA helicase Q-like SIM; Plant specific 3'-5' DNA helicase that may play a role in the repair of DNA. (858 aa)
RBL20Rhomboid-like protein 20; Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis; Belongs to the peptidase S54 family. (293 aa)
DRM1-2DNA (cytosine-5)-methyltransferase DRM1; Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. DRM-methyltransferase family. (624 aa)
DRM2DNA (cytosine-5)-methyltransferase DRM2; Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation (RdDM). Acts as major DNA methyltransferase in the RdDM pathway, and is essential for RNA-directed de novo DNA methylation of cytosines in all sequence contexts. Associates with long non- coding RNA (lncRNA) produced by RNA polymerase V (Pol V). This association is dependent on AGO4 [...] (626 aa)
F13M7.16Ubiquitin-associated (UBA)/TS-N domain-containing protein. (413 aa)
DSK2BUbiquitin domain-containing protein DSK2b; Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). (551 aa)
DSK2AUbiquitin domain-containing protein DSK2a; Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). (538 aa)
OTU6OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 6; Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Binds chromatin (e.g. nucleosomes and histones) and has enzymatic histone deubiquitinase activity, specific for the H2B histone. Can both repress (e.g. OSR2) and promote (e.g. AN3) the expression of target genes by associating with chromatin, deubiquitinating H2B and regulating its euchromatic histone marks (e.g. H3ac and H3K4me). In association wit [...] (505 aa)
F3I6.23AAA-type ATPase family protein. (525 aa)
F12C20.4Ubiquitin-associated/translation elongation factor EF1B protein. (646 aa)
KIN11SNF1-related protein kinase catalytic subunit alpha KIN11; Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, a central regulator of cellular energy homeostasis, which, in response to seemingly unrelated darkness, sugar and stress conditions, activates energy-producing pathways and inhibits energy-consuming processes. May play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA c [...] (512 aa)
DDI1Protein DNA-DAMAGE INDUCIBLE 1; Receptor of ubiquitinated protein targeted to ubiquitin/proteasome-mediated proteolysis (UPP). Relatively weak affinity for both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains with a slight preference for 'Lys-48-'linked chains of three or more ubiquitin units. (414 aa)
KIN10SNF1-related protein kinase catalytic subunit alpha KIN10; Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, a central regulator of cellular energy homeostasis, which, in response to seemingly unrelated darkness, sugar and stress conditions, activates energy-producing pathways and inhibits energy-consuming processes. May play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA c [...] (512 aa)
NUB1Ubiquitin-associated (UBA)/TS-N domain-containing protein. (562 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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