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| | JHS1 | DNA replication ATP-dependent helicase/nuclease JHS1; Essential protein required during embryogenesis. Key enzyme involved in DNA replication and damage repair, shoot apical meristem (SAM) maintenance, and development. Involved in Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)- dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load [...] (1331 aa) |
| | F4HNV0_ARATH | Endonuclease/glycosyl hydrolase. (143 aa) |
| | F4HSA3_ARATH | Putative endonuclease or glycosyl hydrolase. (228 aa) |
| | POLIA | DNA polymerase I A, chloroplastic/mitochondrial; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria. May be required for DNA repair in both organelles; Belongs to the DNA polymerase type-A family. (1050 aa) |
| | PTD | Protein PARTING DANCERS; Required for chromosome segregation during meiosis. During diakinesis and prometaphase I, essential for the formation of class I meiotic crossovers and homologous recombination. Belongs to the ERCC1/RAD10/SWI10 family. (250 aa) |
| | CAN2 | Staphylococcal-like nuclease CAN2; Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond. Possesses activity toward the single-stranded DNA, double-stranded DNA and RNA. May be involved in genomic DNA degradation during programmed cell death. (332 aa) |
| | F17H15.6 | Exonuclease 3'-5' domain-containing protein 1. (342 aa) |
| | RNE | Ribonuclease E/G-like protein, chloroplastic; Involved in intercistronic processing of primary transcripts from chloroplast operons. The endonucleolytic activity of the enzyme depends on the number of phosphates at the 5' end, is inhibited by structured RNA, and preferentially cleaves A/U-rich sequences. Belongs to the RNase E/G family. (1001 aa) |
| | CAN1 | Staphylococcal-like nuclease CAN1; Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond. Possesses activity toward the single-stranded DNA, double-stranded DNA and RNA. May be involved in genomic DNA degradation during programmed cell death. (323 aa) |
| | F4J0R7_ARATH | Putative endonuclease or glycosyl hydrolase. (172 aa) |
| | TRZ4 | tRNAse Z TRZ4, mitochondrial; Zinc phosphodiesterase, which displays tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'- trailer from precursor tRNA. Can process the mitochondrial tRNA-like structures (t-elements). (942 aa) |
| | F11A12.6 | tRNA-splicing endonuclease subunit. (205 aa) |
| | F4JC91_ARATH | Putative endonuclease or glycosyl hydrolase. (383 aa) |
| | F4JD16_ARATH | C2 calcium/lipid-binding endonuclease/exonuclease/phosphatase. (627 aa) |
| | F4JD25_ARATH | Putative endonuclease or glycosyl hydrolase. (254 aa) |
| | NEN4 | Protein NEN4; Probable exonuclease required for enuclation of sieve elements. (255 aa) |
| | ENDO4 | Endonuclease 4; Endonuclease that can use single-stranded RNA and DNA as substrates. In contradiction with cannot hydrolyze single-stranded DNA and does not cleave mismatches. (299 aa) |
| | ENDO5 | Endonuclease 5; Hydrolyzes, with low efficiency, only single-stranded DNA and RNA without apparent specificity for bases. Endonuclease that recognizes and cleaves some mismatches with high efficiency, including heteroduplex double-stranded DNA; mostly efficient on T/G, A/G and G/G mismatches, less efficient for T/T and poorly efficient for C/C, A/A, T/C and A/C. (296 aa) |
| | PRORP3 | Proteinaceous RNase P 3; Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA); Belongs to the PPR family. P subfamily. (576 aa) |
| | F4JN57_ARATH | DDE family endonuclease. (527 aa) |
| | APE2 | DNA-(apurinic or apyrimidinic site) lyase 2; Exhibits apurinic/apyrimidinic (AP) endonuclease activity in vitro. By contrast, another report show that APE2 has no biochemical activity. Unable to catalyze the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH. Has no in vitro 3'- phosphatase activity. Redundant with APE1L and at least one functional allele is required for seed viability. Has a strong non-specific affinity to DNA. (610 aa) |
| | MORC3 | Protein MICRORCHIDIA 3; Exhibits ATPase activity. Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair. Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing. May also be involved in the regulation of chromatin architecture to maintain gene silencing. (589 aa) |
| | MORC7 | Protein MICRORCHIDIA 7; Exhibits ATPase activity. Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair. Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing. May also be involved in the regulation of chromatin architecture to maintain gene silencing. Together with MORC4, acts to suppress a wide set of non- methylated protein-coding genes, especially involved in pathogen response. Positive regulators of defense against the oomycete Hyaloperonospora arabidopsidis (Hpa). (707 aa) |
| | MJE4.10 | Putative endonuclease or glycosyl hydrolase. (192 aa) |
| | MAF19.18 | Putative endonuclease or glycosyl hydrolase. (374 aa) |
| | MORC5 | Protein MICRORCHIDIA 5; Exhibits ATPase activity. Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair. Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing. May also be involved in the regulation of chromatin architecture to maintain gene silencing. (708 aa) |
| | MXM12.5 | annotation not available (1194 aa) |
| | MORC4 | Protein MICRORCHIDIA 4; Exhibits ATPase activity. Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair. Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing. May also be involved in the regulation of chromatin architecture to maintain gene silencing. Together with MORC7, acts to suppress a wide set of non- methylated protein-coding genes, especially involved in pathogen response. Positive regulator of defense against the oomycete Hyaloperonospora arabidopsidis (Hpa). (800 aa) |
| | MIJ24.14 | Putative endonuclease or glycosyl hydrolase. (76 aa) |
| | MKM21.10 | Restriction endonuclease, type II-like superfamily protein. (1272 aa) |
| | CAF1-5 | Probable CCR4-associated factor 1 homolog 5; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (278 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (383 aa) |
| | F1E22.12-2 | Putative ribonuclease H protein At1g65750. (620 aa) |
| | RNS1 | Ribonuclease 1; May remobilize phosphate, particularly when cells senesce or when phosphate becomes limiting. (230 aa) |
| | RNS2 | Ribonuclease 2; May remobilize phosphate, particularly when cells senesce or when phosphate becomes limiting. (259 aa) |
| | RNS3 | Ribonuclease 3; May remobilize phosphate, particularly when cells senesce or when phosphate becomes limiting; Belongs to the RNase T2 family. (222 aa) |
| | HEL | Hevein-like preproprotein; Fungal growth inhibitors. Neither CB-HEL nor CD-HEL have chitinase activity, but both have antimicrobial activities. CD-HEL has RNase, but no DNase activity. (212 aa) |
| | DCL4 | Dicer-like protein 4; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Functions in the biogenesis of trans-acting small interfering RNAs (ta-siRNAs, derived from the TAS1, TAS2 or TAS3 endogenous transcripts) by cleaving small dsRNAs into 21- 24 nucleotide ta-siRNAs. Functions with the dsRNA-binding protein DRB4 in ta-siRNAs processing. Acts in the RDR6/SGS3/DCL4/AGO7 ta-siRNA pathway involved in leaf developmental timing. Plays a role in transitive silencing of transgenes by processing secondary siRNAs. This pathway, which requires DCL2 a [...] (1702 aa) |
| | NEN2 | Protein NEN2; Probable exonuclease involved in enuclation of sieve elements. (487 aa) |
| | CCR4-5 | Carbon catabolite repressor protein 4 homolog 5; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. (454 aa) |
| | RNL | tRNA ligase 1; Essential component of stress-response pathways entailing repair of RNA breaks with 2',3'-cyclic phosphate and 5'-OH ends. Tri-functional enzyme that repairs RNA breaks with 2',3'-cyclic-PO(4) and 5'-OH ends. The ligation activity requires three sequential enzymatic activities: opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester (CPDase activity), phosphorylation of the 5' terminus of the 3' half- tRNA in the presence of ATP (kinase activity) and ligation of the two tRNA halves in an ATP-dependent reaction (ligase activity). D [...] (1104 aa) |
| | Q2V3Q6_ARATH | tRNA-intron endonuclease. (118 aa) |
| | DCL2 | Endoribonuclease Dicer homolog 2; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Involved in the processing of natural small interfering RNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving small dsRNAs into 24 nucleotide nat- siRNAs. Plays an essential role in transitive silencing of transgenes by processing secondary siRNAs. This pathway, which requires DCL4 and RDR6, amplifies silencing by using the target RNA as substrate to generate secondary siRNAs, providing an efficient mechanism for long- distance silenci [...] (1388 aa) |
| | F24J8.21 | Zinc finger CCCH domain-containing protein 7; Possesses RNA-binding and ribonuclease activities in vitro. (470 aa) |
| | MORC6 | Protein MICRORCHIDIA 6; Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing. Together with SUVH2 and SUVH9, regulates the silencing of some transposable elements (TEs). Exhibits ATPase activity. May also be involved in the regulation of chromatin architecture/condensation to maintain gene silencing. Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity. Probably involved in DNA repair (By similarity). Positive regulator of defense against the oomycete Hyaloperonospora arabidopsidis (Hpa). Belongs to th [...] (663 aa) |
| | MORC2 | Protein MICRORCHIDIA 2; Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV). Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca(2+) accumulation. Required for pathogen-associated molecular pattern (PAMP)-triggered immunity, basal resistance, non-host resistance and systemic acquired resistance (SAR). Involved in RNA-directed DNA methylation (RdDM) as a component of the [...] (626 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meioti [...] (659 aa) |
| | T14C9.40 | Exosome complex exonuclease. (420 aa) |
| | FAN1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICLs). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity). May act upstream of the helicase RECQL4A and the ATPase RAD5A, which is involved in error-free post-replicative repair. Functions independently of MUS81 pathway, but in a similar pathway with RECQ4A, RAD5A and MFH1 in ICL repair. (891 aa) |
| | F16A14.30 | Restriction endonuclease, type II-like superfamily protein. (303 aa) |
| | PRORP1 | Proteinaceous RNase P 1, chloroplastic/mitochondrial; Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially cleaves at the unusual cleavage site, but also able to cleave at the classical cleavage site. Also involved in the maturation of mRNAs in mitochondria. (572 aa) |
| | F7P12.3 | 5'-3' exonuclease family protein. (347 aa) |
| | PRORP2 | Proteinaceous RNase P 2; Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Preferentially binds precursor tRNAs containing short 5' leaders and 3' trailers. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA) ; Belongs to the PPR family. P subfamily. (528 aa) |
| | CAF1-3 | Putative CCR4-associated factor 1 homolog 3; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (310 aa) |
| | RICE1 | Protein RISC-INTERACTING CLEARING 3'-5' EXORIBONUCLEASE 1; 3'-to-5' exoribonuclease (RNase) specifically targeting single-stranded RNAs. Triggers miRNA accumulation in RNA-induced silencing complex (RISC), composed of miRNAs and AGO proteins, by degrading uridylated cleavage fragments. Required during plant growth and development. Belongs to the RICE family. (200 aa) |
| | F13D4.60 | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity); Belongs to the RNase HII family. Eukaryotic subfamily. (296 aa) |
| | CAF1-6 | Probable CCR4-associated factor 1 homolog 6; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (274 aa) |
| | F25C20.3 | Endonuclease/exonuclease/phosphatase family protein. (441 aa) |
| | CAF1-2 | Probable CCR4-associated factor 1 homolog 2; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (286 aa) |
| | MYH9.5 | Putative endonuclease or glycosyl hydrolase. (924 aa) |
| | T9D9.16 | Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (368 aa) |
| | DPD1 | Exonuclease DPD1, chloroplastic/mitochondrial; Exonuclease required for organelle DNA degradation during pollen development. Plays non-essential roles in maternal inheritance. May be part of the DNA salvage machinery; Belongs to the exonuclease superfamily. TREX family. (316 aa) |
| | Q6DBN3_ARATH | tRNA-splicing endonuclease subunit. (254 aa) |
| | T29E15.4 | HNH endonuclease. (284 aa) |
| | Q6NQ97_ARATH | Putative endonuclease or glycosyl hydrolase. (489 aa) |
| | RNR1 | Ribonuclease II, chloroplastic/mitochondrial; 3'-5' exoribonuclease that catalyzes 3' maturation of chloroplast and mitochondrion ribosomal RNAs; degrades short nucleotidic extensions to generate the mature 3'-ends. Involved in the maturation of 23S, 16S and 5S rRNAs. (803 aa) |
| | T10C21.110 | Putative endonuclease or glycosyl hydrolase. (191 aa) |
| | WEX | Werner Syndrome-like exonuclease; Exonuclease that digests recessed strands of DNA duplexes in the 3' to 5' direction but hardly single-stranded DNA or blunt-ended duplexes. Also able to digest 3'-protruding strands and 3'-recessed strand termini of duplexes containing mismatched bases. (288 aa) |
| | EME1A | Crossover junction endonuclease EME1A; Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiot [...] (546 aa) |
| | Q84N39_ARATH | Endonuclease/glycosyl hydrolase. (106 aa) |
| | POLIB | DNA polymerase I B, chloroplastic/mitochondrial; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity (By similarity). Required for DNA replication and accumulation in plastids and mitochondria. (1034 aa) |
| | RNJ | Ribonuclease J; Essential protein required during embryogenesis, especially in initiating and maintaining the organization of shoot apical meristems (SAMs), cotyledons, and hypocotyls. Involved in auxin-mediated pathways during embryogenesis. RNase that has both endonuclease and 5'-3' exonuclease activities. Involved in RNA surveillance to prevent overaccumulation of antisense RNA. Probably involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity). Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-li [...] (911 aa) |
| | MORC1 | Protein MICRORCHIDIA 1; Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV). Exhibits ATPase activity. Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca(2+) accumulation. Required for pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), basal resistance, non-host resistance and systemic acquired resistance (SAR). Binds DNA/RNA in a non-specific manne [...] (635 aa) |
| | Q8GUH8_ARATH | Calcium-binding endonuclease/exonuclease/phosphatase family. (436 aa) |
| | CPSF73-II | Cleavage and polyadenylation specificity factor subunit 3-II; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. May function as mRNA 3'-end-processing endonuclease and also be involved in the histone 3'-end pre-mRNA processing. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS11 subfamily. (613 aa) |
| | F12A21.19 | Restriction endonuclease, type II-like superfamily protein. (355 aa) |
| | MOC1 | Holliday junction resolvase MOC1, chloroplastic; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Mediates chloroplast nucleoid segregation during chloroplast division. (273 aa) |
| | PNP1 | Polyribonucleotide nucleotidyltransferase 1, chloroplastic; Involved in the metabolism of all major classes of plastid RNAs. Required for efficient 3'-end processing of mRNAs and 3'-end maturation of rRNA transcripts, but is not sufficient to mediate their degradation. Mediates tRNA degradation. May function as a poly(A) mRNA 3'-5' degrading phosphorylase. May be required for plastid ribosome assembly and non-coding RNA biogenesis and accumulation. Seems not required for efficient translation. Belongs to the polyribonucleotide nucleotidyltransferase family. (922 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. (605 aa) |
| | F9F13.130 | Putative endonuclease or glycosyl hydrolase. (261 aa) |
| | YBEY | Endoribonuclease YBEY, chloroplastic; Endoribonuclease required for chloroplast ribosomal RNA (rRNA) processing and essential for normal growth and development. May be involved in maturation of both the 5' and 3' ends of 16S, 23S, and 4.5S rRNAs. Cleaves chloroplast rRNAs, mRNAs and tRNAs in vitro. Belongs to the endoribonuclease YbeY family. (584 aa) |
| | TRZ2 | tRNase Z TRZ2, chloroplastic; Zinc phosphodiesterase, which displays tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'- trailer from precursor tRNA. (354 aa) |
| | EXO1 | Exonuclease 1; Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity). Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. (735 aa) |
| | SDN5 | Small RNA degrading nuclease 5; Probable 3'-5' exonuclease degrading single-stranded small RNAs. (567 aa) |
| | F6E21.70 | Endonuclease V family protein. (277 aa) |
| | Q8LAA0_ARATH | Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (275 aa) |
| | NMAT2 | Nuclear intron maturase 2, mitochondrial; Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Involved in the splicing of mitochondrial COX2, NAD1 and NAD7 transcripts. Necessary for mitochondrial biogenesis during early developmental stages. (735 aa) |
| | RTL3 | Ribonuclease 3-like protein 3; Ribonuclease that cleaves double-stranded RNA (dsRNA). (957 aa) |
| | MUF9.2 | Exonuclease V, chloroplastic; Single-stranded DNA (ssDNA) bidirectional exonuclease. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends (By similarity). (413 aa) |
| | NOB1 | RNA-binding NOB1-like protein; Essential protein required during embryogenesis and pollen development. Endonuclease cleaving pre-rRNA at the 3' end of the mature 18S rRNA (D-site); cleaves 20S pre-rRNA in the cytoplasm. Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. (602 aa) |
| | NEN1 | Protein NEN1; Probable exonuclease involved in enuclation of sieve elements. (468 aa) |
| | TSN2 | Ribonuclease TUDOR 2; Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress. Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat). Involved in gibberellic acid (GA) biosynthesis and seed germination. Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway. Component of stress gr [...] (985 aa) |
| | CAF1-11 | Probable CCR4-associated factor 1 homolog 11; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (278 aa) |
| | RICE2 | Protein RISC-INTERACTING CLEARING 3'-5' EXORIBONUCLEASE 2; 3'-to-5' exoribonuclease (RNase) specifically targeting single-stranded RNAs. Triggers miRNA accumulation in RNA-induced silencing complex (RISC), composed of miRNAs and AGO proteins, by degrading uridylated cleavage fragments. Required during plant growth and development (By similarity). Belongs to the RICE family. (206 aa) |
| | ENDO3 | Endonuclease 3; Endonuclease that can use RNA and single-stranded DNA as substrates. In contradiction with cannot hydrolyze single-stranded DNA and does not cleave mismatches. (294 aa) |
| | TRZ1 | tRNase Z TRZ1; Zinc phosphodiesterase, which displays tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Can use bis-(p-nitophenyl) phosphate (bpNPP) as substrate. Involved in the processing of small nucleolar RNAs (snoRNAs). (280 aa) |
| | SDN3 | Small RNA degrading nuclease 3; 3'-5' exonuclease degrading single-stranded small RNAs. (782 aa) |
| | dl4845w-2 | Decapping nuclease DXO homolog, chloroplastic; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Belongs to the DXO/Dom3Z family. (544 aa) |
| | XRN2 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA-derived loops, excised during miRNA maturation in the nucleus. Involved in pre-rRNA processing. Involved in the primary exonucleolytic shortening of the 5' external transcribed spacer (5'ETS), required for endonucleolytic processing at site P by the U3 snoRNP complex. Involved with XRN3 in the 5'-end processing of 5.8S and 25S rRNAs. Contributes with XRN3 to polyadenylation-dependent nuclear RNA surveillance. Involved in the deg [...] (1012 aa) |
| | XRN3 | 5'-3' exoribonuclease 3; Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA-derived loops, excised during miRNA maturation in the nucleus. Required for proper development. Involved in pre-rRNA processing. Involved with XRN2 in the 5'-end exonucleolytic processing of 5.8S and 25S rRNAs. Contributes with XRN2 to polyadenylation-dependent nuclear RNA surveillance. Involved in the degradation of aberrant polyadenylated pre-rRNA through 5'-end processing. (1020 aa) |
| | XRN4 | 5'-3' exoribonuclease 4; Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA target cleavage products that lack a 5'-cap structure. Antagonizes the negative feedback regulation on EIN3 by promoting EBF1 and EBF2 mRNA decay, which consequently allows the accumulation of EIN3 protein to trigger the ethylene response. (947 aa) |
| | TRZ3 | tRNase Z TRZ3, mitochondrial; Zinc phosphodiesterase, which displays tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Can process the mitochondrial tRNA-like structures (t-elements). Involved in the processing of small nucleolar RNAs (snoRNAs). (890 aa) |
| | CCR4-6 | Carbon catabolite repressor protein 4 homolog 6; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. (754 aa) |
| | TSN1 | Ribonuclease TUDOR 1; Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress. Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat). Involved in gibberellic acid (GA) biosynthesis. Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway. Component of stress granules (SGs) that reg [...] (991 aa) |
| | CCR4-1 | Carbon catabolite repressor protein 4 homolog 1; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. (602 aa) |
| | BBD1 | Bifunctional nuclease 1; Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid- derived callose deposition following infection by a necrotrophic pathogen; Belongs to the bifunctional nuclease family. (325 aa) |
| | CAF1-10 | Probable CCR4-associated factor 1 homolog 10; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (277 aa) |
| | T27I15_190 | Putative endonuclease or glycosyl hydrolase. (166 aa) |
| | T27I15_180 | Putative endonuclease or glycosyl hydrolase. (180 aa) |
| | T27I15_30 | Putative endonuclease or glycosyl hydrolase. (257 aa) |
| | PARN | Poly(A)-specific ribonuclease PARN; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. Essential for early development, possibly by participating in silencing certain maternal mRNAs translationally. May have a pivotal role in stress response; Belongs to the CAF1 family. (689 aa) |
| | UVH1 | DNA repair endonuclease UVH1; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). Involved in repair of UV light, and probably oxidative damage. The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5' to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. May mediate the induction of a DNA-damage sensitive cell- cycle checkpoint during the G2 phase. (956 aa) |
| | GEN1 | Flap endonuclease GEN-like 1; Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA; Belongs to the XPG/RAD2 endonuclease family. GEN subfamily. (599 aa) |
| | CCR4-3 | Carbon catabolite repressor protein 4 homolog 3; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Belongs to the CCR4/nocturin family. (448 aa) |
| | RTL2 | Ribonuclease 3-like protein 2; Ribonuclease that cleaves double-stranded RNA (dsRNA). Required for 3'-external transcribed spacer (ETS) cleavage of the pre- rRNA precursors. May promote the production of 21 nucleotide small interfering RNA (siRNA) during post-transcriptional gene silencing (PTGS). (391 aa) |
| | EMB1789 | Zinc finger CCCH domain-containing protein 65; Possesses RNA-binding and ribonuclease activities in vitro. (675 aa) |
| | MWD22.11 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (285 aa) |
| | POLD1 | DNA polymerase delta catalytic subunit; This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. (1095 aa) |
| | RRP46 | Exosome complex exonuclease RRP46 homolog; Probable component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. (239 aa) |
| | CAF1-9 | Probable CCR4-associated factor 1 homolog 9; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (280 aa) |
| | CAF1-8 | Putative CCR4-associated factor 1 homolog 8; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (239 aa) |
| | DCL3 | Endoribonuclease Dicer homolog 3; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Involved in the processing of repeat-associated small interfering RNAs (ra-siRNAs, derived from heterochromatin and DNA repeats such as transposons) by cleaving small dsRNAs into 24 nucleotide ra-siRNAs. Plays a role in antiviral RNA silencing. Involved in the production of viral siRNAs derived from the cabbage leaf curl virus (CaLCuV) and tobacco rattle virus (TRV). Targeted by the viral silencing suppressor (VSR) protein 2b of the cucumber mosaic virus (CMV [...] (1580 aa) |
| | NMAT3 | Nuclear intron maturase 3, mitochondrial; Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Necessary for mitochondrial biogenesis during early developmental stages; Belongs to the plant nuclear intron maturase (nMat) family. (723 aa) |
| | T12C14_160 | Putative endonuclease or glycosyl hydrolase. (200 aa) |
| | F24I3.190 | Exonuclease V. (136 aa) |
| | T17J13.170 | Putative endonuclease or glycosyl hydrolase. (279 aa) |
| | MWL2.4 | Poly(A)-specific ribonuclease PARN-like; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs (By similarity); Belongs to the CAF1 family. (618 aa) |
| | F4B12.5 | Uncharacterized exonuclease domain-containing protein At3g15140. (337 aa) |
| | BBD2 | Bifunctional nuclease 2; Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid- derived callose deposition following infection by a necrotrophic pathogen (By similarity); Belongs to the bifunctional nuclease family. (329 aa) |
| | T10F20.10 | 5'-3' exonuclease family protein. (577 aa) |
| | F13M7.1 | Zinc finger CCCH domain-containing protein 3; Possesses RNA-binding and ribonuclease activities in vitro. (404 aa) |
| | RE1 | Retrovirus-related Pol polyprotein from transposon RE1. (1466 aa) |
| | ALP1 | Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1; Transposase-derived protein that may have nuclease activity (Probable). Antagonist of polycomb-group (PcG) protein-mediated chromatin silencing, probably by preventing the association of POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) with its accessory components. Needed for full reactivation of several floral homeotic genes that are repressed by PcG ; Belongs to the HARBI1 family. (396 aa) |
| | UVH3 | DNA repair protein UVH3; Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3'-incision step in NER. Seems to play a role in senescence program; Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. (1479 aa) |
| | CAF1-4 | Putative CCR4-associated factor 1 homolog 4; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (302 aa) |
| | NMAT1 | Nuclear intron maturase 1, mitochondrial; Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Necessary for mitochondrial biogenesis during early developmental stages. Involved in the splicing of mitochondrial NAD4 transcripts. Required for trans-splicing of NAD1 intron 1 and also functions in cis-splicing of NAD2 intron 1 and NAD4 intron 2. Required for the regulation of fundamental metabolic pathways such as amino acid metabolism, triacylglycerol degradation and polysaccharide synthesis (cellulose and starch) during the early stage of plant growth. Imp [...] (711 aa) |
| | CPSF73-I | Cleavage and polyadenylation specificity factor subunit 3-I; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. May function as mRNA 3'-end-processing endonuclease and also be involved in the histone 3'-end pre-mRNA processing. (693 aa) |
| | ENDO2 | Endonuclease 2; Endonuclease mostly active on RNA and ssDNA, and to a lower extent, on dsDNA. Can cleave mismatch regions in heteroduplex DNA containing single base pair mismatches or insertion/deletion bases. In contradiction with cannot hydrolyze single-stranded DNA and does not cleave mismatches. Belongs to the nuclease type I family. (290 aa) |
| | NEN3 | Protein NEN3; Probable exonuclease that may be involved in enuclation of sieve elements. (506 aa) |
| | NMAT4 | Nuclear intron maturase 4, mitochondrial; Nuclear-encoded maturase required for splicing of group-II introns in mitochondria. Involved in NAD1 pre-mRNA processing and maturation of introns 1, 3 and 4. Necessary for mitochondrial biogenesis during early developmental stages. Essential for respiratory holocomplex I biogenesis in mitochondria. (798 aa) |
| | SDN2 | Small RNA degrading nuclease 2; 3'-5' exonuclease degrading single-stranded small RNAs; Belongs to the REXO1/REXO3 family. (466 aa) |
| | MVP7.3 | Putative endonuclease or glycosyl hydrolase. (841 aa) |
| | T17J13.160 | Putative endonuclease or glycosyl hydrolase. (673 aa) |
| | CCR4-2 | Carbon catabolite repressor protein 4 homolog 2; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. (603 aa) |
| | PEL2 | Protein PELOTA 2; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily. (395 aa) |
| | T22E16.10 | Protein ALP1-like; Transposase-derived protein that may have nuclease activity. (406 aa) |
| | GEN2 | Flap endonuclease GEN-like 2; Belongs to the XPG/RAD2 endonuclease family. GEN subfamily. (600 aa) |
| | F6A14.21 | HNH endonuclease domain-containing protein. (186 aa) |
| | PNP2 | Polyribonucleotide nucleotidyltransferase 2, mitochondrial; Involved in the 3'-end maturation of mitochondrial mRNAs, rRNAs and tRNAs. Functions as a poly(A) mRNA 3'-5' degrading phosphorylase and is required for the degradation of highly expressed transcripts of non-coding regions; Belongs to the polyribonucleotide nucleotidyltransferase family. (991 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1; Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5' to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 [...] (410 aa) |
| | T20P8.2 | Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (222 aa) |
| | T25N22.7 | Exosome complex exonuclease RRP46-like protein. (150 aa) |
| | Q9ZU79_ARATH | Exonuclease family protein. (344 aa) |
| | RE2 | Retrovirus-related Pol polyprotein from transposon RE2. (1456 aa) |
| | PEL1 | Protein PELOTA 1; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). Belongs to the eukaryotic release factor 1 family. Pelota subfamily. (378 aa) |
| | MRE11 | Double-strand break repair protein MRE11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity); Belongs to the MRE11/RAD32 family. (720 aa) |
| | ENDO1 | Endonuclease 1; Endonuclease that can use RNA, single-stranded and double- stranded DNA as substrates. Hydrolyzes single- stranded DNA and RNA without apparent specificity for bases during senescence. Endonuclease that recognizes and cleaves all types of mismatches with high efficiency, including heteroduplex double-stranded DNA. Maybe involved in programmed cell death (PCD) and senescence. (305 aa) |
| | F4F15.60 | Zinc finger CCCH domain-containing protein 46; Possesses RNA-binding and ribonuclease activities in vitro. (540 aa) |
| | DCL1 | Endoribonuclease Dicer homolog 1; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta- siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of [...] (1909 aa) |
| | SDN4 | Putative small RNA degrading nuclease 4; Putative 3'-5' exonuclease degrading single-stranded small RNAs. (322 aa) |
| | CAF1-7 | Probable CCR4-associated factor 1 homolog 7; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (275 aa) |
| | F5G3.6 | Zinc finger CCCH domain-containing protein 18; Possesses ribonuclease activity in vitro. (536 aa) |
| | RRP44A | Exosome complex exonuclease RRP44 homolog A; Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Required for 5.8S rRNA intermediate processing and the degradation of 5' external transcribed spacer (5' ETS), a maturation by-product of rRNA synthesis. Is not involved in the degradation of turnip crinkle virus (TCV) RNA and significant virus resistance. Required for normal development of female gametophytes and early embryogenesis. (933 aa) |
| | CAF1-1 | Probable CCR4-associated factor 1 homolog 1; Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity). (360 aa) |
| | EME1B | Crossover junction endonuclease EME1B; Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiot [...] (551 aa) |
| | B3LFC1_ARATH | Exonuclease family protein. (357 aa) |
| | CPSF30 | 30-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] (631 aa) |
| | RRP6L2 | Protein RRP6-like 2; Acts as an important epigenetic regulator through multiple silencing mechanisms. Involved in association with RRP6L1 in the silencing of the solo LTR locus. Controls levels of non-coding RNAs (ncRNAs) from the solo LTR locus. Seems to function independently of the RNA-mediated gene silencing (RdDM) pathway. Functions redundantly with RRP6L1 in the regulation of FLC locus. Participates in the maintenance of trimethylated 'Lys-27' (H3K27me3) at FLC locus via the regulation of antisense long non-coding RNAs (lncRNAs) and the regulation of diverse antisense RNAs derive [...] (870 aa) |
| | CCR4-4 | Carbon catabolite repressor protein 4 homolog 4; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Transcriptional regulator of circadian rhythms with poly(A)-degrading activity that affects the expression and rhythmicity of the clock core oscillator genes TOC1 and CCA1. Deadenylation may be a mechanism involved in the regulation of the circadian clock. May play a negative role in response against oxidative stress. Possesses [...] (417 aa) |
| | A8MQG8_ARATH | 5'-3' exonuclease family protein. (448 aa) |
| | A6QR85_ARATH | Putative endonuclease or glycosyl hydrolase. (157 aa) |
| | SDN1 | Small RNA degrading nuclease 1; 3'-5' exonuclease degrading single-stranded small RNAs. Belongs to the REXO1/REXO3 family. (409 aa) |
| | K16H17.2 | 3'-5' exonuclease domain-containing protein. (516 aa) |
| | MAF19.19 | Putative endonuclease or glycosyl hydrolase with C2H2-type zinc finger domain-containing protein. (1057 aa) |
| | MPO12.2 | Exonuclease family protein. (357 aa) |
| | A0A1I9LRA7 | HNH endonuclease. (254 aa) |
