STRINGSTRING
PEX19-2 PEX19-2 PEX2 PEX2 PEX5 PEX5 PEX1 PEX1 PEX14 PEX14 PEX11A PEX11A PEX11C PEX11C PMD1 PMD1 FIS1A FIS1A PEX12 PEX12 PEX19-1 PEX19-1 PEX13 PEX13 PEX11B PEX11B PEX10 PEX10 PEX22 PEX22 PEX7 PEX7 PEX11D PEX11D PEX11E PEX11E ARC5 ARC5 PEX3-1 PEX3-1 DRP3B DRP3B PEX4-2 PEX4-2 PEX6 PEX6 PEX16 PEX16 DRP3A DRP3A PEX3-2 PEX3-2 FIS1B FIS1B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
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PEX19-2Peroxisome biogenesis protein 19-2; Contributes to morphology determination of peroxisomes, but not to import of peroxisomal matrix proteins. Required for proper post- translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer; Belongs to the peroxin-19 family. (245 aa)
PEX2Peroxisome biogenesis protein 2; Might act directly in a photomorphogenetic pathway negatively regulated by DET1, which is involved in peroxisome assembly and matrix protein import. Could be part of a complex responsible for the monoubiquitination of PEX5. Acts as an E3 ubiquitin-protein ligase. Belongs to the pex2/pex10/pex12 family. (333 aa)
PEX5Peroxisome biogenesis protein 5; Import receptor for peroxisomal-targeting signal one (PTS1). A receptor-cargo complex composed of PEX5, PEX7, a PTS1-containing protein and a PTS2-containing protein is targeted to peroxisomes during import. Necessary for the developmental elimination of obsolete peroxisome matrix proteins. (728 aa)
PEX1Peroxisome biogenesis protein 1; Involved in PTS1- and PTS2-dependent protein import into peroxisomes. May form heteromeric AAA ATPase complexes required for the import of proteins. (1130 aa)
PEX14Peroxisomal membrane protein PEX14; Controls intracellular transport of both PTS1- and PTS2- containing proteins. Required for the proper targeting of PEX7 to the peroxisome. (507 aa)
PEX11APeroxisomal membrane protein 11A; Involved in peroxisomal proliferation. Promotes peroxisomal duplication, aggregation or elongation without fission. (248 aa)
PEX11CPeroxisomal membrane protein 11C; Involved in peroxisomal proliferation. Promotes peroxisomal duplication, aggregation or elongation without fission. Belongs to the peroxin-11 family. (235 aa)
PMD1Peroxisomal and mitochondrial division factor 1; Involved in morphogenesis and proliferation of peroxisomes and mitochondria, independently from the previously defined pathway controlled by the FIS1-DRP3 complex. (318 aa)
FIS1AMitochondrial fission 1 protein A; Component of the peroxisomal and mitochondrial division machineries. Plays a role in promoting the fission of mitochondria and peroxisomes; Belongs to the FIS1 family. (170 aa)
PEX12Peroxisome biogenesis protein 12; Required for peroxisome biogenesis and for PTS1- and PTS2- dependent protein import into peroxisomes. Essential for the peroxisomal targeting of PEX7. Required for the export/release of receptors on the peroxisome membrane. Acts as an E3 ubiquitin-protein ligase involved in monoubiquitination of PEX5. (393 aa)
PEX19-1Peroxisome biogenesis protein 19-1; Contributes to morphology determination of peroxisomes, but not to import of peroxisomal matrix proteins. Required for proper post-translational import and stabilization of peroxisomal membrane proteins (PMPs). Acts as a cytosolic import receptor for PMPs and delivers them to the docking factor PEX3 at the peroxisomal membrane for subsequent insertion into the membrane. Required for transport of APEM9 to peroxisome membranes. Acts as a chaperone in stabilizing or maintaining PMPs in the lipid bilayer ; Belongs to the peroxin-19 family. (248 aa)
PEX13Peroxisomal membrane protein 13; Involved in PTS1- and PTS2-dependent protein import into peroxisomes. Required for PTS1- dependent protein import into pollen peroxisomes. Acts as a docking factor on peroxisomal membranes. Required for the proper targeting of PEX7 to the peroxisome. Required for the export/release of receptors on the peroxisome membrane. Essential for pollen-tube discharge that take place only in the presence of functional peroxisomes in either the male or the female gametophyte. Belongs to the peroxin-13 family. (304 aa)
PEX11BPeroxisomal membrane protein 11B; Involved in peroxisomal proliferation. Promotes peroxisomal duplication, aggregation or elongation without fission. (227 aa)
PEX10Peroxisome biogenesis factor 10; Involved in the formation of peroxisomes, lipid bodies and protein bodies. Required for normal-shaped peroxisomes that can physically associate with the outer membrane of the chloroplast envelope. Not involved in beta-oxidation and glyoxylate cycle. Acts as an E3 ubiquitin-protein ligase. Belongs to the pex2/pex10/pex12 family. (381 aa)
PEX22Peroxisome biogenesis protein 22; May be tethered PEX4 to the peroxisome membrane and may be involved in a late step of the matrix protein import. Does not play a role in the biogenesis of the peroxisomal membrane. (283 aa)
PEX7Peroxisome biogenesis protein 7; Import receptor for peroxisomal-targeting signal two (PTS2). A receptor-cargo complex composed of PEX5, PEX7, a PTS1-containing protein and a PTS2-containing protein is targeted to peroxisomes during import. Belongs to the WD repeat peroxin-7 family. (317 aa)
PEX11DPeroxisomal membrane protein 11D; Involved in peroxisomal proliferation. Promotes peroxisomal duplication, aggregation or elongation without fission. (236 aa)
PEX11EPeroxisomal membrane protein 11E; Involved in peroxisomal proliferation. Promotes peroxisomal duplication, aggregation or elongation without fission. Belongs to the peroxin-11 family. (231 aa)
ARC5Dynamin-like protein ARC5; Probable GTPase component of both plastid and peroxisme division machinery. Required for the last steps of plastid division specifically in mesophyll-cell, when the narrow isthmus breaks, facilitating the separation of the daughter plastids. Necessary for peroxisome activities. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (777 aa)
PEX3-1Peroxisome biogenesis protein 3-1; Involved in morphology determination of peroxisomes, but not in import of peroxisomal matrix proteins. May act as a docking factor for PEX19 and be necessary for the import of peroxisomal membrane proteins in the peroxisomes. (358 aa)
DRP3BDynamin-related protein 3B; Involved in the control of mitochondrial and peroxisomal division and morphology. (780 aa)
PEX4-2Protein PEROXIN-4; Required for peroxisome biogenesis. Necessary for the developmental elimination of obsolete peroxisome matrix proteins. May be involved in the ubiquitination of PEX5, targeting it for recycling. Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. (157 aa)
PEX6Peroxisome biogenesis protein 6; Involved in peroxisomal-targeting signal one (PTS1) and peroxisomal-targeting signal two (PTS2) protein import. Required for jasmonate biosynthesis. Necessary for the developmental elimination of obsolete peroxisome matix proteins. May form heteromeric AAA ATPase complexes required for the import of proteins. May be involved in PEX5 recycling. (941 aa)
PEX16Peroxisome biogenesis protein 16; Involved in the formation of peroxisomes, lipid bodies and protein bodies. (367 aa)
DRP3ADynamin-related protein 3A; Involved in the control of mitochondrial and peroxisomal division and morphology. In association with PEX11C, PEX11D, PEX11E and FIS1B, is involved in cell cycle-associated constitutive self- replication of preexisting peroxisomes. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (808 aa)
PEX3-2Peroxisome biogenesis protein 3-2; Involved in morphology determination of peroxisomes, but not in import of peroxisomal matrix proteins. May act as a docking factor for PEX19 and be necessary for the import of peroxisomal membrane proteins in the peroxisomes. (364 aa)
FIS1BMitochondrial fission 1 protein B; Component of the peroxisomal and mitochondrial division machineries. Plays a role in promoting the fission of mitochondria and peroxisomes. In association with PEX11C, PEX11D, PEX11E and DRP3A, is involved in cell cycle-associated constitutive self-replication of preexisting peroxisomes. (167 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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