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KIB1 | F-box/kelch-repeat protein KIB1; Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation. (382 aa) | ||||
KIB2 | F-box protein KIB2; Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation. (442 aa) | ||||
KIB4 | F-box protein KIB4; Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation. (393 aa) | ||||
IBH1 | Transcription factor IBH1; Atypical and probable non DNA-binding bHLH transcription factor that acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling. Is able to form heterodimer with BHLH49, thus inhibiting DNA binding of BHLH49, which is a transcriptional activator that regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds and inhibits HBI1, a positive regulator of cell elongation that directly binds to the promoters and activated [...] (156 aa) | ||||
WRKY46 | Probable WRKY transcription factor 46; Transcription factor involved in the regulation of osmotic stress responses and stomatal movement. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Positive regulator of EDS1-dependent defense against E.amylovora. Together with WRKY70 and WRKY53, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2. Together with WRKY54 and WRKY70, prom [...] (295 aa) | ||||
PAR1 | Transcription factor PAR1; Atypical bHLH transcription factor that acts as negative regulator of a variety of shade avoidance syndrome (SAS) responses, including seedling elongation and photosynthetic pigment accumulation. Acts as direct transcriptional repressor of two auxin-responsive genes, SAUR15 and SAUR68. May function in integrating shade and hormone transcriptional networks in response to light and auxin changes. (118 aa) | ||||
MYB56 | Transcription factor MYB56; Acts as a cell-specific local repressor of quiescent center (QC) self-renewal by cell divisions in the primary root. Counteracts brassinosteroid (BR)-mediated cell division in the QC cells. Regulates maternally seed size, especially before the heart stage, promoting both endothelial cells expansion and cell number in the outer integument layer of the seed coat. Modulates the expression of genes involved in cell wall metabolism such as cell division and expansion. Negative regulator of flowering via the repression of FT transcription. (323 aa) | ||||
B'THETA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Associates with the serine/threonine-protein phosphatase PP2A catalytic subunit C and regulatory subunit A to positively regulates beta-oxidation of fatty acids and protoauxins in peroxisomes by dephosphorylating peroxisomal beta-oxidation-related proteins. Required for the formation of the PP2A holoenzym [...] (492 aa) | ||||
B'GAMMA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signaling by dephosphorylating and inactivating BRI1 in the cytoplasm. Seems to be functionally connected with CPR5 and may mediate the negative regulation of defense reactions and senescence under low irradiances. [...] (522 aa) | ||||
BZR1 | Protein BRASSINAZOLE-RESISTANT 1; Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5'-CGTG(T/C)G-3' in gene promoter. Regulates positively the brassinosteroid-signaling pathway. Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis. Promotes growth. Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e.g. HLL, ANT, and AP2). (336 aa) | ||||
BPG2 | GTP-binding protein BRASSINAZOLE INSENSITIVE PALE GREEN 2, chloroplastic; Required for brassinosteroid- (BR) mediated post- transcriptional and translational regulation in the chloroplast, including accumulation of chloroplast rRNA. Involved in chloroplast differentiation. (660 aa) | ||||
BSK3 | Serine/threonine-protein kinase BSK3; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Mediates signal transduction from BRI1 by functioning as substrate of BRI1. Functions redundantly with BSK4, BSK6, BSK7 and BSK8. (489 aa) | ||||
WRKY54 | Probable WRKY transcription factor 54; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Together with WRKY70, negative regulator of developmental senescence, probably via the regulation of several senescence-associated markers genes. Positive regulator of EDS1-dependent defense against E.amylovora. In collaboration with WRKY70, prevents stomatal closure and, consequently, osmotic stress tolerance. Together with WRKY46 and WRKY70, promotes brassinosteroid (BR)- regulated plant [...] (346 aa) | ||||
BSK1 | Serine/threonine-protein kinase BSK1; Serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Mediates signal transduction from BRI1 by functioning as substrate of BRI1. Functions as a positive regulator of plant immunity. May be involved in the regulation of pattern-triggered immunity (PTI) downstream of the flagellin receptor FLS2. Possesses kinase activity in vitro. Kinase activity is required for its function in innate immunity. (512 aa) | ||||
PRE3 | Transcription factor PRE3; Atypical and probable non DNA-binding bHLH transcription factor required for MONOPTEROS-dependent root initiation in embryo. Promotes the correct definition of the hypophysis cell division plane. Transcriptionally controlled by MONOPTEROS. Moves from its site of synthesis in pro-embryos cells into the hypophysis. Regulates brassinosteroid (BR) signaling by sequestering negative BR signaling components. May function as positive regulator of gibberellin signaling. May play a role in the regulation of light signaling and possibly auxin signaling. (93 aa) | ||||
BSK8 | Serine/threonine-protein kinase BSK8; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Functions redundantly with BSK3, BSK4, BSK6 and BSK7. Involved in the regulation of sucrose-phosphate synthase 1 (SPS1) in the context of sucrose resuply after starvation. Activates BSL2, a phosphatase that may dephosphorylate SPS1, leading to the activation of SPS1 ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (487 aa) | ||||
BSK5 | Serine/threonine-protein kinase BSK5; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Involved in abiotic stress tolerance. Required for salt stress and abscisic acid-mediated drought stress tolerance. (489 aa) | ||||
PRE1 | Transcription factor PRE1; Atypical and probable non DNA-binding bHLH transcription factor that integrates multiple signaling pathways to regulate cell elongation and plant development. Binds IBH1, forming a pair of antagonistic bHLH transcription factors that function downstream of BZR1 to mediate brassinosteroid regulation of cell elongation. Regulates light responses by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance. May have a regulatory role in various aspects of gibberellin-dependent growth an [...] (92 aa) | ||||
BKI1 | BRI1 kinase inhibitor 1; Negative regulator of brassinosteroid signaling. When associated to the membrane, limits the interaction of BRI1 with BAK1 by binding to the kinase-inactive form of BRI1. (337 aa) | ||||
TOR | Serine/threonine-protein kinase TOR; Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival. Involved in modulating the transition from heterotrophic [...] (2481 aa) | ||||
BZR2 | Protein BRASSINAZOLE-RESISTANT 2; Positive regulator of brassinosteroid (BR) signaling. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5'-CANNTG-3'(E box) through its N- terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C- terminal domain is probably involved in transcriptional activation. Recruits the transcription elongation factor IWS1 to control BR- regulated gene expression. Forms a trimeric complex with IWS1 and ASHH2/SDG8 to regulate BR-reg [...] (335 aa) | ||||
BSK2 | Serine/threonine-protein kinase BSK2; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Mediates signal transduction from BRI1 by functioning as substrate of BRI1. (489 aa) | ||||
CDG1 | Serine/threonine-protein kinase CDG1; Serine/threonine-protein kinase involved in the positive regulation of brassinosteroid (BR) signaling and plant growth. Mediates BR signal transduction from BRI1 receptor kinase to BSU1 phosphatase. After activation by phosphorylation at Ser-234 by BRI1, CDG1 phosphorylates BSU1 at 'Ser-764' in the phosphatase domain, increasing the ability of BSU1 to inactivate the negative regulator of BR signaling ASK7/BIN2 by dephosphorylation at 'Tyr-200'. The full kinase activity of CDG1 is required for its biological function. (432 aa) | ||||
B'ETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). The holoenzyme composed of PP2AA1, PP2A4 and B'ETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes. Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signalin [...] (510 aa) | ||||
RALF23 | Rapid alkalinization factor 23; Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity). Regulates negatively brassinolide (BL)-mediated signaling pathway (e.g. BL-induced hypocotyl elongation and branching limitation). (138 aa) | ||||
B'ZETA | Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). The holoenzyme composed of PP2AA1, PP2A4 and B'ZETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes. Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signal [...] (546 aa) | ||||
PAR2 | Transcription factor PAR2; Atypical bHLH transcription factor that acts as negative regulator of a variety of shade avoidance syndrome (SAS) responses, including seedling elongation and photosynthetic pigment accumulation. Acts as direct transcriptional repressor of two auxin-responsive genes, SAUR15 and SAUR68. May function in integrating shade and hormone transcriptional networks in response to light and auxin changes. (118 aa) | ||||
WRKY70 | Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa) | ||||
IBL1 | Transcription factor IBH1-like 1; Functions redundandly with IBH1/BHLH158 in a regulation node known as the incoherent feed-forward loop (FFL). Acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling. (180 aa) | ||||
LFG2 | Protein LIFEGUARD 2; Regulates the brassinosteroid (BR) signaling pathway that mediates cell elongation and organ morphogenesis. (Microbial infection) May prevent cell death upon A.alternata f.sp. lycopersici (AAL) toxin treatment. (239 aa) | ||||
BSK6 | Serine/threonine-protein kinase BSK6; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Functions redundantly with BSK3, BSK4, BSK7 and BSK8. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (490 aa) | ||||
FER | Receptor-like protein kinase FERONIA; Receptor-like protein kinase that mediates the female control of male gamete delivery during fertilization, including growth cessation of compatible pollen tubes ensuring a reproductive isolation barriers, by regulating MLO7 subcellular polarization upon pollen tube perception in the female gametophyte synergids. Required for cell elongation during vegetative growth, mostly in a brassinosteroids- (BR-) independent manner. Acts as an upstream regulator for the Rac/Rop-signaling pathway that controls ROS-mediated root hair development. Seems to regul [...] (895 aa) | ||||
KIB3 | F-box protein KIB3; Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation. (450 aa) | ||||
HBI1 | Transcription factor HBI1; Atypical bHLH transcription factor that acts as positive regulator of cell elongation downstream of multiple external and endogenous signals by direct binding to the promoters and activation of the two expansin genes EXPA1 and EXPA8, encoding cell wall loosening enzymes. Transcriptional activity is inhibited when binding to the bHLH transcription factor IBH1. (337 aa) | ||||
BRH1 | Brassinosteroid-responsive RING protein 1; May be involved in the brassinosteroids (BRs) signaling pathway and regulate the growth and development of rosette leaves. Seems to prevent over development of leaves and inflorescence stems. (170 aa) | ||||
BIA1 | BAHD acyltransferase BIA1; Monitors brassinosteroids (BR) responses and homeostasis, particularly in the root and hypocotyl in darkness. Promotes flavonoid biosynthesis. Belongs to the plant acyltransferase family. (435 aa) | ||||
PBL7 | Probable serine/threonine-protein kinase PBL7; Serine/threonine-protein kinase involved in the positive regulation of brassinosteroid (BR) signaling and plant growth. Phosphorylates both BSU1 and BSL1 in vitro. (378 aa) | ||||
ASK7 | Shaggy-related protein kinase eta; Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5. Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 AND BSK11 in v [...] (380 aa) | ||||
MAKR1 | Probable membrane-associated kinase regulator 1; May negatively regulate brassinosteroid signaling. (341 aa) | ||||
BSK12 | Probable inactive receptor-like kinase BSK12; Probable inactive protein kinase that activates the YODA MAP kinase cascade, which regulates the asymmetric first division and embryo polarity, by promoting the elongation of the zygote and the development of its basal daughter cell into the extra-embryonic suspensor. Acts as an adapter at the plasma membrane, possibly by recruiting and binding an activator. (465 aa) | ||||
BSK4 | Serine/threonine-protein kinase BSK4; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Functions redundantly with BSK3, BSK6, BSK7 and BSK8. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (483 aa) | ||||
BSK7 | Serine/threonine-protein kinase BSK7; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Functions redundantly with BSK3, BSK5, BSK6 and BSK8. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (487 aa) | ||||
IWS1 | Protein IWS1 homolog 1; Transcription factor involved in RNA polymerase II (RNAPII) transcription regulation. Involved in transcription elongation. May function at post-recruitment and elongation steps of transcription. May be recruited by BZR2/BES1 to target genes and promote their expression during transcription elongation process. Required for brassinosteroid (BR)-induced gene expression. Required the for regulation of numerous nitrogen-responsive genes in roots. Acts in roots to repress NRT2.1 transcription in response to high nitrogen supply. This repression is associated with an [...] (502 aa) | ||||
B'ALPHA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Required for the formation of the PP2A holoenzyme that positively regulates brassinosteroid signaling by dephosphorylating and activating BZR1. (495 aa) | ||||
B'BETA | Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Required for the formation of the PP2A holoenzyme that positively regulates brassinosteroid signaling by dephosphorylating and activating BZR1. (499 aa) | ||||
GCR1 | G-protein coupled receptor 1; Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate(IP(3)) as a second messenger. Acts as a negative regulator of GPA1-mediated abscisic acid (ABA) responses in guard cells, and together with GPA1 and GB1 during seed germination and early seedling development. Promotes PI-PLC activity and IP(3) accumulation. Involved in the blue light (BL) signaling. Together with GPA1 and ADT3, required for BL- mediated synthesis of phenylpy [...] (326 aa) | ||||
BRI1 | Protein BRASSINOSTEROID INSENSITIVE 1; Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Pho [...] (1196 aa) |