STRINGSTRING
A0A1I9LLN7 A0A1I9LLN7 A0A1I9LQI3 A0A1I9LQI3 A0A1I9LT28 A0A1I9LT28 AT1G24570.2 AT1G24570.2 A0A1P8ARQ6 A0A1P8ARQ6 A0A1P8B1J7 A0A1P8B1J7 A0A1P8B3C0 A0A1P8B3C0 A0A1P8BD70 A0A1P8BD70 RALFL29 RALFL29 POT1C POT1C NAC014 NAC014 ATRX ATRX F4HWA5_ARATH F4HWA5_ARATH F4HXC5_ARATH F4HXC5_ARATH F10B6.21 F10B6.21 F28J9.5 F28J9.5 CTF18 CTF18 F4IHC4_ARATH F4IHC4_ARATH F16B22.7 F16B22.7 F4J9R7_ARATH F4J9R7_ARATH F4JA83_ARATH F4JA83_ARATH NTL9 NTL9 RPA1E RPA1E F4JTU8_ARATH F4JTU8_ARATH CBP60G CBP60G T32B20.70 T32B20.70 F17P19.12 F17P19.12 T14G11.23 T14G11.23 H2B H2B ANAC023 ANAC023 T13D8.18 T13D8.18 T13D8.21 T13D8.21 NAC024 NAC024 T13D8.25 T13D8.25 T6B13.1 T6B13.1 HTB4 HTB4 Q058G7_ARATH Q058G7_ARATH F18O22.250 F18O22.250 RECQL5 RECQL5 POLD4 POLD4 T4C15.5 T4C15.5 Q45GK3_ARATH Q45GK3_ARATH T1B3.17 T1B3.17 POT1B POT1B WEX WEX F13F21.30 F13F21.30 NAC074 NAC074 Q8GUM8_ARATH Q8GUM8_ARATH RECQL4A RECQL4A AT1G13000.1 AT1G13000.1 F20H23.3 F20H23.3 NOP10 NOP10 AT1G08040.1 AT1G08040.1 AT1G67850.1 AT1G67850.1 NAC089 NAC089 F28L5.11 F28L5.11 T2E22.25 T2E22.25 T22A15.5 T22A15.5 F14G24.22 F14G24.22 HTB2 HTB2 RPA1C RPA1C TBL4 TBL4 K9I9.20 K9I9.20 MRG7.14 MRG7.14 RPA1D RPA1D RECQSIM RECQSIM RECQL4B RECQL4B RECQL3 RECQL3 F3G5.26 F3G5.26 RECQL1 RECQL1 F12K22.16 F12K22.16 T14P4.13 T14P4.13 F12A21.25 F12A21.25 CBF5 CBF5 T22D6.120 T22D6.120 F4P12.350 F4P12.350 Q9LH38_ARATH Q9LH38_ARATH T2E22.21 T2E22.21 T2E22.22 T2E22.22 T2E22.24 T2E22.24 T2E22.27 T2E22.27 K23F3.7 K23F3.7 HTB1 HTB1 MGL6.4 MGL6.4 T22P11.160 T22P11.160 T12C14_20 T12C14_20 HTB11 HTB11 T16K5.180 T16K5.180 NAC049 NAC049 NAC062 NAC062 T18N14.80 T18N14.80 RPA1B RPA1B F11F8.5 F11F8.5 T23G18.3 T23G18.3 T11P11.3 T11P11.3 F9C22.4 F9C22.4 RPA1A RPA1A TERT TERT NTL8 NTL8
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
A0A1I9LLN7Transmembrane protein, putative (DUF707). (419 aa)
A0A1I9LQI3Replication protein A1. (177 aa)
A0A1I9LT28Uncharacterized protein. (248 aa)
AT1G24570.2Transmembrane protein, putative (DUF707). (388 aa)
A0A1P8ARQ6Uncharacterized protein. (1041 aa)
A0A1P8B1J7Transmembrane protein. (227 aa)
A0A1P8B3C0Replication-like protein. (139 aa)
A0A1P8BD70Nucleic acid-binding, OB-fold-like protein. (192 aa)
RALFL29Protein RALF-like 29; Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity). (90 aa)
POT1CProtection of telomeres protein 1c; Binds specifically single-stranded telomeric DNA with weak affinity. Has probably no function in the regulation of telomere length. (144 aa)
NAC014NAC domain-containing protein 14; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). (652 aa)
ATRXProtein CHROMATIN REMODELING 20; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes (By similarity). Involved in DNA repair of gamma-irradiation-mediated damages. (1479 aa)
F4HWA5_ARATHE3 ubiquitin ligase. (170 aa)
F4HXC5_ARATHF-box protein. (243 aa)
F10B6.21Nucleic acid-binding, OB-fold-like protein. (384 aa)
F28J9.5Nucleic acid-binding proteins superfamily. (351 aa)
CTF18P-loop containing nucleoside triphosphate hydrolases superfamily protein. (943 aa)
F4IHC4_ARATHNucleic acid-binding, OB-fold-like protein. (532 aa)
F16B22.7Zinc ion binding protein. (386 aa)
F4J9R7_ARATHPolynucleotidyl transferase, ribonuclease H-like superfamily protein. (185 aa)
F4JA83_ARATHNucleic acid-binding proteins superfamily. (309 aa)
NTL9Protein NTM1-like 9; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Calmodulin-regulated transcriptional repressor. Binds several synthetic promoters with randomly selected binding sites. Functions synergistically with SNI1 as negative regulator of pathogen-induced PR1 expression and basal resistance to a virulent strain of P.syringae. Binds directly to the promoter of the PR1 gene. Acts as positive regulator of innate immunity. Involved in the effector-triggered immunity (ETI) induction of immunity-related gene expression [...] (512 aa)
RPA1EReplication protein A 70 kDa DNA-binding subunit E; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (784 aa)
F4JTU8_ARATHPolynucleotidyl transferase, ribonuclease H-like superfamily protein. (263 aa)
CBP60GCalmodulin-binding protein 60 G; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1, PR2 and EDS5) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326, P. syringae pv. tomato DC3000, and microbe- associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e.g. UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis. Involved in b [...] (563 aa)
T32B20.70ATP-dependent DNA helicase; Belongs to the helicase family. (337 aa)
F17P19.12Chromosome transmission fidelity-like protein. (145 aa)
T14G11.23Uncharacterized protein At2g34110. (123 aa)
H2BHistone H2B.6; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (150 aa)
ANAC023NAC domain containing protein 23. (347 aa)
T13D8.18NAC (No Apical Meristem) domain transcriptional regulator superfamily protein. (322 aa)
T13D8.21NAC (No Apical Meristem) domain transcriptional regulator superfamily protein. (371 aa)
NAC024NAC domain containing protein 24. (320 aa)
T13D8.25NAC (No Apical Meristem) domain transcriptional regulator superfamily protein. (318 aa)
T6B13.1F-box protein At2g14710. (362 aa)
HTB4Histone H2B.11; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (150 aa)
Q058G7_ARATHF-box family protein. (114 aa)
F18O22.250Pseudouridine synthase family protein. (540 aa)
RECQL5ATP-dependent DNA helicase Q-like 5; 3'-5' DNA helicase that may play a role in the repair of DNA. (911 aa)
POLD4Polymerase delta 4. (124 aa)
T4C15.5F-box protein At2g35280. (163 aa)
Q45GK3_ARATHATP-dependent DNA helicase; Belongs to the helicase family. (331 aa)
T1B3.17Trimethylguanosine synthase (DUF707). (374 aa)
POT1BProtection of telomeres protein 1b; Negatively regulates telomerase activity and participates in chromosome end protection. Binds RNA non-specifically. Associates with a regulatory Pol III-dependent lncRNA, which represses telomerase activity in response to DNA damage. Binds single-stranded telomeric DNA with weak affinity. Belongs to the telombin family. (454 aa)
WEXWerner Syndrome-like exonuclease; Exonuclease that digests recessed strands of DNA duplexes in the 3' to 5' direction but hardly single-stranded DNA or blunt-ended duplexes. Also able to digest 3'-protruding strands and 3'-recessed strand termini of duplexes containing mismatched bases. (288 aa)
F13F21.30Transmembrane protein. (82 aa)
NAC074NAC domain containing protein 74. (352 aa)
Q8GUM8_ARATHMetal-dependent phosphohydrolase. (222 aa)
RECQL4AATP-dependent DNA helicase Q-like 4A; 3'-5' DNA helicase involved in DNA repair. Required for the maintenance of genome stability by modulation of the DNA damage response and repression of crossovers. Confers resistance to genotoxic stress. Suppresses spontaneous homologous recombination (HR) events in somatic cells together with its partners RMI1 and TOP3A. Contributes to the maintenance of chromosome integrity during meiosis. Involved in the removal of telomeric bridges that appear to arise during meiotic recombination. Required to resolve or dissolve MSH4-dependent telomeric associa [...] (1188 aa)
AT1G13000.1Transmembrane protein, putative (DUF707). (401 aa)
F20H23.3Putative H/ACA ribonucleoprotein complex subunit 1-like protein 1; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (202 aa)
NOP10H/ACA ribonucleoprotein complex subunit 3-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the NOP10 family. (64 aa)
AT1G08040.1Trimethylguanosine synthase (DUF707). (382 aa)
AT1G67850.1Lysine ketoglutarate reductase trans-splicing protein (DUF707). (404 aa)
NAC089NAC domain-containing protein 89; Transcription factor involved in plant cell division. (340 aa)
F28L5.11Transposon protein, putative. (1148 aa)
T2E22.25Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (238 aa)
T22A15.5F-box family protein. (80 aa)
F14G24.22Nucleic acid-binding, OB-fold-like protein. (566 aa)
HTB2Histone H2B.10; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)
RPA1CReplication protein A 70 kDa DNA-binding subunit C; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (853 aa)
TBL4Protein trichome birefringence-like 4; May act as a bridging protein that binds pectin and other cell wall polysaccharides. Probably involved in maintaining esterification of pectins (By similarity). May be involved in the specific O-acetylation of cell wall polymers (By similarity). (457 aa)
K9I9.20RuvB-like helicase; Belongs to the RuvB family. (469 aa)
MRG7.14H/ACA ribonucleoprotein complex subunit 1-like protein 2; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (189 aa)
RPA1DReplication protein A 70 kDa DNA-binding subunit D; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (629 aa)
RECQSIMATP-dependent DNA helicase Q-like SIM; Plant specific 3'-5' DNA helicase that may play a role in the repair of DNA. (858 aa)
RECQL4BATP-dependent DNA helicase Q-like 4B; 3'-5' DNA helicase that may play a role in the repair of DNA (By similarity). Required to promote but not to suppress crossovers. (1150 aa)
RECQL3ATP-dependent DNA helicase Q-like 3; 3'-5' DNA helicase that may play a role in the repair of DNA. Exhibits an ATP or dATP-dependent DNA-helicase activity. Can not use GTP/dGTP, CTP/dCTP or UTP/dUTP as nucleotide cofactors. Catalyzes DNA strand annealing. On nicked Holliday junctions, unwinds the lagging strand. Cannot act on intact Holliday junctions. Belongs to the helicase family. RecQ subfamily. (713 aa)
F3G5.26Histone H2B.4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (138 aa)
RECQL1ATP-dependent DNA helicase Q-like 1; 3'-5' DNA helicase that may play a role in the repair of DNA. Belongs to the helicase family. RecQ subfamily. (606 aa)
F12K22.16F-box/kelch-repeat protein At1g57790. (352 aa)
T14P4.13T14P4.13 protein. (290 aa)
F12A21.25Putative F-box protein At1g67623. (296 aa)
CBF5H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family. (565 aa)
T22D6.120H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity). (156 aa)
F4P12.350Histone H2B.8; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (138 aa)
Q9LH38_ARATHUncharacterized protein. (161 aa)
T2E22.21Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (220 aa)
T2E22.22Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (242 aa)
T2E22.24Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (353 aa)
T2E22.27Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (230 aa)
K23F3.7Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (199 aa)
HTB1Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (148 aa)
MGL6.4F-box/kelch-repeat protein At3g16580. (382 aa)
T22P11.160Histone H2B.9; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (132 aa)
T12C14_20Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (171 aa)
HTB11Histone H2B.7; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)
T16K5.180RuvB-like helicase; Belongs to the RuvB family. (473 aa)
NAC049NAC domain containing protein 49. (198 aa)
NAC062NAC domain-containing protein 62; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant resistance to pathogen infection, incorporating cold signals into pathogen resistance responses. Plays a regulatory role in abscisic acid (ABA)-mediated drought-resistance response. (469 aa)
T18N14.80ATP-dependent DNA helicase; Belongs to the helicase family. (344 aa)
RPA1BReplication protein A 70 kDa DNA-binding subunit B; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity). Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (604 aa)
F11F8.5Histone H2B.5; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
T23G18.3Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (243 aa)
T11P11.3Histone H2B.3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (151 aa)
F9C22.4Polynucleotidyl transferase, ribonuclease H-like superfamily protein. (239 aa)
RPA1AReplication protein A 70 kDa DNA-binding subunit A; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Plays an essential role at later stages of meiotic recombination events required for the formation of class I crossovers. Is essential for normal progression through meiosis in pollen mother cells. Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses, but does not seem to be required for the repair of meiot [...] (640 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Required to prevent genome instability induced by breakage-fusion-bridge (BFB) cycles. Can extend completely non-telomeric sequences using RNA template in vitro. (1123 aa)
NTL8NAC domain-containing protein 40; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP), probably via metalloprotease activity. Regulates gibberellic acid-mediated salt- responsive repression of seed germination and flowering via FT, thus delaying seed germination under high salinity conditions. (335 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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