STRINGSTRING
NAC049 NAC049 PCNA2 PCNA2 NTL8 NTL8 RPA1A RPA1A RPA1B RPA1B NAC062 NAC062 PCNA PCNA Q9LH38_ARATH Q9LH38_ARATH F12A21.25 F12A21.25 T14P4.13 T14P4.13 RPA1D RPA1D RPA1C RPA1C RFC5 RFC5 T5M16.21 T5M16.21 RFC2 RFC2 F14G24.22 F14G24.22 T22A15.5 T22A15.5 RFC1 RFC1 REV7 REV7 NAC089 NAC089 RFC4 RFC4 RFC3 RFC3 NAC074 NAC074 REV3 REV3 POLK POLK T4C15.5 T4C15.5 Q058G7_ARATH Q058G7_ARATH RPS27AA RPS27AA RPS27AC RPS27AC RPS27AB RPS27AB T13D8.25 T13D8.25 NAC024 NAC024 T13D8.21 T13D8.21 T13D8.18 T13D8.18 ANAC023 ANAC023 STI STI MRA19.13 MRA19.13 RPA1E RPA1E F22K18.10 F22K18.10 F28A21.230 F28A21.230 NTL9 NTL9 F4JA83_ARATH F4JA83_ARATH F4IHC4_ARATH F4IHC4_ARATH MEE13 MEE13 F28J9.5 F28J9.5 F4HXC5_ARATH F4HXC5_ARATH F4HWA5_ARATH F4HWA5_ARATH F14L17.24 F14L17.24 NAC014 NAC014 REV1 REV1 A0A1P8BD70 A0A1P8BD70 A0A1P8B3C0 A0A1P8B3C0 A0A1P8ARQ6 A0A1P8ARQ6 A0A1I9LT28 A0A1I9LT28 A0A1I9LQI3 A0A1I9LQI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NAC049NAC domain containing protein 49. (198 aa)
PCNA2Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity). May be involved in UV resistance. Belongs to the PCNA family. (264 aa)
NTL8NAC domain-containing protein 40; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP), probably via metalloprotease activity. Regulates gibberellic acid-mediated salt- responsive repression of seed germination and flowering via FT, thus delaying seed germination under high salinity conditions. (335 aa)
RPA1AReplication protein A 70 kDa DNA-binding subunit A; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Plays an essential role at later stages of meiotic recombination events required for the formation of class I crossovers. Is essential for normal progression through meiosis in pollen mother cells. Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses, but does not seem to be required for the repair of meiot [...] (640 aa)
RPA1BReplication protein A 70 kDa DNA-binding subunit B; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity). Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (604 aa)
NAC062NAC domain-containing protein 62; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant resistance to pathogen infection, incorporating cold signals into pathogen resistance responses. Plays a regulatory role in abscisic acid (ABA)-mediated drought-resistance response. (469 aa)
PCNAProliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
Q9LH38_ARATHUncharacterized protein. (161 aa)
F12A21.25Putative F-box protein At1g67623. (296 aa)
T14P4.13T14P4.13 protein. (290 aa)
RPA1DReplication protein A 70 kDa DNA-binding subunit D; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (629 aa)
RPA1CReplication protein A 70 kDa DNA-binding subunit C; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (853 aa)
RFC5Replication factor C subunit 5; Functions in cell replication and proliferation. May be involved in chromatin assembly and remodeling. Plays a role in the negative control of pathogenesis-related gene expression and systemic acquired resistance (SAR). (369 aa)
T5M16.21P-loop containing nucleoside triphosphate hydrolases superfamily protein. (1151 aa)
RFC2Replication factor C subunit 2; May be involved in DNA replication and thus regulate cell proliferation. (333 aa)
F14G24.22Nucleic acid-binding, OB-fold-like protein. (566 aa)
T22A15.5F-box family protein. (80 aa)
RFC1Replication factor C subunit 1; Plays a role as mediator of transcriptional gene silencing (TGS), DNA replication, DNA repair, hypersensitive response (HR) and telomere length regulation. Is required in meiosis for DNA double- strand break (DSB) repair during meiotic homologous recombination. May participate in the RAD51-mediated recombination intermediate repair process. Is important for lagging strand synthesis. Promotes meiotic recombination via a specific pathway for crossovers (COs) that involves the formation of double Holliday Junction (dHJ) intermediates. (956 aa)
REV7DNA polymerase zeta processivity subunit; Regulatory subunit of the error prone DNA polymerase zeta. Involved in damage-tolerance mechanisms through translesion DNA synthesis (By similarity). (215 aa)
NAC089NAC domain-containing protein 89; Transcription factor involved in plant cell division. (340 aa)
RFC4Replication factor C subunit 4; May be involved in DNA replication and thus regulate cell proliferation; Belongs to the activator 1 small subunits family. (339 aa)
RFC3Replication factor C subunit 3; May be involved in DNA replication and thus regulate cell proliferation. (354 aa)
NAC074NAC domain containing protein 74. (352 aa)
REV3DNA polymerase zeta catalytic subunit; Catalytic subunit of the error prone DNA polymerase zeta. Involved in damage-tolerance mechanisms through translesion DNA synthesis. (1890 aa)
POLKDNA polymerase kappa; Template-directed low-fidelity DNA polymerase specifically involved in DNA repair. Able to extend primer-terminal mispairs, and to insert nucleotides opposite to a single 7,8-dihydro-8-oxoGuanine (8-oxoG) lesion and moderately extend from the resulting primer end, thus leading to both error-free and error-prone bypass of 8-oxoG DNA lesions. Probably involved in consecutive DNA replication cycles in the absence of mitosis. Binds preferentially template-primer DNA substrates or single-stranded DNA. Plays an important role in translesion synthesis, where the normal h [...] (671 aa)
T4C15.5F-box protein At2g35280. (163 aa)
Q058G7_ARATHF-box family protein. (114 aa)
RPS27AAUbiquitin-40S ribosomal protein S27a-1; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (156 aa)
RPS27ACUbiquitin-40S ribosomal protein S27a-3; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (157 aa)
RPS27ABUbiquitin-40S ribosomal protein S27a-2; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (157 aa)
T13D8.25NAC (No Apical Meristem) domain transcriptional regulator superfamily protein. (318 aa)
NAC024NAC domain containing protein 24. (320 aa)
T13D8.21NAC (No Apical Meristem) domain transcriptional regulator superfamily protein. (371 aa)
T13D8.18NAC (No Apical Meristem) domain transcriptional regulator superfamily protein. (322 aa)
ANAC023NAC domain containing protein 23. (347 aa)
STIProtein STICHEL; Acts as a key regulator of trichome branching through an endoreduplication-independent pathway. (1218 aa)
MRA19.13Protein STICHEL-like 4. (966 aa)
RPA1EReplication protein A 70 kDa DNA-binding subunit E; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (By similarity). (784 aa)
F22K18.10Protein STICHEL-like 2; Belongs to the DnaX/STICHEL family. (857 aa)
F28A21.230Protein STICHEL-like 3; Belongs to the DnaX/STICHEL family. (1097 aa)
NTL9Protein NTM1-like 9; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Calmodulin-regulated transcriptional repressor. Binds several synthetic promoters with randomly selected binding sites. Functions synergistically with SNI1 as negative regulator of pathogen-induced PR1 expression and basal resistance to a virulent strain of P.syringae. Binds directly to the promoter of the PR1 gene. Acts as positive regulator of innate immunity. Involved in the effector-triggered immunity (ETI) induction of immunity-related gene expression [...] (512 aa)
F4JA83_ARATHNucleic acid-binding proteins superfamily. (309 aa)
F4IHC4_ARATHNucleic acid-binding, OB-fold-like protein. (532 aa)
MEE13Myosin heavy chain-like protein. (652 aa)
F28J9.5Nucleic acid-binding proteins superfamily. (351 aa)
F4HXC5_ARATHF-box protein. (243 aa)
F4HWA5_ARATHE3 ubiquitin ligase. (170 aa)
F14L17.24Protein STICHEL-like 1. (1116 aa)
NAC014NAC domain-containing protein 14; Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). (652 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair and translesion synthesis (TLS). Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. Mediates also the insertion of dTMP or dGMP when the opposite base is G, and, with a low efficiency, dGMP insertions opposite G, T, and C, dAMP insertions opposite G, A, and T, and dTMP insertion opposite A. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemi [...] (1105 aa)
A0A1P8BD70Nucleic acid-binding, OB-fold-like protein. (192 aa)
A0A1P8B3C0Replication-like protein. (139 aa)
A0A1P8ARQ6Uncharacterized protein. (1041 aa)
A0A1I9LT28Uncharacterized protein. (248 aa)
A0A1I9LQI3Replication protein A1. (177 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.