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RPS27AC RPS27AC RPS27AB RPS27AB PP2A4 PP2A4 PAD1 PAD1 FH21A FH21A FH15A FH15A BRIZ2 BRIZ2 MKK4 MKK4 MKK3 MKK3 PAD2 PAD2 PBE1 PBE1 PBB1 PBB1 PP2A5 PP2A5 B'BETA B'BETA B'ALPHA B'ALPHA PHB3 PHB3 PA200 PA200 F4JC80_ARATH F4JC80_ARATH F4IXH9_ARATH F4IXH9_ARATH BRIZ1 BRIZ1 B'DELTA B'DELTA ARL2 ARL2 B'EPSILON B'EPSILON F3F19.7 F3F19.7 MKK2 MKK2 MKK8 MKK8 F5K20_270 F5K20_270 PHB5 PHB5 FTA FTA FH13 FH13 B'ZETA B'ZETA B'ETA B'ETA MKK10 MKK10 MKK7 MKK7 PHB4 PHB4 PBE2 PBE2 MKK9 MKK9 MKK6 MKK6 MVP7.5 MVP7.5 MKK1 MKK1 B'KAPPA B'KAPPA T21H19.130 T21H19.130 MKK5 MKK5 B'GAMMA B'GAMMA B'THETA B'THETA FACE2 FACE2 PBB2 PBB2 T1N15.15 T1N15.15 PP2AA3 PP2AA3 PP2AA2 PP2AA2 FTB FTB PP2AA1 PP2AA1 PP2A3 PP2A3 PP2A1-2 PP2A1-2 PP2A2-2 PP2A2-2 RPS27AA RPS27AA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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RPS27ACUbiquitin-40S ribosomal protein S27a-3; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (157 aa)
RPS27ABUbiquitin-40S ribosomal protein S27a-2; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (157 aa)
PP2A4Serine/threonine-protein phosphatase PP2A-4 catalytic subunit; Functions redundantly with PP2A3, and is involved in establishing auxin gradients, apical-basal axis of polarity and root and shoot apical meristem during embryogenesis. May dephosphorylate PIN1 and regulate its subcellular distribution for polar auxin transport. The holoenzyme composed of PP2AA1, PP2A4 and B'ZETA or B'ETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface- localized immune receptor complexes. Belongs to the PPP phosphatase family. PP-2A s [...] (313 aa)
PAD1Proteasome subunit alpha type-7-A; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the association of the SCF(TIR1) E3 ubiquitin ligase complex with the proteasome. (250 aa)
FH21APutative formin-like protein 21a; Belongs to the formin-like family. Class-II subfamily. (438 aa)
FH15AFormin-like protein 15a; Belongs to the formin-like family. Class-II subfamily. (405 aa)
BRIZ2BRAP2 RING ZnF UBP domain-containing protein 2; RING-type ubiquitin E3 ligase that binds ubiquitin and is required for seed germination and post-germination growth. (479 aa)
MKK4Mitogen-activated protein kinase kinase 4; Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the [...] (366 aa)
MKK3Mitogen-activated protein kinase kinase 3; MKK3-MPK6 module plays an important role in the jasmonate signal transduction pathway through the negative regulation of MYC2/JIN1 expression. Activates by phosphorylation the downstream MPK6, MPK7 and MPK8. MKK3-MPK7 module acts as a positive regulator of PR1 gene expression. MKK3-MPK8 module negatively regulates ROS accumulation through controlling expression of the RBOHD gene. Component of the abscisic acid (ABA) signaling pathway that may act as ABA signal transducer in the context of abiotic stresses. Activator of the C group MAP kinases. [...] (520 aa)
PAD2Proteasome subunit alpha type-7-B; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1A family. (250 aa)
PBE1Proteasome subunit beta type-5-A; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1B family. (274 aa)
PBB1Proteasome subunit beta type-7-A; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1B family. (273 aa)
PP2A5Serine/threonine-protein phosphatase PP2A-5 catalytic subunit; Associates with the serine/threonine-protein phosphatase PP2A regulatory subunits A and B' to positively regulates beta-oxidation of fatty acids and protoauxins in peroxisomes by dephosphorylating peroxisomal beta-oxidation-related proteins. Involved in the positive regulation of salt stress responses. May function by increasing chloride channel activities on vacuolar membranes. (307 aa)
B'BETASerine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Required for the formation of the PP2A holoenzyme that positively regulates brassinosteroid signaling by dephosphorylating and activating BZR1. (499 aa)
B'ALPHASerine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Required for the formation of the PP2A holoenzyme that positively regulates brassinosteroid signaling by dephosphorylating and activating BZR1. (495 aa)
PHB3Prohibitin-3, mitochondrial; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins (By similarity). Necessary for mitochondrial and cell metabolism and biogenesis. Required to regulate the ethylene-mediated signaling; involved in growth maintenance in the presence of ethylene. Functions in nitric oxide (NO)-mediated responses and in hydrogen peroxide- induced NO accumulation. (277 aa)
PA200Proteasome activator subunit 4; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved in DNA d [...] (1811 aa)
F4JC80_ARATHWW domain-containing protein. (892 aa)
F4IXH9_ARATHARM repeat superfamily protein. (551 aa)
BRIZ1BRAP2 RING ZnF UBP domain-containing protein 1; RING-type ubiquitin E3 ligase required for seed germination and post-germination growth. (488 aa)
B'DELTASerine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. (477 aa)
ARL2ADP-ribosylation factor-like protein 2; Has a role in the cofactor-dependent pathway of microtubule biogenesis. Not essential for cell viability. May play a regulatory role in sequestring TFCD; Belongs to the small GTPase superfamily. Arf family. (185 aa)
B'EPSILONSerine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. (497 aa)
F3F19.7Proline-rich receptor-like kinase. (317 aa)
MKK2Mitogen-activated protein kinase kinase 2; MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Plays a role in abiotic stress tolerance and plant disease resistance through activation of MPK4 and MPK6 by phosphorylation. Acts redundantly with MKK1. (363 aa)
MKK8Mitogen-activated protein kinase kinase 8; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (309 aa)
F5K20_270Probable proteasome inhibitor; Could play an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome (By similarity); Belongs to the proteasome inhibitor PI31 family. (302 aa)
PHB5Prohibitin-5, mitochondrial; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. (249 aa)
FTAProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. (326 aa)
FH13Formin-like protein 13; Belongs to the formin-like family. Class-II subfamily. (1266 aa)
B'ZETASerine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). The holoenzyme composed of PP2AA1, PP2A4 and B'ZETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes. Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signal [...] (546 aa)
B'ETASerine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). The holoenzyme composed of PP2AA1, PP2A4 and B'ETA acts as negative regulator of plant innate immunity by controlling BAK1 phosphorylation state and activation in surface-localized immune receptor complexes. Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signalin [...] (510 aa)
MKK10Mitogen-activated protein kinase kinase 10; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. (305 aa)
MKK7Mitogen-activated protein kinase kinase 7; May function as a negative regulator of polar auxin transport. Positively regulates plant basal and systemic acquired resistance (SAR). Activates MPK3 and MPK6 in vitro. (307 aa)
PHB4Prohibitin-4, mitochondrial; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. (279 aa)
PBE2Proteasome subunit beta type-5-B; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1B family. (273 aa)
MKK9Mitogen-activated protein kinase kinase 9; MKK9-MPK3/MPK6 module phosphorylates and activates EIN3, leading to the promotion of EIN3-mediated transcription in ethylene signaling. Autophosphorylates and also phosphorylates MPK3 and MPK6. Plays an important role in ethylene and camalexin biosynthesis and in salt stress response. MKK9-MPK6 module positively regulates leaf senescence. (310 aa)
MKK6Mitogen-activated protein kinase kinase 6; The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. MKK6-MPK13 module positively regulates lateral root formation. Phosphorylates and activates MPK4. Activates MPK5 and MPK13 in vitro. (356 aa)
MVP7.5Transducin/WD40 repeat-like superfamily protein. (299 aa)
MKK1Mitogen-activated protein kinase kinase 1; MEKK1, MKK1/MKK2 and MPK4/MPK6 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Activates by phosphorylation the downstream MPK4. Acts redundantly with MKK2. MKK1-MPK6 module mediates abscisic acid (ABA)-dependent CAT1 expression with H(2)O(2) production and response to drought and salt stress. MKK1-MPK6 module is also involved in sugar signaling during the process of seed germination. (354 aa)
B'KAPPASerine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. (500 aa)
T21H19.130HEAT repeat-containing protein. (1180 aa)
MKK5Mitogen-activated protein kinase kinase 5; Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the [...] (348 aa)
B'GAMMASerine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Required for the formation of the PP2A holoenzyme that negatively regulates brassinosteroid signaling by dephosphorylating and inactivating BRI1 in the cytoplasm. Seems to be functionally connected with CPR5 and may mediate the negative regulation of defense reactions and senescence under low irradiances. [...] (522 aa)
B'THETASerine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform; The B regulatory subunit may modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). Associates with the serine/threonine-protein phosphatase PP2A catalytic subunit C and regulatory subunit A to positively regulates beta-oxidation of fatty acids and protoauxins in peroxisomes by dephosphorylating peroxisomal beta-oxidation-related proteins. Required for the formation of the PP2A holoenzym [...] (492 aa)
FACE2CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. The substrate specificity is only partially overlapping with that of FACE1. Belongs to the peptidase U48 family. (311 aa)
PBB2Proteasome subunit beta type-7-B; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (274 aa)
T1N15.15Proteasome inhibitor-like protein. (175 aa)
PP2AA3Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform; The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Involved during developmental process such as seedling and floral developments. Seems to act as a negative regulator of PP2A catalytic activity. (587 aa)
PP2AA2Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Involved during developmental process such as seedling and floral developments. Seems to act as a negative regulator of PP2A catalytic activity. Associates with the serine/threonine-protein phosphatase PP2A catalytic subunit C and regulatory subunit B' to positively regulates beta-oxidation of fatty acids and protoauxins in peroxisomes by dephosp [...] (587 aa)
FTBProtein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X (CaaX). The beta subunit is responsible for peptide- binding. (482 aa)
PP2AA1Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The A subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Seems to act as a positive regulator of PP2A catalytic activity. Confers resistance to phosphatase inhibitors such as okadaic acid and cantharidin. Involved during developmental process such as seedling and floral developments, root gravitropism, and stomatal opening regulation. Involved in the regulation of auxin efflux, especially during basip [...] (588 aa)
PP2A3Serine/threonine-protein phosphatase PP2A-3 catalytic subunit; Functions redundantly with PP2A4, and is involved in establishing auxin gradients, apical-basal axis of polarity and root and shoot apical meristem during embryogenesis. May dephosphorylate PIN1 and regulate its subcellular distribution for polar auxin transport. Involved in the regulation of formative cell division in roots by dephosphorylating ACR4 protein kinase. (313 aa)
PP2A1-2Serine/threonine-protein phosphatase PP2A-1 catalytic subunit; Belongs to the PPP phosphatase family. PP-2A subfamily. (306 aa)
PP2A2-2Serine/threonine-protein phosphatase PP2A-2 catalytic subunit; Dephosphorylates and activates the actin-depolymerizing factor ADF1, which, in turn, regulates actin cytoskeleton remodeling and is involved in the blue light photoreceptor PHOT2-mediated chloroplast avoidance movements. Associates with the serine/threonine-protein phosphatase PP2A regulatory subunits A and B' to positively regulates beta-oxidation of fatty acids and protoauxins in peroxisomes by dephosphorylating peroxisomal beta-oxidation-related proteins. Acts as negative regulator of abscisic acid (ABA) signaling. May r [...] (306 aa)
RPS27AAUbiquitin-40S ribosomal protein S27a-1; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is invol [...] (156 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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