STRINGSTRING
NET2A NET2A TBP1 TBP1 TBP2 TBP2 EMB1674 EMB1674 NRPB10 NRPB10 TFB4 TFB4 T29F13.4 T29F13.4 Q9LIF6_ARATH Q9LIF6_ARATH F4P12.350 F4P12.350 XPB2 XPB2 MPO12.30 MPO12.30 NRPB12 NRPB12 MEE6.9 MEE6.9 NRPB5L1 NRPB5L1 NRPB6A NRPB6A UMAMIT7 UMAMIT7 HTB2 HTB2 NRPB12L NRPB12L F10A5.14 F10A5.14 TFB5 TFB5 Q6DYC0_ARATH Q6DYC0_ARATH TFB2 TFB2 TFB1-1 TFB1-1 CYCH1-1 CYCH1-1 HTB1 HTB1 F8A5.14 F8A5.14 XPB1 XPB1 T16B24.12 T16B24.12 Q1G3U4_ARATH Q1G3U4_ARATH Q9LU97_ARATH Q9LU97_ARATH Q9LVK6_ARATH Q9LVK6_ARATH T22P11.160 T22P11.160 HTB11 HTB11 NRPB8B NRPB8B NRPE5C NRPE5C NRPE5A NRPE5A TFB1-3 TFB1-3 F11F8.5 F11F8.5 T23G18.3 T23G18.3 T11P11.3 T11P11.3 NRPB6B NRPB6B NRPA1 NRPA1 NRPB10L NRPB10L F3G5.26 F3G5.26 NRPD5B NRPD5B GTF2H2 GTF2H2 F14B2.16 F14B2.16 T5I8.4 T5I8.4 A0A1P8AQ67 A0A1P8AQ67 AAC42 AAC42 K15N18.8 K15N18.8 B3H572_ARATH B3H572_ARATH NET2B NET2B NRPA2 NRPA2 XPD XPD F4J2R9_ARATH F4J2R9_ARATH UMAMIT8 UMAMIT8 MWF20.21 MWF20.21 KNL2 KNL2 H2B H2B HTB4 HTB4 NRPB8A NRPB8A NRPB5A NRPB5A
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
NET2AProtein NETWORKED 2A; Plant-specific actin binding protein. Associates with F-actin at the plasma membrane in growing pollen tubes. May be part of a membrane-cytoskeletal adapter complex; Belongs to the NET family. (947 aa)
TBP1TATA-box-binding protein 1; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. (200 aa)
TBP2TATA-box-binding protein 2; General transcription factor (GTF) that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). Interacts with TFIIB1 and is required for activated transcription and possibly basal transcription. May act as GTF of RNA polymerase I- dependent transcription and rRNA synthesis. Forms a ternary complex with PBRP1 and the rDNA promoter region. Be [...] (200 aa)
EMB1674Protein EMBRYO DEFECTIVE 1674; Required for normal embryo development. (281 aa)
NRPB10DNA-directed RNA polymerases II, IV and V subunit 10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependen [...] (71 aa)
TFB4General transcription and DNA repair factor IIH subunit TFB4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been [...] (301 aa)
T29F13.4RNA polymerase I specific transcription initiation factor RRN3 protein. (613 aa)
Q9LIF6_ARATHDynein beta chain, ciliary protein. (188 aa)
F4P12.350Histone H2B.8; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (138 aa)
XPB2General transcription and DNA repair factor IIH helicase subunit XPB2; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB, but not its helicase activity, is required for DNA [...] (766 aa)
MPO12.30Cysteine/Histidine-rich C1 domain family protein. (594 aa)
NRPB12DNA-directed RNA polymerases II, IV and V subunit 12; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependen [...] (51 aa)
MEE6.9Myb family transcription factor. (588 aa)
NRPB5L1DNA-directed RNA polymerase subunit 5-like protein 1. (210 aa)
NRPB6ADNA-directed RNA polymerases II, IV and V subunit 6A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependen [...] (144 aa)
UMAMIT7WAT1-related protein At5g47470. (364 aa)
HTB2Histone H2B.10; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)
NRPB12LDNA-directed RNA polymerase subunit 12-like protein. (61 aa)
F10A5.14DNA-directed RNA polymerase. (196 aa)
TFB5General transcription and DNA repair factor IIH subunit TFB5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been [...] (71 aa)
Q6DYC0_ARATHUncharacterized protein. (241 aa)
TFB2General transcription and DNA repair factor IIH subunit TFB2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been [...] (452 aa)
TFB1-1General transcription and DNA repair factor IIH subunit TFB1-1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (591 aa)
CYCH1-1Cyclin-H1-1; Associates with CDK-2 and CDK-3 and activates the CDK kinases. (336 aa)
HTB1Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (148 aa)
F8A5.14RNA polymerase subunit (Isoform B). (385 aa)
XPB1General transcription and DNA repair factor IIH helicase subunit XPB1; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB, but not its helicase activity, is required for DNA [...] (767 aa)
T16B24.12RNA polymerase I specific transcription initiation factor RRN3 family protein. (573 aa)
Q1G3U4_ARATHDNA-directed RNA polymerase I subunit RPA12-like protein. (91 aa)
Q9LU97_ARATHDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (119 aa)
Q9LVK6_ARATHDNA binding / DNA-directed RNA polymerase. (442 aa)
T22P11.160Histone H2B.9; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (132 aa)
HTB11Histone H2B.7; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)
NRPB8BDNA-directed RNA polymerases II, IV and V subunit 8B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependen [...] (146 aa)
NRPE5CDNA-directed RNA polymerase V subunit 5C; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase V involved in RNA-directed DNA methylation- dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (233 aa)
NRPE5ADNA-directed RNA polymerase V subunit 5A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase V involved in RNA-directed DNA methylation- dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements. Required for establishment of DNA methylation. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (222 aa)
TFB1-3General transcription and DNA repair factor IIH subunit TFB1-3; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (579 aa)
F11F8.5Histone H2B.5; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
T23G18.3Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (243 aa)
T11P11.3Histone H2B.3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (151 aa)
NRPB6BDNA-directed RNA polymerases II and V subunit 6B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerase V which mediates RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated s [...] (144 aa)
NRPA1DNA-directed RNA polymerase I subunit 1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from NRPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of [...] (1670 aa)
NRPB10LDNA-directed RNA polymerase subunit 10-like protein; Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (71 aa)
F3G5.26Histone H2B.4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (138 aa)
NRPD5BDNA-directed RNA polymerases IV and V subunit 5B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation- dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (218 aa)
GTF2H2General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (421 aa)
F14B2.16Cysteine/Histidine-rich C1 domain family protein. (538 aa)
T5I8.4RNA polymerase I specific transcription initiation factor RRN3 protein. (607 aa)
A0A1P8AQ67Uncharacterized protein. (340 aa)
AAC42DNA-directed RNA polymerase family protein. (375 aa)
K15N18.8Myb-like protein X. (484 aa)
B3H572_ARATHNucleotide excision repair, TFIIH, subunit TTDA. (72 aa)
NET2BProtein NETWORKED 2B; Plant-specific actin binding protein. May be part of a membrane-cytoskeletal adapter complex. (928 aa)
NRPA2DNA-directed RNA polymerase I subunit 2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and NRPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. (1178 aa)
XPDGeneral transcription and DNA repair factor IIH helicase subunit XPD; ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD is required for DNA opening. In tran [...] (758 aa)
F4J2R9_ARATHDNA binding / DNA-directed RNA polymerase. (87 aa)
UMAMIT8WAT1-related protein At4g16620. (359 aa)
MWF20.21Myb-like protein X. (185 aa)
KNL2Kinetochore-associated protein KNL-2 homolog; Involved in recognition of centromeres and centromeric localization of the centromere-specific histone HTR12/CENH3. Required for normal progression of mitosis and meiosis. May play a role in the determination of the epigenetic status of centromeres. Binds DNA and RNA in vitro. Belongs to the KNL2 family. (598 aa)
H2BHistone H2B.6; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (150 aa)
HTB4Histone H2B.11; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (150 aa)
NRPB8ADNA-directed RNA polymerases II and V subunit 8A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerase V which mediates RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated s [...] (146 aa)
NRPB5ADNA-directed RNA polymerases II and IV subunit 5A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. Component of RNA polymerase IV which mediates short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) [...] (205 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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