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D2HGDH | D-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of (R)-2-hydroxyglutarate to 2- oxoglutarate. May be involved in the catabolism of propionyl-CoA derived from beta-oxidation. Involved in degradation of lysine for the supply of carbon and electrons to the ETF/ETFQO complex during dark- induced sugar starvation; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (559 aa) | ||||
L2HGDH | L-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of (S)-2-hydroxyglutarate to 2- oxoglutarate. Is specific for the (S) enantiomer and possesses very poor activity toward (R)-2-hydroxyglutarate. Has no activity toward related 2-hydroxy acids, such as glycolate, L-lactate or D-lactate. Belongs to the L2HGDH family. (483 aa) |