STRINGSTRING
LACS2 LACS2 LACS4 LACS4 LACS5 LACS5 AEE9 AEE9 AAE16 AAE16 AAE6 AAE6 AAE5 AAE5 AAE20 AAE20 AAE12 AAE12 LACS9 LACS9 AAE15 AAE15 LACS3 LACS3 AAE11 AAE11 AEE22 AEE22 AAE3 AAE3 LACS8 LACS8 AEE21 AEE21 AAE2 AAE2 4CL3 4CL3 4CL2 4CL2 4CLL7 4CLL7 4CL4 4CL4 AAE8 AAE8 4CLL1 4CLL1 AEE10 AEE10 4CLL5 4CLL5 AAE18 AAE18 4CLL3 4CLL3 4CLL4 4CLL4 4CLL9 4CLL9 4CLL6 4CLL6 4CLL2 4CLL2 4CLL8 4CLL8 AAE13 AAE13 LACS7 LACS7 LACS6 LACS6 AAE14 AAE14 AAE7 AAE7 AEE4 AEE4 LACS1 LACS1 AAE17 AAE17 F14A1.10 F14A1.10 AAE1 AAE1 ACS ACS 4CL1 4CL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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LACS2Long chain acyl-CoA synthetase 2; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in the cutin pathway. Preferentially uses palmitate, palmitoleate, oleate and linoleate. Required for repression of lateral root formation through its role in cutin biosynthesis and subsequent aerial tissues permeability. Belongs to the ATP-dependent AMP-binding enzyme family. (665 aa)
LACS4Long chain acyl-CoA synthetase 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (666 aa)
LACS5Long chain acyl-CoA synthetase 5; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (666 aa)
AEE9Probable acyl-activating enzyme 9; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs; Belongs to the ATP-dependent AMP-binding enzyme family. (550 aa)
AAE16Probable acyl-activating enzyme 16, chloroplastic; May be involved in the activation of fatty acids to acyl- carrier-protein; Belongs to the ATP-dependent AMP-binding enzyme family. (722 aa)
AAE6Probable acyl-activating enzyme 6; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs; Belongs to the ATP-dependent AMP-binding enzyme family. (550 aa)
AAE5Probable acyl-activating enzyme 5, peroxisomal; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs. (552 aa)
AAE20Benzoate--CoA ligase, peroxisomal; Benzoate--CoA ligase involved in benzoyloxyglucosinolate biosynthesis in seeds. Glucosinolates are secondary metabolites involved in pathogen and insect defense of cruciferous plants. (580 aa)
AAE12Probable acyl-activating enzyme 12, peroxisomal; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs. (578 aa)
LACS9Long chain acyl-CoA synthetase 9, chloroplastic; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate. (691 aa)
AAE15Long-chain-fatty-acid--[acyl-carrier-protein] ligase AEE15, chloroplastic; Probably involved in the activation of fatty acids to acyl- carrier-protein prior to fatty acid elongation in plastids. Acts on medium- to long-chain fatty acids. (727 aa)
LACS3Long chain acyl-CoA synthetase 3; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (665 aa)
AAE11Butyrate--CoA ligase AAE11, peroxisomal; Butyrate--CoA ligase that is active in vitro with medium- chain fatty acids, with a preference for hexanoate and octanoate. Belongs to the ATP-dependent AMP-binding enzyme family. (572 aa)
AEE22Probable acyl-activating enzyme 22; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs. (535 aa)
AAE3Oxalate--CoA ligase; Oxalyl-CoA synthetase acting exclusively against oxalate. No activity with malonate, succinate, malate, acetate, formate, lactate, glycolate, glyoxylate or glutarate. Required for oxalate degradation, normal seed development and defense against oxalate-producing fungal pathogens. (514 aa)
LACS8Long chain acyl-CoA synthetase 8; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate and linoleate; Belongs to the ATP-dependent AMP-binding enzyme family. (720 aa)
AEE21Probable acyl-activating enzyme 21; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs. (546 aa)
AAE2Probable acyl-activating enzyme 2; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs; Belongs to the ATP-dependent AMP-binding enzyme family. (603 aa)
4CL34-coumarate--CoA ligase 3; Produces CoA thioesters of a variety of hydroxy- and methoxy- substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics; Belongs to the ATP-dependent AMP-binding enzyme family. (561 aa)
4CL24-coumarate--CoA ligase 2; Produces CoA thioesters of a variety of hydroxy- and methoxy- substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics. (556 aa)
4CLL74-coumarate--CoA ligase-like 7; Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors. (544 aa)
4CL44-coumarate--CoA ligase 4; Produces CoA thioesters of a variety of hydroxy- and methoxy- substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics. (570 aa)
AAE8Probable acyl-activating enzyme 8; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs; Belongs to the ATP-dependent AMP-binding enzyme family. (544 aa)
4CLL14-coumarate--CoA ligase-like 1; Belongs to the ATP-dependent AMP-binding enzyme family. (542 aa)
AEE10Probable acyl-activating enzyme 10; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs. (549 aa)
4CLL54-coumarate--CoA ligase-like 5; Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors. Converts 12-oxo- phytodienoic acid (OPDA) and 3-oxo-2-(2'-pentenyl)-cyclopentane-1- octanoic acid (OPC-8:0) into OPDA-CoA and OPC-8:0-CoA, respectively; Belongs to the ATP-dependent AMP-binding enzyme family. (546 aa)
AAE18Probable acyl-activating enzyme 18, peroxisomal; May be involved in the peroxisomal activation of 2,4- dichlorophenoxybutyric acid (2,4-DB), a precursor of active auxins that inhibit root growth. (727 aa)
4CLL34-coumarate--CoA ligase-like 3. (552 aa)
4CLL44-coumarate--CoA ligase-like 4; Belongs to the ATP-dependent AMP-binding enzyme family. (550 aa)
4CLL94-coumarate--CoA ligase-like 9; Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors. Converts 12-oxo- phytodienoic acid (OPDA) into OPDA-CoA; Belongs to the ATP-dependent AMP-binding enzyme family. (562 aa)
4CLL64-coumarate--CoA ligase-like 6; Belongs to the ATP-dependent AMP-binding enzyme family. (566 aa)
4CLL24-coumarate--CoA ligase-like 2; Belongs to the ATP-dependent AMP-binding enzyme family. (565 aa)
4CLL84-coumarate--CoA ligase-like 8. (550 aa)
AAE13Malonate--CoA ligase; Malonate--CoA ligase that catalyzes the formation of malonyl- CoA directly from malonate and CoA. May be required for the detoxification of malonate; Belongs to the ATP-dependent AMP-binding enzyme family. (608 aa)
LACS7Long chain acyl-CoA synthetase 7, peroxisomal; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Displays redundant function with LACS7 into the seed development process (By similarity). (700 aa)
LACS6Long chain acyl-CoA synthetase 6, peroxisomal; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Might play a regulatory role both in fatty acid import into glyoxysomes and in fatty acid beta-oxidation. Displays redundant function with LACS7 into the seed development process. (701 aa)
AAE142-succinylbenzoate--CoA ligase, chloroplastic/peroxisomal; Involved in the biosynthesis of phylloquinone (vitamin K1). Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). (560 aa)
AAE7Acetate/butyrate--CoA ligase AAE7, peroxisomal; Peroxisomal acetate/butyrate--CoA ligase that is probably involved in the activation of exogenous acetate for entry into the glyoxylate cycle. May play a role to prevent carbon loss from peroxisomes during lipid mobilization. In vitro, is active with both acetate and butyrate. Belongs to the ATP-dependent AMP-binding enzyme family. (569 aa)
AEE4Probable acyl-activating enzyme 4; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs; Belongs to the ATP-dependent AMP-binding enzyme family. (545 aa)
LACS1Long chain acyl-CoA synthetase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Acts in both the wax and cutin pathways. Preferentially uses palmitate, palmitoleate, linoleate and eicosenoate. Seems to have a specific activity against very long-chain fatty acid (VLCFA) class with acids longer than 24 carbons (C(24)). (660 aa)
AAE17Probable acyl-activating enzyme 17, peroxisomal; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs; Belongs to the ATP-dependent AMP-binding enzyme family. (721 aa)
F14A1.10Putative acyl-activating enzyme 19; Belongs to the ATP-dependent AMP-binding enzyme family. (1040 aa)
AAE1Probable acyl-activating enzyme 1, peroxisomal; May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs; Belongs to the ATP-dependent AMP-binding enzyme family. (556 aa)
ACSAcetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; Catalyzes the production of acetyl-CoA, an activated form of acetate that can be used for lipid synthesis or for energy generation. May play a limited role in the biosynthesis of lipids. Belongs to the ATP-dependent AMP-binding enzyme family. (743 aa)
4CL14-coumarate--CoA ligase 1; Produces CoA thioesters of a variety of hydroxy- and methoxy- substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics; Belongs to the ATP-dependent AMP-binding enzyme family. (561 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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