STRINGSTRING
CYCA2-4 CYCA2-4 CYCA3-2 CYCA3-2 RBX1A RBX1A CYCA3-4 CYCA3-4 SKP1A SKP1A CYCA2-1 CYCA2-1 CYCA2-3 CYCA2-3 CYCA2-2 CYCA2-2 UBC14 UBC14 UBC3 UBC3 A0A1I9LSE2 A0A1I9LSE2 CYCA3-3 CYCA3-3 MET4 MET4 ABCF4 ABCF4 ELC ELC CYCA1-2 CYCA1-2 CYCA3-1 CYCA3-1 MNC17.5 MNC17.5 CDKA-1 CDKA-1 CYCA1-1 CYCA1-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYCA2-4Cyclin-A2-4; Belongs to the cyclin family. Cyclin AB subfamily. (461 aa)
CYCA3-2Cyclin-A3-2; Belongs to the cyclin family. Cyclin AB subfamily. (372 aa)
RBX1ARING-box protein 1a; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL1. Belongs to the RING-box family. (118 aa)
CYCA3-4Cyclin-A3-4; Belongs to the cyclin family. Cyclin AB subfamily. (370 aa)
SKP1ASKP1-like protein 1A; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicate [...] (160 aa)
CYCA2-1Cyclin-A2-1; May negatively regulate endocycles and act as a regulator of ploidy levels in endoreduplication; Belongs to the cyclin family. Cyclin AB subfamily. (443 aa)
CYCA2-3Cyclin-A2-3; Negatively regulates endocycles and acts as a regulator of ploidy levels in endoreduplication. Promotes divisions in the guard cells (GCs) after the guard mother cells (GMC) symmetric division ; Belongs to the cyclin family. Cyclin AB subfamily. (450 aa)
CYCA2-2Cyclin-A2-2. (436 aa)
UBC14Ubiquitin-conjugating enzyme E2 14; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation. (167 aa)
UBC3Ubiquitin-conjugating enzyme E2 3; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. (150 aa)
A0A1I9LSE2Cyclin B1. (100 aa)
CYCA3-3Cyclin-A3-3; Belongs to the cyclin family. Cyclin AB subfamily. (327 aa)
MET4DNA (cytosine-5)-methyltransferase 4; Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells (By similarity). (1519 aa)
ABCF4ABC transporter F family member 4; Belongs to the ABC transporter superfamily. ABCF family. EF3 (TC 3.A.1.121) subfamily. (723 aa)
ELCProtein ELC; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). May control nuclear division through the microtubule cytoskeleton; Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. (398 aa)
CYCA1-2Cyclin-A1-2; Involved in the regulation of male meiosis progression. (442 aa)
CYCA3-1Putative cyclin-A3-1; Belongs to the cyclin family. Cyclin AB subfamily. (355 aa)
MNC17.5BTB/POZ domain-containing protein; Belongs to the SKP1 family. (96 aa)
CDKA-1Cyclin-dependent kinase A-1; Involved in the control of the cell cycle. Essential for both G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis. Required to trigger guard mother cells (GMC) symmetric divisions at the late stage of stomatal development, probably via the regulation of G1 to S transition in the cell cycle. Required for the function of SPCH in entering the stomatal lineage. Promotes divisions in the guard cells (GCs) after the gu [...] (294 aa)
CYCA1-1Cyclin-A1-1; Belongs to the cyclin family. Cyclin AB subfamily. (460 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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