STRINGSTRING
M3E9.180 M3E9.180 T28K15.4 T28K15.4 VAD1 VAD1 A0A1P8ARU2 A0A1P8ARU2 PGD1 PGD1 LAC5 LAC5 F1O11.21 F1O11.21 PDC2 PDC2 PGD3 PGD3 MBK5.16 MBK5.16 Q94KE3_ARATH Q94KE3_ARATH PKP3 PKP3 PGI1 PGI1 ATHXK4 ATHXK4 HXK1 HXK1 HXK2 HXK2 PGD2 PGD2 HXK3 HXK3 PKP1 PKP1 LAC1 LAC1 HKL1 HKL1 Q9LU95_ARATH Q9LU95_ARATH TRA2 TRA2 PDC3 PDC3 PDC4 PDC4 F1I16_220 F1I16_220 F1I16_60 F1I16_60 PKP4 PKP4 TOR TOR PEX5 PEX5 MCD7.8 MCD7.8 PKP2 PKP2 MAH20.13 MAH20.13 HMGS HMGS PGIC PGIC PDC1 PDC1 HKL3 HKL3 T11I18.16 T11I18.16 GNTI GNTI LAC2 LAC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M3E9.180Probable pyruvate kinase, cytosolic isozyme; Key regulatory enzyme of the glycolytic pathway that catalyzes the final step of glycolysis, converting ADP and phosphoenolpyruvate (PEP) to ATP and pyruvate by essentially irreversible transphosphorylation. (497 aa)
T28K15.4Aldolase superfamily protein. (427 aa)
VAD1Protein VASCULAR ASSOCIATED DEATH 1, chloroplastic; Involved in ethylene- and salicylic acid-dependent cell death control associated with cells in the vicinity of vascular bundles. (598 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
PGD16-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (487 aa)
LAC5Laccase-5; Lignin degradation and detoxification of lignin-derived products. (580 aa)
F1O11.21Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
PDC2Pyruvate decarboxylase 2; Belongs to the TPP enzyme family. (607 aa)
PGD36-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (487 aa)
MBK5.16Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
Q94KE3_ARATHPyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
PKP3Plastidial pyruvate kinase 3, chloroplastic; Required for plastidial pyruvate kinase activity. (571 aa)
PGI1Glucose-6-phosphate isomerase 1, chloroplastic; Promotes the synthesis of starch in leaves. (613 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
PGD26-phosphogluconate dehydrogenase, decarboxylating 2; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Required for guided growth of the male gametophytes and interaction between the pollen tube and the ovule. (486 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
PKP1Plastidial pyruvate kinase 1, chloroplastic; Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination. (596 aa)
LAC1Laccase-1; Lignin degradation and detoxification of lignin-derived products. (581 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
Q9LU95_ARATHPyruvate kinase; Belongs to the pyruvate kinase family. (497 aa)
TRA2Aldolase-type TIM barrel family protein. (438 aa)
PDC3Pyruvate decarboxylase 3; Belongs to the TPP enzyme family. (592 aa)
PDC4Pyruvate decarboxylase 4; Belongs to the TPP enzyme family. (603 aa)
F1I16_220Pyruvate kinase; Belongs to the pyruvate kinase family. (492 aa)
F1I16_60Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
PKP4Plastidial pyruvate kinase 4, chloroplastic. (710 aa)
TORSerine/threonine-protein kinase TOR; Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival. Involved in modulating the transition from heterotrophic [...] (2481 aa)
PEX5Peroxisome biogenesis protein 5; Import receptor for peroxisomal-targeting signal one (PTS1). A receptor-cargo complex composed of PEX5, PEX7, a PTS1-containing protein and a PTS2-containing protein is targeted to peroxisomes during import. Necessary for the developmental elimination of obsolete peroxisome matrix proteins. (728 aa)
MCD7.8Pyruvate kinase; Belongs to the pyruvate kinase family. (498 aa)
PKP2Plastidial pyruvate kinase 2; Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination. (579 aa)
MAH20.13Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
HMGSHydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (461 aa)
PGICGlucose-6-phosphate isomerase, cytosolic; Belongs to the GPI family. (560 aa)
PDC1Pyruvate decarboxylase 1; May play a role in ethanolic fermentation during anoxia. Belongs to the TPP enzyme family. (607 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
T11I18.16Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
GNTIAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Required for normal root growth and morphology. (444 aa)
LAC2Laccase-2; Lignin degradation and detoxification of lignin-derived products (By similarity). Required for root elongation in dehydration conditions; Belongs to the multicopper oxidase family. (573 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.