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HMGB15 HMGB15 WUS WUS HMGB9 HMGB9 ADC1 ADC1 CEL2 CEL2 TRE1 TRE1 GILT GILT RPL14B RPL14B ARF11 ARF11 WOX6 WOX6 SAC1 SAC1 ERL1 ERL1 NAC098 NAC098 ATHB-40 ATHB-40 T29F13.9 T29F13.9 MEA MEA SPL SPL CAM1 CAM1 CAM2 CAM2 AGL5 AGL5 CML10 CML10 AP3 AP3 AP2 AP2 CAM7 CAM7 RAD51 RAD51 LFY LFY CAM6 CAM6 Q1H557_ARATH Q1H557_ARATH AGL11 AGL11 BEL1 BEL1 GA3OX1 GA3OX1 UBQ14 UBQ14 ATHB-22 ATHB-22 TIR1 TIR1 MSF3.23 MSF3.23 AHL25 AHL25 BT5 BT5 AIL5 AIL5 WOX8 WOX8 WOX2 WOX2 ERL2 ERL2 UBQ10 UBQ10 ATML1 ATML1 PDF2 PDF2 GID1C GID1C BT2 BT2 ARF18 ARF18 BZIP8 BZIP8 CP1 CP1 VDD VDD KAN4 KAN4 MRG7.5 MRG7.5 AFB3 AFB3 ATHB-53 ATHB-53 ATHB-51 ATHB-51 NGA2 NGA2 AHL15 AHL15
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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HMGB15High mobility group B protein 15; Binds preferentially DNA with A/T-rich content. Belongs to the HMGB family. (448 aa)
WUSProtein WUSCHEL; Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expr [...] (292 aa)
HMGB9High mobility group B protein 9; Binds preferentially DNA with A/T-rich content. Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. (338 aa)
ADC1Arginine decarboxylase 1; Required for the biosynthesis of putrescine. Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine. Is a minor contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis. Accumulation of putrescine plays a positive role in freezing tolerance. Production of polyamines is essential for normal seed development. Controls PA homeostasis which is crucial for normal plant growth and development. (702 aa)
CEL2Endoglucanase 1. (501 aa)
TRE1Trehalase; Involved in the regulation of trehalose content by hydrolyzing trehalose to glucose. (626 aa)
GILTGamma-interferon-responsive lysosomal thiol protein; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation; Belongs to the GILT family. (233 aa)
RPL14B60S ribosomal protein L14-2; Belongs to the eukaryotic ribosomal protein eL14 family. (134 aa)
ARF11Auxin response factor 11; Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. (622 aa)
WOX6WUSCHEL-related homeobox 6; Transcription factor that plays a central role in ovule patterning by regulating cell proliferation of the maternal integuments and differentiation of the maegaspore mother cell (MCC). Involved in AGAMOUS (AG) repression in leaves; Belongs to the WUS homeobox family. (271 aa)
SAC1Phosphoinositide phosphatase SAC1; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for normal cell morphogenesis, cell wall synthesis, and actin organization. (912 aa)
ERL1LRR receptor-like serine/threonine-protein kinase ERL1; Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ER and ERL2. Redundantly involved with ER in procambial development regulation. Forms a functional ligand-receptor pair with EPF1 (AC Q8S8I4). Forms a constitutive complex with TMM involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (966 aa)
NAC098Protein CUP-SHAPED COTYLEDON 2; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of [...] (375 aa)
ATHB-40Homeobox-leucine zipper protein ATHB-40; Probable transcription factor; Belongs to the HD-ZIP homeobox family. Class I subfamily. (216 aa)
T29F13.9Pollen Ole e 1 allergen and extensin family protein. (175 aa)
MEAHistone-lysine N-methyltransferase MEDEA; Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to prevent the proliferation of the central cell of the female gametophyte by repressing target genes before fertilization. After fertilization, it probably also regulates the embryo and endosperm proliferation and anteroposterior organization during seed development. PcG proteins act by forming multiprotein complexes, which are required to maintai [...] (689 aa)
SPLProtein SPOROCYTELESS; Transcriptional regulator of sporocyte development. Acts as an adapter-like transcriptional repressor recruiting TPL/TPR corepressors to inhibit TCP transcription factors. Required for nucellus and embryo sac development. Plays a central role in patterning both the proximal-distal and the adaxial-abaxial axes during ovule development. Involved in establishing the prospective chalaza of the ovule and in controlling the cell number and the length of the funiculus, and is required for the development of the integuments. Required, with BEL1, for cytokinin-induced PIN [...] (314 aa)
CAM1Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
CAM2Calmodulin-2; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
AGL5Agamous-like MADS-box protein AGL5; Probable transcription factor. Interacts genetically with TT16/AGL32 in a partially antagonistic manner during flower development. Is essential for the coordination of cell divisions in ovule, seed coat development and endosperm formation. (246 aa)
CML10Calmodulin-like protein 10; Potential calcium sensor. (191 aa)
AP3Floral homeotic protein APETALA 3; Probable transcription factor involved in the genetic control of flower development. Is required for normal development of petals and stamens in the wild-type flower. Forms a heterodimer with PISTILLATA that is required for autoregulation of both AP3 and PI genes. AP3/PI heterodimer interacts with APETALA1 or SEPALLATA3 to form a ternary complex that could be responsible for the regulation of the genes involved in the flower development. AP3/PI heterodimer activates the expression of NAP. AP3/PI prevents GATA22/GNL and GATA21/GNC expression. (232 aa)
AP2Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...] (432 aa)
CAM7Calmodulin-7; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro. (149 aa)
RAD51DNA repair protein RAD51 homolog 1; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis. (342 aa)
LFYProtein LEAFY; Probable transcription factor that promotes early floral meristem identity in synergy with APETALA1. Is required subsequently for the transition of an inflorescence meristem into a floral meristem, by an immediate upstream regulation of the ABC classes of floral homeotic genes. Activates directly APETALA1, CAULIFLOWER and AGAMOUS, and indirectly APETALA3 and PISTILLATA with the cooperation of UFO. Belongs to the FLO/LFY family. (420 aa)
CAM6Calmodulin-6; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
Q1H557_ARATHMyb domain protein. (141 aa)
AGL11Agamous-like MADS-box protein AGL11; Probable transcription factor (Probable). Is required, together with TT16/AGL32 for the maternal control of endothelium formation, which is essential for female gametophyte development and fertilization, and seed formation. (230 aa)
BEL1Homeobox protein BEL1 homolog; Plays a major role in ovule patterning and in determination of integument identity via its interaction with MADS-box factors. Formation of complex with AG-SEP dimers negatively regulates the carpel identity process and favors the maintenance of ovule identity. BEL1-STM complex maintains the indeterminacy of the inflorescence meristem. Required, with SPL, for cytokinin-induced PIN1 expression in ovules. (611 aa)
GA3OX1Gibberellin 3-beta-dioxygenase 1; Converts the inactive gibberellin (GA) precursors GA9 and GA20 in the bioactives gibberellins GA4 and GA1. Involved in the production of bioactive GA for vegetative growth and development. Belongs to the iron/ascorbate-dependent oxidoreductase family. GA3OX subfamily. (358 aa)
UBQ14Polyubiquitin 14; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasm [...] (305 aa)
ATHB-22Homeobox-leucine zipper protein ATHB-22; Probable transcription factor. (185 aa)
TIR1Protein TRANSPORT INHIBITOR RESPONSE 1; Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism. Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development. Plays a role in ethylene signaling in roots. Confers sensitivity to the virulent bacterial pathogen P.syringae. (594 aa)
MSF3.23SET domain-containing protein. (543 aa)
AHL25AT-hook motif nuclear-localized protein 25; Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity). Binds the DNA sequence GNFEI (GA-negative feedback element I) in the GA3OX1 promoter. Binding to GNFEI sequence is required for GA-negative feedback regulation of GA3OX1. (299 aa)
BT5BTB/POZ and TAZ domain-containing protein 5; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (368 aa)
AIL5AP2-like ethylene-responsive transcription factor AIL5; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Involved in the regulation of floral organs size; Belongs to the AP2/ERF transcription factor family. AP2 subfamily. (558 aa)
WOX8WUSCHEL-related homeobox 8; Probable transcription factor, which may be involved in embryonic patterning. May be required for basal embryo development after fertilization. Acts partially redundantly with STIP in promoting embryonic cell division and proliferation. Promotes cotyledon boundary formation by maintaining the symmetry in CUC genes expression domains ; Belongs to the WUS homeobox family. (325 aa)
WOX2WUSCHEL-related homeobox 2; Probable transcription factor involved in embryonic patterning. Required for apical embryo development after fertilization. Its specific localization to the apical daughter cell of the zygote, while WOX8 is confined to the basal cell, suggests that the asymmetric division of the plant zygote separates determinants of apical and basal cell fates. (260 aa)
ERL2LRR receptor-like serine/threonine-protein kinase ERL2; Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ERL1 and ER. (967 aa)
UBQ10Polyubiquitin 10; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasm [...] (457 aa)
ATML1Homeobox-leucine zipper protein MERISTEM L1; Probable transcription factor involved in cell specification and pattern formation during embryogenesis. Binds to the L1 box DNA sequence 5'-TAAATG[CT]A-3'. Plays a role in maintaining the identity of L1 cells, possibly by interacting with their L1 box or other target- gene promoters. Functionally redundant to PDF2. (762 aa)
PDF2Homeobox-leucine zipper protein PROTODERMAL FACTOR 2; Probable transcription factor that binds to the L1 box DNA sequence 5'-TAAATG[CT]A-3'. Plays a role in maintaining the identity of L1 cells, possibly by interacting with their L1 box or other target- gene promoters. Functionally redundant to ATML1. (743 aa)
GID1CGibberellin receptor GID1C; Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA- induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and stem elongation. Partially redundant with GID1A and GID1B; Belongs to the 'GDXG' l [...] (344 aa)
BT2BTB/POZ and TAZ domain-containing protein 2; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a key role as a component of the TAC1-mediated telomerase activation pathway certainly by targeting a telomerase repressor to degradation. Seems to occupy an integral position in a complex signaling network that perceives, integrates, and responds to multiple, and sometimes competing, signals. Enhances responses to auxin in postgermination and veg [...] (364 aa)
ARF18Auxin response factor 18; Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Could act as transcriptional activator or repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. (602 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
CP1Calcium-binding protein CP1; Binds calcium in vitro. (160 aa)
VDDB3 domain-containing protein At5g18000. (307 aa)
KAN4Probable transcription factor KAN4; Probable transcription factor that regulates carpel integuments formation. Required for the specification of polarity in the ovule inner integument. Modulates the content of flavonols and proanthocyanidin in seeds. (276 aa)
MRG7.5B3 domain-containing protein At5g18090. (301 aa)
AFB3Protein AUXIN SIGNALING F-BOX 3; Confers sensitivity to the virulent bacterial pathogen P.syringae (By similarity). Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin- regulated transcription. Involved in embryogenesis regulation by auxin. (577 aa)
ATHB-53Homeobox-leucine zipper protein ATHB-53; Probable transcription factor that may play a regulatory role in auxin/cytokinin signaling during root development. Belongs to the HD-ZIP homeobox family. Class I subfamily. (228 aa)
ATHB-51Putative homeobox-leucine zipper protein ATHB-51; Putative transcription factor. (235 aa)
NGA2B3 domain-containing transcription factor NGA2; Regulates lateral organ growth. Functionally redundant with NGA1, NGA3 and NGA4. (299 aa)
AHL15AT-hook motif nuclear-localized protein 15; Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity). Binds the DNA sequence GNFEI (GA-negative feedback element I) in the GA3OX1 promoter. Negatively regulates plant innate immunity (PTI) to pathogens through the down-regulation of the PAMP-triggered FRK1 expression. (310 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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