STRINGSTRING
UBQ13 UBQ13 BUB1 BUB1 MCM6 MCM6 BUBR1 BUBR1 SCC3 SCC3 UBQ4 UBQ4 UBQ11 UBQ11 CDKA-1 CDKA-1 CYCB1-1 CYCB1-1 MCM7 MCM7 ACT7 ACT7 MCM4 MCM4 PCNA2 PCNA2 PARP1 PARP1 F15I1.1 F15I1.1 SYN1 SYN1 PCNA PCNA MAD2 MAD2 SMC5 SMC5 E2FB E2FB DPA DPA E2FA E2FA SMC4 SMC4 UBQ9 UBQ9 SCC4 SCC4 RFC5 RFC5 RFC2 RFC2 F19K16.15 F19K16.15 ACT2 ACT2 MYB3R4 MYB3R4 RFC4 RFC4 SYN4 SYN4 RFC3 RFC3 WEE1 WEE1 PRE6 PRE6 hus1 hus1 SMC3 SMC3 ETG1 ETG1 UBQ14 UBQ14 UBQ8 UBQ8 ORC2 ORC2 A0A1I9LT08 A0A1I9LT08 SCC2 SCC2 CTF7 CTF7 ESFL3 ESFL3 CTF18 CTF18
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
UBQ13Ubiquitin 13. (319 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1; Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C). Necessary for ensuring proper chromosome segregation. Can regulate chromosome segregation in a kinetochore-independent manner. The BUB1- BUB3 complex plays a role in the inhibition of APC/C when spindle- assemb [...] (525 aa)
MCM6DNA replication licensing factor MCM6; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. (831 aa)
BUBR1Mitotic spindle checkpoint protein BUBR1; Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions may be to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C (By similarity). (395 aa)
SCC3Sister-chromatid cohesion protein 3; Essential component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Required for centromere cohesion maintenance at anaphase I and for the monopolar orientation of the kinetochores during both male and [...] (1098 aa)
UBQ4Polyubiquitin 4; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmi [...] (382 aa)
UBQ11Polyubiquitin 11; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasm [...] (229 aa)
CDKA-1Cyclin-dependent kinase A-1; Involved in the control of the cell cycle. Essential for both G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis. Required to trigger guard mother cells (GMC) symmetric divisions at the late stage of stomatal development, probably via the regulation of G1 to S transition in the cell cycle. Required for the function of SPCH in entering the stomatal lineage. Promotes divisions in the guard cells (GCs) after the gu [...] (294 aa)
CYCB1-1Cyclin-B1-1. (428 aa)
MCM7DNA replication licensing factor MCM7; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells (By similarity). Required for megagametophyte and embryo development. (716 aa)
ACT7Actin-7; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation. (377 aa)
MCM4DNA replication licensing factor MCM4; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. (847 aa)
PCNA2Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity). May be involved in UV resistance. Belongs to the PCNA family. (264 aa)
PARP1Poly [ADP-ribose] polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). (983 aa)
F15I1.1Ubiquitin-like superfamily protein. (158 aa)
SYN1Sister chromatid cohesion 1 protein 1; Involved in chromosome condensation, pairing and segregation during meiosis. Responsible for cohesion between replicated sister chromatids. (627 aa)
PCNAProliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
MAD2Mitotic spindle checkpoint protein MAD2; Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. It inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. (209 aa)
SMC5Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids; Belongs to the SMC family. SMC5 subfamily. (1053 aa)
E2FBTranscription factor E2FB; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. (469 aa)
DPATranscription factor-like protein DPA; Involved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specific genes; Belongs to the E2F/DP family. (292 aa)
E2FATranscription factor E2FA; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. Belongs to the E2F/DP family. (485 aa)
SMC4Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis; Belongs to the SMC family. SMC4 subfamily. (1241 aa)
UBQ9Ubiquitin-related 1; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endopl [...] (322 aa)
SCC4Sister chromatid cohesion protein SCC4; Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes. (726 aa)
RFC5Replication factor C subunit 5; Functions in cell replication and proliferation. May be involved in chromatin assembly and remodeling. Plays a role in the negative control of pathogenesis-related gene expression and systemic acquired resistance (SAR). (369 aa)
RFC2Replication factor C subunit 2; May be involved in DNA replication and thus regulate cell proliferation. (333 aa)
F19K16.15RAD3-like DNA-binding helicase protein. (882 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
MYB3R4Transcription factor MYB3R-4; Transcription factor that binds 5'-AACGG-3' motifs in gene promoters. Involved in the regulation of cytokinesis, probably via the activation of several G2/M phase-specific genes transcription (e.g. KNOLLE). Required for the maintenance of diploidy. (961 aa)
RFC4Replication factor C subunit 4; May be involved in DNA replication and thus regulate cell proliferation; Belongs to the activator 1 small subunits family. (339 aa)
SYN4Sister chromatid cohesion 1 protein 4; Involved in sister chromatid and centromere cohesion during mitosis. (1031 aa)
RFC3Replication factor C subunit 3; May be involved in DNA replication and thus regulate cell proliferation. (354 aa)
WEE1Wee1-like protein kinase; Cell cycle regulatory kinase that is not rate-limiting for cycle progression under normal growth conditions. Transcriptionally activated upon DNA stress or damage in an ATR- or ATM-dependent manner. Once activated, inhibits plant growth by arresting dividing cells in the G2 phase before proceeding into mitosis. Down-regulates CDKA-1 and CDKD-2 by tyrosine phosphorylation. May target principally CDKA-1. (500 aa)
PRE6Transcription factor PRE6; Atypical and probable non DNA-binding bHLH transcription factor that regulates light-mediated responses in day light conditions by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance. Forms non-functional heterodimers with HFR1, causing liberation and activation of PIF4 from the transcriptionally inactive HFR1-PIF4 complex. (94 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (319 aa)
SMC3Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity). Essential protein plant viabili [...] (1204 aa)
ETG1Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin. Required for sister chromatid cohesion. Belongs to the MCMBP family. (589 aa)
UBQ14Polyubiquitin 14; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasm [...] (305 aa)
UBQ8Ubiquitin-related 1; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endopl [...] (631 aa)
ORC2Origin of replication complex subunit 2; Essential protein. Component of the origin recognition complex (ORC) that binds origins of replication. DNA- binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (363 aa)
A0A1I9LT08Shugoshin. (274 aa)
SCC2Sister chromatid cohesion protein SCC2; Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion during meiosis and mitosis. Forms a complex with SCC4, which is required for the association of the cohesin complex with chromosomes. Plays a structural role in chromatin, especially in centromere organization, chromosomal axis formation, and distribution of the cohesin subunit SCC3 on chromosomes. (1846 aa)
CTF7Protein CHROMOSOME TRANSMISSION FIDELITY 7; Acetyltransferase required for the establishment of sister chromatid cohesion. Involved in preservation of genome integrity and meiosis. Required for DNA repair and for the regulation of chromosome segregation during mitotic cell division. Knock-down mutants are extremely dwarf. (345 aa)
ESFL3EMBRYO SURROUNDING FACTOR 1-like protein 3. (88 aa)
CTF18P-loop containing nucleoside triphosphate hydrolases superfamily protein. (943 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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