STRINGSTRING
A0A1I9LSE2 A0A1I9LSE2 CLE2 CLE2 CLV2 CLV2 RHL1 RHL1 CLE1 CLE1 CLE14 CLE14 CLE20 CLE20 WOX5 WOX5 CLE19 CLE19 RLK RLK CLE9 CLE9 CLE40 CLE40 CRN CRN WUS WUS CLV1 CLV1 CLV3 CLV3 ABCG33 ABCG33
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A1I9LSE2Cyclin B1. (100 aa)
CLE2CLAVATA3/ESR (CLE)-related protein 2; Extracellular signal peptide that regulates cell fate. May act with CLV1 as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions. (75 aa)
CLV2Receptor-like protein CLAVATA2; Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance. Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers. In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding structure (syncytium) development and ultimately successful [...] (720 aa)
RHL1DNA-binding protein RHL1; Component of the DNA topoisomerase VI complex involved in chromatin organization and progression of endoreduplication cycles. Binds to DNA. Required for endoreduplication beyond 8C. (355 aa)
CLE1CLAVATA3/ESR (CLE)-related protein 1; Extracellular signal peptide that regulates cell fate. Belongs to the CLV3/ESR signal peptide family. (74 aa)
CLE14CLAVATA3/ESR (CLE)-related protein 14; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Acts as an elicitor of the root meristem differentiation through the CLV2/CRN complex signaling pathway. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem. (80 aa)
CLE20CLAVATA3/ESR (CLE)-related protein 20; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem ; Belongs to the CLV3/ESR signal peptide family. (83 aa)
WOX5WUSCHEL-related homeobox 5; Transcription factor, which may be involved in the specification and maintenance of the stem cells (QC cells) in the root apical meristem (RAM). (182 aa)
CLE19CLAVATA3/ESR (CLE)-related protein 19; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (74 aa)
RLKLeucine-rich repeat receptor-like protein kinase. (751 aa)
CLE9CLAVATA3/ESR (CLE)-related protein 9; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (120 aa)
CLE40CLAVATA3/ESR (CLE)-related protein 40; Extracellular signal peptide secreted by differentiated root cells that regulates root cell fate. Acts with ACR4 as a ligand- receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Promotes cell differentiation in the distal root meristem in a dose-dependent manner, especially the transition from columella stem cells (CSC) daughters into columella cells (CCs). Induces ACR4 expression in root quiescent center (QC). Involved in WUX5 QC-specific expression pattern [...] (80 aa)
CRNInactive leucine-rich repeat receptor-like protein kinase CORYNE; Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that acts as a extracellular signals regulating meristems maintenance. Modulates root, shoot and flower apical meristems maintenance and floral organ development regulation, probably via CLAVATA (CLV)-like pathways involving at least CLV3 and CLE19. In complex with CLV2, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding struc [...] (401 aa)
WUSProtein WUSCHEL; Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expr [...] (292 aa)
CLV1Receptor protein kinase CLAVATA1; Involved in the detection of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3p as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (980 aa)
CLV3Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family. (96 aa)
ABCG33ABC transporter G family member 33; May be a general defense protein; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1413 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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