STRINGSTRING
SLAC1 SLAC1 ABI1 ABI1 PP2CA PP2CA ABI3 ABI3 LEC2 LEC2 MAE1 MAE1 CPK4 CPK4 CPK11 CPK11 MPK1 MPK1 MPK6 MPK6 SRK2D SRK2D CPK3 CPK3 ABCG25 ABCG25 CIPK1 CIPK1 SRK2E SRK2E BZIP8 BZIP8 HAB1 HAB1 SAG113 SAG113 AHG1 AHG1 HAB2 HAB2 AIP1 AIP1 FUS3 FUS3 CPK23 CPK23 ABF4 ABF4 ABF1 ABF1 ABCG40 ABCG40 ABI5 ABI5 HAI3 HAI3 ABI4 ABI4 ABI2 ABI2 RBOHF RBOHF ALMT12 ALMT12 SRK2J SRK2J TOPP1 TOPP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLAC1Guard cell S-type anion channel SLAC1; Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis. Cl(-) efflux through SLAC1 causes membrane depolarization, which activates outward- rectifying K1 channels, leading to KCl and water efflux to reduce turgor further and cause stomatal closure, that reduces water loss and promotes leaf turgor. Essential for stomatal closure in response to CO(2), abscisic acid (ABA), ozone O(3), light/dark transitions, humidity change, calcium ions, hydrogen peroxide H(2)O(2), reactive oxygen species (ROS), and nit [...] (556 aa)
ABI1Protein phosphatase 2C 56; Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), drought-induced resistance and rhizogenesis, response to glucose, high light stress, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as the actin reorganization in guard cells in response to ABA. Involved in the resistance to the bacterial pathogen Pseudomonas syrin [...] (434 aa)
PP2CAProtein phosphatase 2C 37; Major negative regulator of abscisic acid (ABA) responses during seed germination and cold acclimation. Confers insensitivity to ABA. Modulates negatively the AKT2/3 activity, which mediates K(+) transport and membrane polarization during stress situations, probably by dephosphorylation. Prevents stomata closure by inactivating the S- type anion efflux channel SLAC1 and its activator SRK2E. Represses KIN10 activity by the specific dephosphorylation of its T-loop Thr-198, leading to a poststress inactivation of SnRK1 signaling. (399 aa)
ABI3B3 domain-containing transcription factor ABI3; Participates in abscisic acid-regulated gene expression during seed development. Regulates the transcription of SGR1 and SGR2 that are involved in leaf and embryo degreening. (720 aa)
LEC2B3 domain-containing transcription factor LEC2; Transcription regulator that plays a central role in embryo development. Required for the maintenance of suspensor morphology, specification of cotyledon identity, progression through the maturation phase and suppression of premature germination. Ectopic expression is sufficient to promote somatic embryogenesis. (363 aa)
MAE1Putative defensin-like protein 224. (106 aa)
CPK4Calcium-dependent protein kinase 4; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions as regulator of the calcium- mediated abscisic acid (ABA) signaling pathway. Phosphorylates ABA- responsive transcription factors ABF1 and ABF4 in vitro. Phosphorylates the nuclear zinc finger Di19 in vitro. (501 aa)
CPK11Calcium-dependent protein kinase 11; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions as regulator of the calcium- mediated abscisic acid (ABA) signaling pathway. Phosphorylates ABA- responsive transcription factors ABF1 and ABF4 in vitro. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (495 aa)
MPK1Mitogen-activated protein kinase 1. (370 aa)
MPK6Mitogen-activated protein kinase 6; Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Phosphorylates 1-aminocyclopropane-1- carboxylic acid synthases (ACS2 and ACS6) and may be involved in the regulati [...] (395 aa)
SRK2DSerine/threonine-protein kinase SRK2D; Together with SRK2I, key component and activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as seed germination, Pro accumulation, root growth inhibition, dormancy and seedling growth, and, to a lesser extent, stomatal closure; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (362 aa)
CPK3Calcium-dependent protein kinase 3; May play a role in signal transduction pathways that involve calcium as a second messenger. Functions in abscisic acid (ABA) regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure. (529 aa)
ABCG25ABC transporter G family member 25. (662 aa)
CIPK1CBL-interacting serine/threonine-protein kinase 1; CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (444 aa)
SRK2ESerine/threonine-protein kinase SRK2E; Activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomata closure in response to drought, darkness, high CO(2), plant pathogens, or decreases in atmospheric relative humidity (RH). Involved in the resistance to drought by avoiding water loss. Required for the stomata closure mediated by pathogen-associated molecular pattern (PAMPs) (e.g. flg22 and LPS) of pathogenic bacteria such as P.syringae pv. tomato (Pst) and E.coli O157:H7. As a plant defense process, stomata are closed transiently in order [...] (362 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
HAB1Protein phosphatase 2C 16; Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought. Belongs to the PP2C family. (511 aa)
SAG113Probable protein phosphatase 2C 78; Acts as negative regulator of abscisic acid (ABA) signaling for stomatal closure in leaves, and controls water loss during leaf senescence. Activated by the NAC029/NAP transcription factor during ABA signaling in senescing leaves. Functions as negative regulator of osmotic stress and ABA signaling. Acts as negative regulator of response to drought. Belongs to the PP2C family. (413 aa)
AHG1Probable protein phosphatase 2C 75; Negative regulator of abscisic acid (ABA) responses during seed germination; Belongs to the PP2C family. (416 aa)
HAB2Protein phosphatase 2C 7; Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. (511 aa)
AIP1Protein phosphatase 2C 3; Involved in the negative regulation of the K(+) potassium channel AKT1 by its dephosphorylation, antagonistically to CIPK proteins (e.g. CIPK23). Functions as positive regulator of abscisic acid-mediated cell signaling during seedling growth. Involved in the regulation of seed dormancy. Acts as negative regulator of seed dormancy by inhibiting abscisic signaling and subsequently activating gibberellic acid signaling ; Belongs to the PP2C family. (442 aa)
FUS3B3 domain-containing transcription factor FUS3; Transcription regulator involved in gene regulation during late embryogenesis. Its expression to the epidermis is sufficient to control foliar organ identity by regulating positively the synthesis abscisic acid (ABA) and negatively gibberellin production. Negatively regulates TTG1 in the embryo. Positively regulates the abundance of the ABI3 protein in the seed. Cooperates with KIN10 to regulate developmental phase transitions and lateral organ development and act both as positive regulators of abscisic acid (ABA) signaling during germination. (313 aa)
CPK23Calcium-dependent protein kinase 23; May play a role in signal transduction pathways that involve calcium as a second messenger. Could act as a calcium sensor involved in drought- and salt stress-induced calcium signaling cascades. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. (520 aa)
ABF4ABSCISIC ACID-INSENSITIVE 5-like protein 7; Functions as transcriptional activator in the ABA-inducible expression of rd29B. Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter. (431 aa)
ABF1ABSCISIC ACID-INSENSITIVE 5-like protein 4; Binds to the ABA-responsive element (ABRE). Could participate in abscisic acid-regulated gene expression; Belongs to the bZIP family. ABI5 subfamily. (392 aa)
ABCG40ABC transporter G family member 40; May be a general defense protein (By similarity). Functions as a pump to exclude Pb(2+) ions and/or Pb(2+)-containing toxic compounds from the cytoplasm. Contributes to Pb(2+) ions resistance. Confers some resistance to the terpene sclareol. (1423 aa)
ABI5Protein ABSCISIC ACID-INSENSITIVE 5; Participates in ABA-regulated gene expression during seed development and subsequent vegetative stage by acting as the major mediator of ABA repression of growth. Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 and Em6 genes promoters. Can also trans- activate its own promoter, suggesting that it is autoregulated. Plays a role in sugar-mediated senescence. Belongs to the bZIP family. ABI5 subfamily. (442 aa)
HAI3Probable protein phosphatase 2C 24. (362 aa)
ABI4Ethylene-responsive transcription factor ABI4; Transcription regulator that probably binds to the GCC-box pathogenesis-related promoter element. Binds also to the S-box (5'- CACTTCCA-3') photosynthesis-associated nuclear genes-related (PhANGs- related) promoter element, and thus acts as a transcription inhibitor. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. May have a function in the deetiolation process. Confers sensitivity to abscisic acid (ABA), and regulates the ABA signaling pathway during seed germinatio [...] (328 aa)
ABI2Protein phosphatase 2C 77; Repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), high light stress, response to glucose, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as H(2)O(2) and oxidative burst in response to ABA and dehydration. Represses GHR1 and, to some extent, SRK2E/OST1, kinases involved in the regulation of SLAC1-dependent stomatal closure. Controls [...] (423 aa)
RBOHFRespiratory burst oxidase homolog protein F; Calcium-dependent NADPH oxidase that generates superoxide. Generates reactive oxygen species (ROS) during incompatible interactions with pathogens and is important in the regulation of the hypersensitive response (HR). Involved in abscisic acid-induced stomatal closing and in UV-B and abscisic acid ROS-dependent signaling. Belongs to the RBOH (TC 5.B.1.3) family. (944 aa)
ALMT12Aluminum-activated malate transporter 12; Malate-sensitive anion transporter permeable to chloride, nitrate, sulfate and malate. Involved in dark-, CO(2)-, abscisic acid- and water-deficient-induced stomatal closure. Belongs to the R- type anion channels. (560 aa)
SRK2JSerine/threonine-protein kinase SRK2J; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (339 aa)
TOPP1Serine/threonine-protein phosphatase PP1 isozyme 1; Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro. Acts as negative regulator of abscisic acid (ABA) signaling. In vitro, can dephosphorylate and inhibit the kinase activity of SRK2E/SNRK2.6, an activator of ABA signaling. (318 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.