STRINGSTRING
F1C9.19 F1C9.19 SAHH1 SAHH1 H2B H2B DCL4 DCL4 SAMDC4 SAMDC4 DCL2 DCL2 SDC SDC DRB5 DRB5 DBR4 DBR4 SAMDC1 SAMDC1 DCL DCL DRB3 DRB3 SAMDC3 SAMDC3 DCL3 DCL3 ADK2-2 ADK2-2 SAMDC2 SAMDC2 ADK1-2 ADK1-2 DRB2 DRB2 AL2 AL2 OTP51 OTP51 AGO4 AGO4
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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textmining
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F1C9.19Transferase. (666 aa)
SAHH1Adenosylhomocysteinase 1; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Required for DNA methylation-dependent gene silencing. (485 aa)
H2BHistone H2B.6; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (150 aa)
DCL4Dicer-like protein 4; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Functions in the biogenesis of trans-acting small interfering RNAs (ta-siRNAs, derived from the TAS1, TAS2 or TAS3 endogenous transcripts) by cleaving small dsRNAs into 21- 24 nucleotide ta-siRNAs. Functions with the dsRNA-binding protein DRB4 in ta-siRNAs processing. Acts in the RDR6/SGS3/DCL4/AGO7 ta-siRNA pathway involved in leaf developmental timing. Plays a role in transitive silencing of transgenes by processing secondary siRNAs. This pathway, which requires DCL2 a [...] (1702 aa)
SAMDC4S-adenosylmethionine decarboxylase 1 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development. (347 aa)
DCL2Endoribonuclease Dicer homolog 2; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Involved in the processing of natural small interfering RNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving small dsRNAs into 24 nucleotide nat- siRNAs. Plays an essential role in transitive silencing of transgenes by processing secondary siRNAs. This pathway, which requires DCL4 and RDR6, amplifies silencing by using the target RNA as substrate to generate secondary siRNAs, providing an efficient mechanism for long- distance silenci [...] (1388 aa)
SDCF-box protein At2g17690; Involved in heat stress response. Contributes to recovery from heat stress. (421 aa)
DRB5Double-stranded RNA-binding protein 5; Binds double-stranded RNA. May be involved in RNA-mediated silencing. (393 aa)
DBR4Double-stranded RNA-binding protein 4; Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the trans- acting small interfering RNAs (ta-siRNAs) biogenesis by binding and assisting DICER-LIKE 4 (DCL4). Required for DCL4 activity. Required for the 21 nucleotide ta-siRNAs production of the TAS3 transcript in leaves but not in flowers. Plays an important role in silencing RNA of both DNA and RNA viruses. Involved with argonaute 7 (AGO7) and RDR6 in turnip crinkle virus (TCV) silencing. May not be directly involved in viral s [...] (355 aa)
SAMDC1S-adenosylmethionine decarboxylase 1 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development; Belongs to the eukaryotic AdoMetDC family. (366 aa)
DCLProtein DCL homolog, chloroplastic; Required for normal plastid function and plant development. Required for correct plastid ribosome assembly. Required for processing and maturation of 4.5S rRNA. (219 aa)
DRB3Double-stranded RNA-binding protein 3; Binds double-stranded RNA. (359 aa)
SAMDC3S-adenosylmethionine decarboxylase 1 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development. (349 aa)
DCL3Endoribonuclease Dicer homolog 3; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Involved in the processing of repeat-associated small interfering RNAs (ra-siRNAs, derived from heterochromatin and DNA repeats such as transposons) by cleaving small dsRNAs into 24 nucleotide ra-siRNAs. Plays a role in antiviral RNA silencing. Involved in the production of viral siRNAs derived from the cabbage leaf curl virus (CaLCuV) and tobacco rattle virus (TRV). Targeted by the viral silencing suppressor (VSR) protein 2b of the cucumber mosaic virus (CMV [...] (1580 aa)
ADK2-2Adenosine kinase 2; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Essential to sustain methyl recycling; Belongs to the carbohydrate kinase PfkB family. (345 aa)
SAMDC2S-adenosylmethionine decarboxylase 2 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development; Belongs to the eukaryotic AdoMetDC family. (362 aa)
ADK1-2Adenosine kinase 1; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Essential to sustain methyl recycling. (344 aa)
DRB2Double-stranded RNA-binding protein 2; Binds double-stranded RNA. May be involved in RNA-mediated silencing. (434 aa)
AL2PHD finger protein ALFIN-LIKE 2, N-terminally processed; Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes; Belongs to the Alfin family. (246 aa)
OTP51Pentatricopeptide repeat-containing protein At2g15820, chloroplastic; Promotes the splicing of group II introns in chloroplasts. Required for the splicing of intron 2 of plastid ycf3 transcripts, a factor required for the assembly of photosystem I (PSI). Involved in the splicing of several other group-IIa introns. May be involved in the splicing of precursor forms of trnL, trnG, trnI, and trnA. Required for the assembly of PSI and PSII. (849 aa)
AGO4Protein argonaute 4; Together with RDM3, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci. Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats. Forms a AGO4/NRPE1/siRNA complex in cajal body, facilitating its function in RNA-directed gene silencing of target loci. Required for CpNpG and asymmetric DNA methylation as well as histone H3 'Lys-9' methylation (H3K9me) at SUP and SN1 loci. May be [...] (924 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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