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F4JFF2_ARATH F4JFF2_ARATH F23H11.11 F23H11.11 F23H11.12 F23H11.12 CDA8 CDA8 CDA7 CDA7 CDA6 CDA6 CUL2 CUL2 CDA3 CDA3 CDA5 CDA5 MNC17.5 MNC17.5 CUL1 CUL1 RBX1A RBX1A UEV1A UEV1A ALPHA-ADR ALPHA-ADR SDE3 SDE3 UBC13 UBC13 F1I21.19 F1I21.19 CDA1 CDA1 CDA2 CDA2 SR34 SR34
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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F4JFF2_ARATHNucleotidyltransferase. (1303 aa)
F23H11.11Putative cullin-like protein 2; Belongs to the cullin family. (374 aa)
F23H11.12Cullin-like protein 3; Belongs to the cullin family. (255 aa)
CDA8Cytidine deaminase 8; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (293 aa)
CDA7Cytidine deaminase 7; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (307 aa)
CDA6Cytidine deaminase 6; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (293 aa)
CUL2Cullin-2; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Involved in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). (742 aa)
CDA3Cytidine deaminase 3; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (223 aa)
CDA5Cytidine deaminase 5; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (346 aa)
MNC17.5BTB/POZ domain-containing protein; Belongs to the SKP1 family. (96 aa)
CUL1Cullin-1; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Regulator of mitotic processes which plays a role during gametogenesis and embryogenesis. Together with SKP1, RBX1 and a F-box protein, it forms a SCF complex. The functional specificity of this complex depends of the type of F-box protein. SCF(UFO) is implicated in floral organ development. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1/ZTL), SCF(ADO2/LKP2), SCF(A [...] (738 aa)
RBX1ARING-box protein 1a; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL1. Belongs to the RING-box family. (118 aa)
UEV1AUbiquitin-conjugating enzyme E2 variant 1A; Has no ubiquitin ligase activity on its own. The heterodimer with UBC catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. May play a role in the control of progress through the cell cycle and differentiation. Probably not involved in the error-free DNA repair. (158 aa)
ALPHA-ADRAP-2 complex subunit alpha-1; Subunit of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The complex binds polyphosphoinositides (By similarity). (1012 aa)
SDE3Probable RNA helicase SDE3; Probable RNA helicase required for post-transcriptional gene silencing (PTGS), a process that provides protection in plants against virus infection and can suppress expression of transgenes. Plays a central role in RNA interference (RNAi) process, a process that mediates mRNA destruction of translational repression. Required for the assembly of the RISC complex, a complex required for target RNA destruction or repression. May be required in the RISC assembly to unwind miRNAs, in the production of single-stranded miRNA from the double-stranded miRNA, a key st [...] (1002 aa)
UBC13Ubiquitin-conjugating enzyme E2 13; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Involved in the formation of multiubiquitin chains. Signal the protein for selective degradation. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
F1I21.19Putative cullin-like protein 1; Belongs to the cullin family. (721 aa)
CDA1Cytidine deaminase 1; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Functions as a conventional cytidine deaminase. Has no affinity for RNA and is not involved in RNA- editing by C-to-U deamination. (301 aa)
CDA2Cytidine deaminase 2; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (337 aa)
SR34Serine/arginine-rich-splicing factor SR34; General splicing factor. Can promote splice site selection in vitro presumably by antagonizing the effects of the A1 heterogeneous nuclear ribonucleoprotein. May have an essential function during early plant development; Belongs to the splicing factor SR family. SR subfamily. (303 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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