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ATI1 ATI1 CHLG CHLG RPM1 RPM1 ATG8A ATG8A ATG9 ATG9 WRKY33 WRKY33 ATG8H ATG8H ATG8E ATG8E ATI2 ATI2 ATG8F ATG8F ATG10 ATG10 ATG18A ATG18A ATG7 ATG7 ACT2 ACT2 ATG5 ATG5 ATG8I ATG8I ATG8G ATG8G ATG6 ATG6 NBR1 NBR1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ATI1ATG8-interacting protein 1; Involved in a special stress-induced plastid-to-vacuole protein trafficking pathway. Interacts with ATG8F in plastid bodies to subsequently enable their delivery to the vacuole by an autophagic pathway. Interacts with the plastid proteins APE1 and PSBS/NPQ4 and may recruit them as cargo into plastid bodies that may be recognized by the autophagy machinery for degradation in the vacuole. Involved in the alleviation of damage caused by salt stress during plant development, probably through its involvement in plastid-to-vacuole and ER-to- vacuole trafficking. P [...] (256 aa)
CHLGChlorophyll synthase, chloroplastic; Involved in one of the last steps of the biosynthesis of chlorophyll a. Catalyzes the esterification of chlorophillide a or b with a preference for geranylgeranyldiphosphate (GGPP) rather than for phytyldiphosphate (PhyPP). (387 aa)
RPM1Disease resistance protein RPM1; Disease resistance (R) protein that specifically recognizes the AvrRpm1 type III effector avirulence protein from Pseudomonas syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Acts via its interaction with RIN4, and probably triggers the plant resistance when RIN4 is phosphorylated by AvrRpm1. It is then degraded at the onset of th [...] (926 aa)
ATG8AAutophagy-related protein 8a; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
ATG9Autophagy-related protein 9; Required for autophagy that plays an essential role in plant nutrient recycling. Contributes to efficient autophagic flux, especially in early autophagic process prior to the fusion of the autophagosome with the vacuole. Belongs to the ATG9 family. (866 aa)
WRKY33Probable WRKY transcription factor 33; Transcription factor. Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Involved in defense responses. Required for resistance to the necrotrophic fungal pathogen B.cinerea. Regulates the antagonistic relationship between defense pathways mediating responses to the bacterial pathogen P. syringae and the necrotrophic pathogen B.cinerea. Required for the phytoalexin camalexin synthesis following infection with B.cinerea. Acts as positive regulator of the camalexin biosynthetic ge [...] (519 aa)
ATG8HAutophagy-related protein 8h; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton; Belongs to the ATG8 family. (119 aa)
ATG8EAutophagy-related protein 8e; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
ATI2ATG8-interacting protein 2; May be involved in salt stress-induced vesicle-to-vacuole trafficking pathway. Through its interaction with ATG8F, may enable delivery of the vesicle bodies to the vacuole by an autophagic pathway (Probable). Plays a role in seed germination in response to exogenous abscisic acid (ABA) treatment. (266 aa)
ATG8FAutophagy-related protein 8f; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (121 aa)
ATG10Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] (225 aa)
ATG18AAutophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. (425 aa)
ATG7Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing. (697 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
ATG5Autophagy protein 5; Required for autophagy. Conjugation to ATG12 is essential for plant nutrient recycling. Involved in a negative feedback loop that modulates NPR1-dependent salicylic acid (SA) signaling and limits senescence and immunity-related programmed cell death (PCD) in plants. Involved in complete proteolysis of chloroplast stroma proteins in senescent leaves. Involved in the degradation of damaged peroxisomes. Belongs to the ATG5 family. (337 aa)
ATG8IAutophagy-related protein 8i; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (115 aa)
ATG8GAutophagy-related protein 8g; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (121 aa)
ATG6Beclin-1-like protein; Required for normal plant development. Required for pollen germination. Required for autophagic activity. Required to limit the pathogen-associated cell death response. May be involved in vacuolar protein sorting. Binds to microtubules. May facilitate efficient recruitment of other ATG proteins to assemble scaffolds for autophagosome biogenesis. Belongs to the beclin family. (517 aa)
NBR1Protein NBR1 homolog; Autophagic substrate degraded in the vacuole by non-selective autophagy. Requires ATG8 protein expression to be recognized as an autophagic substrate. Acts probably as a receptor for autophagosomal degradation of ubiquitinated proteins. Targets ubiquitinated protein aggregates derived from denatured or damaged non- native proteins generated under stress conditions. Functions additively with the E3 ubiquitin-protein ligase CHIP for autophagosomal degradation of proteotoxic aggregates formed under stress conditions. (704 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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