STRINGSTRING
PGI1 PGI1 AXS1 AXS1 HKL3 HKL3 RHM1 RHM1 F9F13.110 F9F13.110 GAE5 GAE5 T28P16.12 T28P16.12 AXS2 AXS2 PGM2 PGM2 PGMP PGMP MUR4 MUR4 GBSS1 GBSS1 PMI1-2 PMI1-2 T22E16.250 T22E16.250 T16L24.30 T16L24.30 SUS3 SUS3 GAE1 GAE1 SUS4 SUS4 NRS/ER NRS/ER HKL1 HKL1 GAE2 GAE2 T21E18.7 T21E18.7 T21E18.8 T21E18.8 GAE6 GAE6 PMI2-2 PMI2-2 HXK3 HXK3 GAPC2 GAPC2 SUS6 SUS6 MIO24.3 MIO24.3 DUR DUR GT20 GT20 XXT5 XXT5 F9E10.24 F9E10.24 F28G11.11 F28G11.11 F17I23.90 F17I23.90 A0A1P8ARU2 A0A1P8ARU2 F28I8.31 F28I8.31 SUS5 SUS5 GAE4 GAE4 CYT1 CYT1 PGM3 PGM3 MEE25 MEE25 GAE3 GAE3 F24G24.60 F24G24.60 GAPC1 GAPC1 PGIC PGIC SUS1 SUS1 HXK2 HXK2 SUS2 SUS2 HXK1 HXK1 ATHXK4 ATHXK4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PGI1Glucose-6-phosphate isomerase 1, chloroplastic; Promotes the synthesis of starch in leaves. (613 aa)
AXS1UDP-D-apiose/UDP-D-xylose synthase 1; Catalyzes the conversion of UDP-D-glucuronate to a mixture of UDP-D-apiose and UDP-D-xylose. D-Apiose (3-C-hydroxymethyl-d-erythrose) is the only plant cell wall monosaccharide with a branched carbon skeleton and is found in rhamnogalacturonan II (RG-II), apiogalacturonan, and several apioglycosides. (389 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
RHM1UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose 4-keto-reductase; Trifunctional enzyme involved in UDP-beta-L-rhamnose biosynthesis, a precursor of the primary cell wall components rhamnogalacturonan I (RG-I) and rhamnogalacturonan II (RG-II). Plays a major role in supplying UDP-rhamnose for flavonol biosynthesis. Catalyzes the dehydration of UDP-glucose to form UDP-4-dehydro-6-deoxy- D-glucose followed by the epimerization of the C3' and C5' positions of UDP-4-dehydro-6-deoxy-D-glucose to form UDP-4-keto-beta-L-rhamnose and the reduction of UDP-4-keto-beta-L-rhamnose [...] (669 aa)
F9F13.110Probable UDP-arabinose 4-epimerase 3. (411 aa)
GAE5UDP-glucuronate 4-epimerase 5; Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components. (436 aa)
T28P16.12Probable fructokinase-1; May play an important role in maintaining the flux of carbon towards starch formation. (325 aa)
AXS2UDP-D-apiose/UDP-D-xylose synthase 2; Catalyzes the conversion of UDP-D-glucuronate to a mixture of UDP-D-apiose and UDP-D-xylose. D-Apiose (3-C-hydroxymethyl-d-erythrose) is the only plant cell wall monosaccharide with a branched carbon skeleton and is found in rhamnogalacturonan II (RG-II), apiogalacturonan, and several apioglycosides (By similarity). Belongs to the NAD(P)-dependent epimerase/dehydratase family. (389 aa)
PGM2Probable phosphoglucomutase, cytoplasmic 2; This enzyme participates in both the breakdown and synthesis of glucose. (585 aa)
PGMPPhosphoglucomutase, chloroplastic; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (623 aa)
MUR4UDP-arabinose 4-epimerase 1; Acts as a UDP-D-xylose 4-epimerase but lacks both UDP-D- glucose and UDP-D-glucuronic acid 4-epimerase activities in vitro. Belongs to the NAD(P)-dependent epimerase/dehydratase family. (419 aa)
GBSS1Granule-bound starch synthase 1, chloroplastic/amyloplastic; Required for the synthesis of amylose. Destroyed as it is released from the starch granules during the night. The circadian expression is controlled by CCA1 and LHY transcription factors. (610 aa)
PMI1-2Mannose-6-phosphate isomerase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. Involved in the ascorbic acid (AsA) biosynthesis. Required during the endosperm development. (432 aa)
T22E16.250Probable mannose-1-phosphate guanylyltransferase 2; Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. (364 aa)
T16L24.30Probable fructokinase-4; May play an important role in maintaining the flux of carbon towards starch formation. (326 aa)
SUS3Sucrose synthase 3; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and direct carbon towards starch synthesis in developing seeds. (809 aa)
GAE1UDP-glucuronate 4-epimerase 1; Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components. (429 aa)
SUS4Sucrose synthase 4; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways; Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily. (808 aa)
NRS/ERBifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase; Bifunctional enzyme involved in dTDP-beta-L-rhamnose biosynthesis. Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-4-keto-alpha-D-glucose to form dTDP-4-keto-beta-L- rhamnose and its reduction to yield dTDP-beta-L-rhamnose. Can form UDP- beta-L-rhamnose from UDP-6-deoxy-4-keto-alpha-D-glucose, but cannot convert GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose. Belongs to the dTDP-4-dehydrorhamnose reductase family. (301 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
GAE2UDP-glucuronate 4-epimerase 2; Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components. (434 aa)
T21E18.7Probable fructokinase-3; May play an important role in maintaining the flux of carbon towards starch formation. (345 aa)
T21E18.8Probable fructokinase-2; May play an important role in maintaining the flux of carbon towards starch formation. (329 aa)
GAE6UDP-glucuronate 4-epimerase 6; Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components. (460 aa)
PMI2-2Mannose-6-phosphate isomerase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (441 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
GAPC2Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro. (338 aa)
SUS6Sucrose synthase 6; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Functions in callose synthesis at the site of phloem sieve elements. (942 aa)
MIO24.3Probable fructokinase-7; May play an important role in maintaining the flux of carbon towards starch formation. (343 aa)
DURPutative UDP-arabinose 4-epimerase 4. (436 aa)
GT20Probable xyloglucan galactosyltransferase GT20; Functions in xyloglucan synthesis by adding side chains to the xylosylated glucan backbone. Involved in the galactosylation of hemicellulose xyloglucan. (561 aa)
XXT5Probable xyloglucan 6-xylosyltransferase 5; Probable xyloglucan xylosyltransferase involved in the biosynthesis of xyloglucan in roots. May act in association with XXT1 and XXT2. Associates with other xyloglucan- synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi ; Belongs to the glycosyltransferase 34 family. (457 aa)
F9E10.24Putative GDP-mannose pyrophosphorylase; 64911-67597. (415 aa)
F28G11.11Probable fructokinase-6, chloroplastic; May play an important role in maintaining the flux of carbon towards starch formation; Belongs to the carbohydrate kinase PfkB family. (384 aa)
F17I23.90Probable mannose-1-phosphate guanylyltransferase 3; Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. (331 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
F28I8.31ADP-glucose pyrophosphorylase family protein. (406 aa)
SUS5Sucrose synthase 5; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Functions in callose synthesis at the site of phloem sieve elements. (836 aa)
GAE4UDP-glucuronate 4-epimerase 4; Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components. (437 aa)
CYT1Mannose-1-phosphate guanylyltransferase 1; Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants. Plays an essential role in plant growth and development and cell-wall architecture. Provides GDP-mannose, used for cell wall carbohydrate biosynthesis, protein N-glycosylation, as well as for the biosynthesis of the antioxidant ascorbate. (361 aa)
PGM3Probable phosphoglucomutase, cytoplasmic 1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (583 aa)
MEE25Putative UDP-arabinose 4-epimerase 2. (417 aa)
GAE3UDP-glucuronate 4-epimerase 3; Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components. (430 aa)
F24G24.60Probable fructokinase-5; May play an important role in maintaining the flux of carbon towards starch formation. (324 aa)
GAPC1Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to [...] (338 aa)
PGICGlucose-6-phosphate isomerase, cytosolic; Belongs to the GPI family. (560 aa)
SUS1Sucrose synthase 1; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways; Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily. (808 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
SUS2Sucrose synthase 2; Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Modulates metabolic homeostasis and directs carbon towards starch synthesis in developing seeds. (807 aa)
HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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