node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GAMMA-H2AX | MER3 | Q9S9K7 | Q5D892 | Probable histone H2AXb; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response [...] | DExH-box ATP-dependent RNA helicase DExH17; DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference- sensitive crossovers (class I meiotic crossover). Belongs to the DExH box helicase family. | 0.548 |
GAMMA-H2AX | RAD51C | Q9S9K7 | Q8GXF0 | Probable histone H2AXb; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response [...] | DNA repair protein RAD51 homolog 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. | 0.840 |
GAMMA-H2AX | XRCC3 | Q9S9K7 | Q9FKM5 | Probable histone H2AXb; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response [...] | DNA repair protein XRCC3 homolog; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair. | 0.775 |
MER3 | GAMMA-H2AX | Q5D892 | Q9S9K7 | DExH-box ATP-dependent RNA helicase DExH17; DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference- sensitive crossovers (class I meiotic crossover). Belongs to the DExH box helicase family. | Probable histone H2AXb; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response [...] | 0.548 |
MER3 | RAD51C | Q5D892 | Q8GXF0 | DExH-box ATP-dependent RNA helicase DExH17; DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference- sensitive crossovers (class I meiotic crossover). Belongs to the DExH box helicase family. | DNA repair protein RAD51 homolog 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. | 0.738 |
MER3 | XRCC3 | Q5D892 | Q9FKM5 | DExH-box ATP-dependent RNA helicase DExH17; DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference- sensitive crossovers (class I meiotic crossover). Belongs to the DExH box helicase family. | DNA repair protein XRCC3 homolog; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair. | 0.523 |
RAD51C | GAMMA-H2AX | Q8GXF0 | Q9S9K7 | DNA repair protein RAD51 homolog 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. | Probable histone H2AXb; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response [...] | 0.840 |
RAD51C | MER3 | Q8GXF0 | Q5D892 | DNA repair protein RAD51 homolog 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. | DExH-box ATP-dependent RNA helicase DExH17; DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference- sensitive crossovers (class I meiotic crossover). Belongs to the DExH box helicase family. | 0.738 |
RAD51C | XRCC3 | Q8GXF0 | Q9FKM5 | DNA repair protein RAD51 homolog 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. | DNA repair protein XRCC3 homolog; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair. | 0.998 |
XRCC3 | GAMMA-H2AX | Q9FKM5 | Q9S9K7 | DNA repair protein XRCC3 homolog; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair. | Probable histone H2AXb; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response [...] | 0.775 |
XRCC3 | MER3 | Q9FKM5 | Q5D892 | DNA repair protein XRCC3 homolog; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair. | DExH-box ATP-dependent RNA helicase DExH17; DNA helicase required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis. Is specific to recombination events resulting in interference- sensitive crossovers (class I meiotic crossover). Belongs to the DExH box helicase family. | 0.523 |
XRCC3 | RAD51C | Q9FKM5 | Q8GXF0 | DNA repair protein XRCC3 homolog; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair. | DNA repair protein RAD51 homolog 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. | 0.998 |