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MSI1 MSI1 MEA MEA IKU1 IKU1 FIS2 FIS2 CDKA-1 CDKA-1 CYCD3-1 CYCD3-1 AP2 AP2 RPS5B RPS5B ACT7 ACT7 clpP1 clpP1 CLE8 CLE8 PHO1-H4 PHO1-H4 WOX8 WOX8 DAR1 DAR1 ARR1 ARR1 ACT2 ACT2 AHK2 AHK2 CKX2 CKX2 HDG6 HDG6 WRKY10 WRKY10 IKU2 IKU2 RBR1 RBR1 CYCD7-1 CYCD7-1 CLPR2 CLPR2 CYP78A6 CYP78A6 RPS5A RPS5A
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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MSI1Histone-binding protein MSI1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair, and the fertilization independent seed (FIS) complex, a polycomb group protein complex which is required to maintain the transcriptionally repr [...] (424 aa)
MEAHistone-lysine N-methyltransferase MEDEA; Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to prevent the proliferation of the central cell of the female gametophyte by repressing target genes before fertilization. After fertilization, it probably also regulates the embryo and endosperm proliferation and anteroposterior organization during seed development. PcG proteins act by forming multiprotein complexes, which are required to maintai [...] (689 aa)
IKU1Protein HAIKU1; Modulates seed size by negatively regulating the cellularization of syncytial endosperm. May function by binding and modulating the activity of WRKY10 transcription factor. (402 aa)
FIS2Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. Regul [...] (755 aa)
CDKA-1Cyclin-dependent kinase A-1; Involved in the control of the cell cycle. Essential for both G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis. Required to trigger guard mother cells (GMC) symmetric divisions at the late stage of stomatal development, probably via the regulation of G1 to S transition in the cell cycle. Required for the function of SPCH in entering the stomatal lineage. Promotes divisions in the guard cells (GCs) after the gu [...] (294 aa)
CYCD3-1Cyclin-D3-1; Involved in the control of the cell cycle at the G1/S (start) transition. Activates the G1/S phase transition in response to cytokinin hormone signal, but declines in response to sucrose starvation leading to G1 arrest. Involved in the induction of mitotic cell division. Plays an important role in the switch from cell proliferation to the final stages of differentiation during plant development. May not be involved in the activation of cell cycle in the root apical meristem (RAM) in the early phase of seed germination. Promotes divisions in the guard cells (GCs) after the [...] (376 aa)
AP2Floral homeotic protein APETALA 2; Probable transcriptional activator that promotes early floral meristem identity. Is required subsequently for the transition of an inflorescence meristem into a floral meristem. Plays a central role in the specification of floral identity, particularly for the normal development of sepals and petals in the wild-type flower, by spatially controlling the expression domains of multiple floral organ identity genes. Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in association with other repressors like LEUNIG and [...] (432 aa)
RPS5B40S ribosomal protein S5-2; Belongs to the universal ribosomal protein uS7 family. (207 aa)
ACT7Actin-7; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins which is involved in the regulation of hormone-induced plant cell proliferation and callus formation. (377 aa)
clpP1Chloroplastic ATP-dependent Clp protease proteolytic subunit 1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. (196 aa)
CLE8CLAVATA3/ESR (CLE)-related protein 8; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Positively regulates the expression of the transcription factor WOX8 and thus, regulates early embryo development. (86 aa)
PHO1-H4Phosphate transporter PHO1 homolog 4; May transport inorganic phosphate (Pi); Belongs to the SYG1 (TC 2.A.94) family. (745 aa)
WOX8WUSCHEL-related homeobox 8; Probable transcription factor, which may be involved in embryonic patterning. May be required for basal embryo development after fertilization. Acts partially redundantly with STIP in promoting embryonic cell division and proliferation. Promotes cotyledon boundary formation by maintaining the symmetry in CUC genes expression domains ; Belongs to the WUS homeobox family. (325 aa)
DAR1Protein DA1-related 1; Acts redundantly with DA1 and DAR2 to regulate endoreduplication during leaf development. Together with DA1 and DAR2, modulates the protein stability of the transcription factors TCP14 and TCP15, which repress endoreduplication by directly regulating the expression of cell-cycle genes. (553 aa)
ARR1Two-component response regulator ARR1; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Regulates SHY2 by binding to its promoter. Involved in the root-meristem size determination through the regulation of cell differentiation. Belon [...] (690 aa)
ACT2Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
AHK2Histidine kinase 2; Cytokinins (CK) receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP- dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedl [...] (1176 aa)
CKX2Cytokinin dehydrogenase 2; Catalyzes the oxidation of cytokinins, a family of N(6)- substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group; Belongs to the oxygen-dependent FAD-linked oxidoreductase family. (501 aa)
HDG6Homeobox-leucine zipper protein HDG6; Probable transcription factor involved in the regulation of time of flowering through the photoperiod flowering pathway. May repress FT. (686 aa)
WRKY10Probable WRKY transcription factor 10; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Modulates seed size by negatively regulating the cellularization of syncytial endosperm. (485 aa)
IKU2Receptor-like protein kinase HAIKU2; Modulates the seed size by negatively regulating the cellularization of syncytial endosperm; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (991 aa)
RBR1Retinoblastoma-related protein 1; Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate. Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation. Plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate m [...] (1013 aa)
CYCD7-1Putative cyclin-D7-1; Belongs to the cyclin family. Cyclin D subfamily. (341 aa)
CLPR2ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic; Required for chloroplast development and integrity. Involved in the regulation of plastoglobules formation. Belongs to the peptidase S14 family. (279 aa)
CYP78A6Cytochrome P450 78A6; Plays role in seed and fruit development. Functions probably in association with CYP78A9 in the regulation of seed growth. Acts maternally to promote seed growth; Belongs to the cytochrome P450 family. (530 aa)
RPS5A40S ribosomal protein S5-1. (207 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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