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CYP735A2 CYP735A2 ARR2 ARR2 ARR6 ARR6 ARR7 ARR7 ARR3 ARR3 IPT7 IPT7 CKX1 CKX1 ARR10 ARR10 ARR9 ARR9 ARR12 ARR12 BEL1 BEL1 ARR15 ARR15 LOG8 LOG8 LOG7 LOG7 LOG3 LOG3 AHP5 AHP5 ARR14 ARR14 LOG5 LOG5 LOG1 LOG1 IPT3 IPT3 ARR1 ARR1 PUP2 PUP2 IPT5 IPT5 IPT1 IPT1 AHK4 AHK4 AHK3 AHK3 AHK2 AHK2 ABCG14 ABCG14 CYP735A1 CYP735A1 ARR18 ARR18 UGT76C1 UGT76C1 ARR17 ARR17 CKX7 CKX7 PUP1 PUP1 LOG4 LOG4 IPT8 IPT8 BHLH32 BHLH32 CKX3 CKX3 CKX6 CKX6 ARR21 ARR21 ARR5 ARR5 WUS WUS AHP6 AHP6 LHW LHW
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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CYP735A2Cytokinin hydroxylase; Cytokinin hydroxylase that catalyzes the biosynthesis of trans-zeatin via the isopentenyladenine riboside 5'-monophosphate (iPRMP)-dependent pathway. Can use isopentenyladenosine-5'- monophosphate, isopentenyladenosine-5'-diphosphate and isopentenyladenosine-5'-triphosphate as substrate. (512 aa)
ARR2Two-component response regulator ARR2; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the expression of nuclear genes for components of mitochondrial complex I. Promotes cytokinin-mediated leaf longevity. Involved in th [...] (664 aa)
ARR6Two-component response regulator ARR6; Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling. Belongs to the ARR family. Type-A subfamily. (186 aa)
ARR7Two-component response regulator ARR7; Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling. Belongs to the ARR family. Type-A subfamily. (206 aa)
ARR3Two-component response regulator ARR3; Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling. (231 aa)
IPT7Adenylate isopentenyltransferase 7, mitochondrial; Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP. (329 aa)
CKX1Cytokinin dehydrogenase 1; Catalyzes the oxidation of cytokinins, a family of N(6)- substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group. (575 aa)
ARR10Two-component response regulator ARR10; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. (552 aa)
ARR9Two-component response regulator ARR9; Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling. Belongs to the ARR family. Type-A subfamily. (234 aa)
ARR12Two-component response regulator ARR12; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the root-meristem size determination through the regulation of cell differentiation. Involved in activating SHY2 during meristem gro [...] (596 aa)
BEL1Homeobox protein BEL1 homolog; Plays a major role in ovule patterning and in determination of integument identity via its interaction with MADS-box factors. Formation of complex with AG-SEP dimers negatively regulates the carpel identity process and favors the maintenance of ovule identity. BEL1-STM complex maintains the indeterminacy of the inflorescence meristem. Required, with SPL, for cytokinin-induced PIN1 expression in ovules. (611 aa)
ARR15Two-component response regulator ARR15; Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling. (206 aa)
LOG8Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG8; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. (216 aa)
LOG7Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG7; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. (217 aa)
LOG3Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG3; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. (215 aa)
AHP5Histidine-containing phosphotransfer protein 5; Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction through the multistep His-to-Asp phosphorelay. (157 aa)
ARR14Two-component response regulator ARR14; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity); Belongs to the ARR family. Type-B subfamily. (382 aa)
LOG5Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG5; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. (228 aa)
LOG1Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG1; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. (213 aa)
IPT3Adenylate isopentenyltransferase 3, chloroplastic; Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP; Belongs to the IPP transferase family. (336 aa)
ARR1Two-component response regulator ARR1; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Regulates SHY2 by binding to its promoter. Involved in the root-meristem size determination through the regulation of cell differentiation. Belon [...] (690 aa)
PUP2Purine permease 2; Mediates adenine transport. May be involved in the uptake of cytokinin analogs; Belongs to the purine permeases (TC 2.A.7.14) family. (358 aa)
IPT5Adenylate isopentenyltransferase 5, chloroplastic; Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP; Belongs to the IPP transferase family. (330 aa)
IPT1Adenylate isopentenyltransferase 1, chloroplastic; Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP, ADP and AMP. Adenine, adenosine, isopentenylpyrophosphate and 1-hydroxy-2- methyl-2-(E)-butenyl 4-diphosphate (HMBDP) are not used as substrates. (357 aa)
AHK4Histidine kinase 4; Cytokinins (CK) receptor related to bacterial two-component regulators. Binds also the synthetic urea-type cytokinin thiadiazuron, a potent defoliant and herbicide. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer [...] (1080 aa)
AHK3Histidine kinase 3; Cytokinins (CK) receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP- dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedl [...] (1036 aa)
AHK2Histidine kinase 2; Cytokinins (CK) receptor related to bacterial two-component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP- dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin, feeds phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedl [...] (1176 aa)
ABCG14ABC transporter G family member 14. (648 aa)
CYP735A1Cytokinin hydroxylase; Cytokinin hydroxylase that catalyzes the biosynthesis of trans-zeatin via the isopentenyladenine riboside 5'-monophosphate (iPRMP)-dependent pathway. Can use isopentenyladenosine-5'- monophosphate, isopentenyladenosine-5'-diphosphate and isopentenyladenosine-5'-triphosphate as substrate. (518 aa)
ARR18Two-component response regulator ARR18; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity). (635 aa)
UGT76C1UDP-glycosyltransferase 76C1; Involved in the N-glucosylation of cytokinins. Catalyzes the formation of both the 7-N and the 9-N-glucosides. (464 aa)
ARR17Two-component response regulator ARR17; Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling (By similarity). (153 aa)
CKX7Cytokinin dehydrogenase 7; Catalyzes the oxidation of cytokinins, a family of N(6)- substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group. (524 aa)
PUP1Purine permease 1; Proton-coupled purine transporter mediating adenine and trans-zeatin uptake. High affinity transporter for pyridoxine involved in the uptake of vitamin B6. Also able to transport caffeine and adenosine. May be involved in the uptake of cytokinin, caffeine and nicotine from the xylem sap into shoot tissues. (356 aa)
LOG4Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG4; Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms. (215 aa)
IPT8Adenylate isopentenyltransferase 8, chloroplastic; Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP. (330 aa)
BHLH32Transcription factor AIG1; Transcription factor required for MONOPTEROS-dependent root initiation in embryo. Transcriptionally controlled by MONOPTEROS. (344 aa)
CKX3Cytokinin dehydrogenase 3; Catalyzes the oxidation of cytokinins, a family of N(6)- substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group. (523 aa)
CKX6Cytokinin dehydrogenase 6; Catalyzes the oxidation of cytokinins, a family of N(6)- substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group; Belongs to the oxygen-dependent FAD-linked oxidoreductase family. (533 aa)
ARR21Putative two-component response regulator ARR21; Putative transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity); Belongs to the ARR family. Type-B subfamily. (613 aa)
ARR5Two-component response regulator ARR5; Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling. Belongs to the ARR family. Type-A subfamily. (184 aa)
WUSProtein WUSCHEL; Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expr [...] (292 aa)
AHP6Pseudo histidine-containing phosphotransfer protein 6; Functions as two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction. (154 aa)
LHWTranscription factor LHW; Transcription activator that regulates root development; promotes the production of stele cells in roots. Coordinately controls the number of all vascular cell types by regulating the size of the pool of cells from which they arise. (650 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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