STRINGSTRING
CLV1 CLV1 CLV3 CLV3 TDR TDR NAC026 NAC026 NAC098 NAC098 ARAC10 ARAC10 ROPGEF4 ROPGEF4 ASK7 ASK7 NAC002 NAC002 WOX4 WOX4 CLE41 CLE41 NAC043 NAC043 ROPGAP3 ROPGAP3 ICR5 ICR5 KIN13A KIN13A CLE44 CLE44 MYB83 MYB83 NAC030 NAC030 RLK RLK K24M7.12 K24M7.12 NAC083 NAC083 BZR2 BZR2 NAC012 NAC012 MYB46 MYB46 WUS WUS TOM5 TOM5 NAC037 NAC037
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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CLV1Receptor protein kinase CLAVATA1; Involved in the detection of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3p as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (980 aa)
CLV3Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family. (96 aa)
TDRLeucine-rich repeat receptor-like protein kinase TDR; Acts with CLE41p and CLE44p peptides as a ligand-receptor pair in a signal transduction pathway involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Mediates repression of tracheary element differentiation and the promotion of procambial cells formation and polar division adjacent to phloem cells in the veins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1041 aa)
NAC026NAC domain-containing protein 26; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls. Belongs to the plant vascular related NAC-domain protein family. (394 aa)
NAC098Protein CUP-SHAPED COTYLEDON 2; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of [...] (375 aa)
ARAC10Rac-like GTP-binding protein ARAC10; Involved in local disassembly of cortical microtubules when associated with ICR5 and KIN13A; Belongs to the small GTPase superfamily. Rho family. (215 aa)
ROPGEF4Rop guanine nucleotide exchange factor 4; Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. In association with ROPGEF1, acts as specific regulator of ARAC10/ROP11 function in ABA-mediated stomatal closure. (463 aa)
ASK7Shaggy-related protein kinase eta; Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5. Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 AND BSK11 in v [...] (380 aa)
NAC002NAC domain-containing protein 2. (289 aa)
WOX4WUSCHEL-related homeobox 4; Transcription factor which may be involved in developmental processes. (251 aa)
CLE41CLAVATA3/ESR (CLE)-related protein 41; Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins in an auxin-dependent manner. (99 aa)
NAC043NAC domain-containing protein 43; Transcription activator of genes involved in biosynthesis of secondary walls. Together with NST2 and NST3, required for the secondary cell wall thickening of sclerenchymatous fibers, secondary xylem (tracheary elements), and of the anther endocethium, which is necessary for anther dehiscence. May also regulate the secondary cell wall lignification of other tissues. (365 aa)
ROPGAP3Rho GTPase-activating protein 3; Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Involved in secondary wall pattern formation. In association with ROPGEF4, mediates local activation of ARAC10/ROP11 to initiate the distinct pattern of secondary cell walls in xylem cells. (455 aa)
ICR5Interactor of constitutive active ROPs 5; ROP effector binding specifically activated ROPs and linking them to the microtubule cytoskeleton. Involved in ROP-regulated polar growth. Involved in local disassembly of cortical microtubules when associated with ARAC10 and KIN13A and conversely mediates also the elimination of ARAC10 from the plasma membrane by the cortical microtubules. Accumulates at the plus end of shrinking microtubules. Targets KIN13A to microtubules. (396 aa)
KIN13AKinesin-like protein KIN-13A; Internal motor kinesin involved in trichome morphogenesis. Participates in regulating the formation of Golgi- associated vesicles. Plays a central role in microtubule disassembly via the active ARAC10-ICR5 cascade, which establishes the secondary cell wall pattern in metaxylem vessel cells. Acts redundantly with KIN13B to modulate cell wall synthesis and cell expansion via the THE1 pathway. (794 aa)
CLE44CLAVATA3/ESR (CLE)-related protein 44; Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins. (112 aa)
MYB83Transcription factor MYB83; Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1 and its close homologs, including NAC043/NST1, NAC066/NST2, NAC101/VND6 and NAC030/VND7. Is required for functional expression of a number of secondary wall-associated transcription factors and secondary wall biosynthetic genes involved in cellulose, xylan and lignin synthesis. Functions redundantly with MYB46 in the transcriptional regulatory cascade leading to secondary wall form [...] (343 aa)
NAC030NAC domain-containing protein 30; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating protoxylem vessel differentiation by promoting immature xylem vessel-specific genes expression. Can activate the expression of several genes including XCP1, MYB46, NAC010/SND3, MYB10 [...] (324 aa)
RLKLeucine-rich repeat receptor-like protein kinase. (751 aa)
K24M7.12VASCULAR-RELATED NAC-DOMAIN 6. (268 aa)
NAC083NAC domain-containing protein 83; Transcriptional repressor that negatively regulates the expression of genes involved in xylem vessel formation. Represses the transcriptional activation activity of NAC030/VND7, which regulates protoxylem vessel differentiation by promoting immature xylem vessel- specific genes expression. Transcriptional activator that regulates the COLD-REGULATED (COR15A and COR15B) and RESPONSIVE TO DEHYDRATION (LTI78/RD29A and LTI65/RD29B) genes by binding directly to their promoters. Mediates signaling crosstalk between salt stress response and leaf aging process. [...] (252 aa)
BZR2Protein BRASSINAZOLE-RESISTANT 2; Positive regulator of brassinosteroid (BR) signaling. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5'-CANNTG-3'(E box) through its N- terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C- terminal domain is probably involved in transcriptional activation. Recruits the transcription elongation factor IWS1 to control BR- regulated gene expression. Forms a trimeric complex with IWS1 and ASHH2/SDG8 to regulate BR-reg [...] (335 aa)
NAC012NAC domain-containing protein 12; Transcriptional activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening and lignification of sclerenchymatous fibers and secondary xylem vessels (tracheary elements). Seems to repress the secondary cell wall thickening of xylary fibers. May also regulate the secondary cell wall lignification of other tissues. Binds to and activates the promoter of MYB46. (358 aa)
MYB46Transcription factor MYB46; Transcription activator. Involved in the regulation of secondary wall biosynthesis in fibers and vessels. Transcription activator of the mannan synthase CSLA9 that recognizes and binds to the DNA consensus sequence 5'-[AG][GT]T[AT]GGT[GA]-3' cis- regulatory element of CSLA9 promoter. Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1. Functions redundantly with MYB83 in the transcriptional regulatory cascade leading to secondary wa [...] (280 aa)
WUSProtein WUSCHEL; Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expr [...] (292 aa)
TOM5Mitochondrial import receptor subunit TOM5 homolog; A component of the complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins; Belongs to the Tom5 family. (54 aa)
NAC037NAC domain-containing protein 37; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls. (365 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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