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SMC6B SMC6B A0A1I9LSE2 A0A1I9LSE2 SCC2 SCC2 CTF7 CTF7 AtWAPL1 AtWAPL1 SGO1 SGO1 PHB1 PHB1 HASPIN HASPIN SCC3 SCC3 HTR4 HTR4 HTR2 HTR2 RAD51 RAD51 SGO2 SGO2 PARP2 PARP2 DMC1 DMC1 CAPH CAPH ESP1 ESP1 MMS21 MMS21 HTR12 HTR12 SYN4 SYN4 SMC2-1 SMC2-1 AtWAPL2 AtWAPL2 PHB7 PHB7 SCC4 SCC4 DYAD DYAD SMC4 SMC4 HTR11 HTR11 SYN3 SYN3 T6J4.12 T6J4.12 MGH3 MGH3 SMC5 SMC5 PANS1 PANS1 F10A5.19 F10A5.19 CAPH2 CAPH2 T24H18.80 T24H18.80 PCNA PCNA SYN1 SYN1 PHB6 PHB6 PHB2 PHB2 PCNA2 PCNA2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SMC6BStructural maintenance of chromosomes protein 6B; Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (1057 aa)
A0A1I9LSE2Cyclin B1. (100 aa)
SCC2Sister chromatid cohesion protein SCC2; Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion during meiosis and mitosis. Forms a complex with SCC4, which is required for the association of the cohesin complex with chromosomes. Plays a structural role in chromatin, especially in centromere organization, chromosomal axis formation, and distribution of the cohesin subunit SCC3 on chromosomes. (1846 aa)
CTF7Protein CHROMOSOME TRANSMISSION FIDELITY 7; Acetyltransferase required for the establishment of sister chromatid cohesion. Involved in preservation of genome integrity and meiosis. Required for DNA repair and for the regulation of chromosome segregation during mitotic cell division. Knock-down mutants are extremely dwarf. (345 aa)
AtWAPL1WAPL (Wings apart-like protein regulation of heterochromatin) protein. (930 aa)
SGO1SHUGOSHIN 1; Protects sister chromatid centromere cohesion in meiosis I but not through the protection of the cohesin SYN1. Required with SGO2 for full protection of centromeric cohesion during anaphase I. Required to prevent precocious release of pericentromeric cohesins during meiosis. Not necessary for the maintenance of the synaptonemal complex (SC). Not required for monopolar spindle orientation in meiosis I. (572 aa)
PHB1Prohibitin-1, mitochondrial; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. (288 aa)
HASPINSerine/threonine-protein kinase haspin homolog; Threonine-protein kinase that phosphorylates histone H3 in vitro at 'Thr-3' (H3T3ph) and 'Thr-11' (H3T11ph), but not at 'Ser-10' (H3S10ph) or 'Ser-28' (H3S28ph). Plays a role in mitotic cell division during plant growth. Threonine-protein kinase that phosphorylates histone H3 in vitro at 'Thr-3' (H3T3ph), but not at 'Thr-11' (H3T11ph), 'Ser-10' (H3S10ph) or 'Ser-28' (H3S28ph). Involved in histone H3 phosphorylation in mitotic cells. Contributes to organ and plant development, as well as embryonic patterning. (599 aa)
SCC3Sister-chromatid cohesion protein 3; Essential component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Required for centromere cohesion maintenance at anaphase I and for the monopolar orientation of the kinetochores during both male and [...] (1098 aa)
HTR4Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
HTR2Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (136 aa)
RAD51DNA repair protein RAD51 homolog 1; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis. (342 aa)
SGO2SHUGOSHIN 2; Dispensable for both meiotic and mitotic cell cycle progression. Required with SGO1 for full protection of centromeric cohesion during anaphase I. Required to prevent precocious release of pericentromeric cohesins during meiosis. Acts redundantly to SGO1 ; Belongs to the shugoshin family. (470 aa)
PARP2Poly [ADP-ribose] polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity). (637 aa)
DMC1Meiotic recombination protein DMC1 homolog; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Mediates interhomolog recombination during meiosis. (344 aa)
CAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Essential protein. (671 aa)
ESP1Separase; Cleaves SYN1, releasing sister chromatid cohesion. Required for the release of cohesin at anaphase I and anaphase II, whereas the release of cohesin during diplotene and diakinesis occurs in a separase-independent process. Essential for embryo and endosperm development. May play a role in centromeric heterochromatin structure/formation during early meiosis, non-homologous centromere association and radial microtubule system (RMS) formation. May regulate the mitosis-specific cyclin CYCB1-1. (2180 aa)
MMS21E3 SUMO-protein ligase MMS21; E3 SUMO-protein ligase that modulates cell cycle progression and functions as a repressor of endocycle onset in meristems. May function downstream of the meristem patterning transcription factors PLETHORA 1 and 2 (PLT1 and PLT2) in root meristem development. Modulates the expression of the mitotic cyclins CYCB1-1 and CYCB1-2 and cyclin-dependent kinases CDKB1-1 and CDKB2-1 in root meristem. Involved in cytokinin signaling in root development. Belongs to the NSE2 family. (249 aa)
HTR12Histone H3-like centromeric protein HTR12; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). (178 aa)
SYN4Sister chromatid cohesion 1 protein 4; Involved in sister chromatid and centromere cohesion during mitosis. (1031 aa)
SMC2-1Structural maintenance of chromosomes protein 2-1; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis. (1175 aa)
AtWAPL2WAPL (Wings apart-like protein regulation of heterochromatin) protein. (840 aa)
PHB7Prohibitin-7, mitochondrial; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. (278 aa)
SCC4Sister chromatid cohesion protein SCC4; Essential protein required for cell fate determination during embryogenesis. Involved in sister chromatid cohesion. Forms a complex with SCC2, which is required for the association of the cohesin complex with chromosomes. (726 aa)
DYADProtein DYAD; Required for fertility. Involved in chromatid cohesion establishment, in chromosome structure during male and female meiosis (e.g. the synapse formation between homologous chromosomes, the recombination, and the cohesion of both chromatid arm and centromere), and in axial element formation. Regulates the switch from mitosis to the reductional meiosis division of megaspores prior to the female gametogenesis (megasporogenesis). (639 aa)
SMC4Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Also involved in chromosome segregation in meiosis; Belongs to the SMC family. SMC4 subfamily. (1241 aa)
HTR11Histone H3-like 5; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (139 aa)
SYN3Sister chromatid cohesion 1 protein 3; May be involved in sister chromatid cohesion during mitosis. (693 aa)
T6J4.12Histone H3-like 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
MGH3Histone H3-like 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (137 aa)
SMC5Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids; Belongs to the SMC family. SMC5 subfamily. (1053 aa)
PANS1Protein PATRONUS 1; Required for the maintenance of centromeric cohesion during interkinesis, until meiosis II. Required for regular configuration and segregation of sister chromatids in meiosis II. Also required for centromere cohesion during meiosis I. Involved in spindle organization at the end of telophase I and in meiosis II. Required to prevent precocious release of pericentromeric cohesins during meiosis, but not for cohesion establishment and monopolar orientation of kinetochores at meiosis I. Involved also in somatic development. Regulates mitotic cell division and ploidy stab [...] (193 aa)
F10A5.19Histone H3-like 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa)
CAPH2Condensin-2 complex subunit H2; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). The condensin-2 complex plays a role in DNA damage repair or in protecting the genome from certain genotoxic stressors (e.g. boron excess, zeocin and aphidicolin); Belongs to the CND2 H2 (condensin-2 subunit 2) family. (683 aa)
T24H18.80Histone H3-like 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (131 aa)
PCNAProliferating cellular nuclear antigen 1; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
SYN1Sister chromatid cohesion 1 protein 1; Involved in chromosome condensation, pairing and segregation during meiosis. Responsible for cohesion between replicated sister chromatids. (627 aa)
PHB6Prohibitin-6, mitochondrial; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. (286 aa)
PHB2Prohibitin-2, mitochondrial; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. (286 aa)
PCNA2Proliferating cell nuclear antigen 2; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity). May be involved in UV resistance. Belongs to the PCNA family. (264 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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