STRINGSTRING
BHLH2 BHLH2 HEC1 HEC1 TDR TDR MYC3 MYC3 PRE1 PRE1 BIM3 BIM3 SAC51 SAC51 UBC18 UBC18 GL3 GL3 MEE8 MEE8 TT8 TT8 BHLH101 BHLH101 BIM1 BIM1 SCRM SCRM HEC3 HEC3 ORG3 ORG3 ORG2 ORG2 MUTE MUTE PAR1 PAR1 BHLH47 BHLH47 BHLH51 BHLH51 LHW LHW BHLH66 BHLH66 BHLH100 BHLH100 UPB1 UPB1 MYC4 MYC4 PIF3 PIF3 DYT1 DYT1 ACO4 ACO4 MYC2 MYC2 TIP1-2 TIP1-2 BHLH71 BHLH71 FAMA FAMA BHLH72 BHLH72 BHLH130 BHLH130 SPCH SPCH BHLH27 BHLH27 BHLH84 BHLH84 PIF5 PIF5 BHLH85 BHLH85 BEE3 BEE3 BHLH63 BHLH63 BEE1 BEE1 UNE10 UNE10 BHLH104 BHLH104 PIF6 PIF6 BHLH54 BHLH54 BHLH12 BHLH12 NIG NIG BHLH112 BHLH112 BHLH76 BHLH76 BHLH115 BHLH115 BHLH83 BHLH83 BHLH80 BHLH80 BIM2 BIM2 HFR1 HFR1 NFXL2 NFXL2 ILR3 ILR3
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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BHLH2Transcription factor EGL1; Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involve [...] (596 aa)
HEC1Transcription factor HEC1; Required for the female reproductive tract development and fertility. (241 aa)
TDRLeucine-rich repeat receptor-like protein kinase TDR; Acts with CLE41p and CLE44p peptides as a ligand-receptor pair in a signal transduction pathway involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Mediates repression of tracheary element differentiation and the promotion of procambial cells formation and polar division adjacent to phloem cells in the veins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1041 aa)
MYC3Transcription factor MYC3; Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. (592 aa)
PRE1Transcription factor PRE1; Atypical and probable non DNA-binding bHLH transcription factor that integrates multiple signaling pathways to regulate cell elongation and plant development. Binds IBH1, forming a pair of antagonistic bHLH transcription factors that function downstream of BZR1 to mediate brassinosteroid regulation of cell elongation. Regulates light responses by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance. May have a regulatory role in various aspects of gibberellin-dependent growth an [...] (92 aa)
BIM3Transcription factor BIM3; Positive brassinosteroid-signaling protein. (298 aa)
SAC51Transcription factor SAC51; Transcription factor. Involved in stem elongation, probably by regulating a subset of genes involved in this process. Belongs to the bHLH protein family. (348 aa)
UBC18Probable ubiquitin-conjugating enzyme E2 18; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. (161 aa)
GL3Transcription factor GLABRA 3; Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication. Regulates also trichome cell wall maturation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell form [...] (637 aa)
MEE8Transcription factor MEE8; Required during early embryo development, for the endosperm formation. (145 aa)
TT8Transcription factor TT8; Transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2. Involved in the control of flavonoid pigmentation. Plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). Not required for leucoanthocyanidin dioxygenase (LDOX) expression. (518 aa)
BHLH101Transcription factor bHLH101. (240 aa)
BIM1Transcription factor BIM1; Positive brassinosteroid-signaling protein. Transcription factor that bind specifically to the DNA sequence 5'-CANNTG-3'(E box). Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BZR2/BES1. Does not itself activate transcription but enhances BZR2/BES1-mediated target gene activation. (529 aa)
SCRMTranscription factor ICE1; Transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. Binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA. Functions as a dimer with SPCH during stomatal initiation. (494 aa)
HEC3Transcription factor HEC3; Required for the female reproductive tract development and fertility. (224 aa)
ORG3Transcription factor ORG3. (258 aa)
ORG2Transcription factor ORG2. (253 aa)
MUTETranscription factor MUTE; Transcription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata. (202 aa)
PAR1Transcription factor PAR1; Atypical bHLH transcription factor that acts as negative regulator of a variety of shade avoidance syndrome (SAS) responses, including seedling elongation and photosynthetic pigment accumulation. Acts as direct transcriptional repressor of two auxin-responsive genes, SAUR15 and SAUR68. May function in integrating shade and hormone transcriptional networks in response to light and auxin changes. (118 aa)
BHLH47Transcription factor bHLH47. (240 aa)
BHLH51Transcription factor bHLH51. (254 aa)
LHWTranscription factor LHW; Transcription activator that regulates root development; promotes the production of stele cells in roots. Coordinately controls the number of all vascular cell types by regulating the size of the pool of cells from which they arise. (650 aa)
BHLH66Transcription factor bHLH66. (350 aa)
BHLH100Transcription factor bHLH100; Plays a role in metal homeostasis. Confers tolerance to high zinc (Zn) and nickel (Ni). (242 aa)
UPB1Transcription factor UPBEAT1; Transcription factor that modulates the balance between cellular proliferation and differentiation in root growth. Does not act through cytokinin and auxin signaling, but by repressing peroxidase expression in the elongation zone. (102 aa)
MYC4Transcription factor MYC4; Transcription factor involved in jasmonic acid (JA) gene regulation. With MYC2 and MYC3, controls additively subsets of JA- dependent responses. Can form complexes with all known glucosinolate- related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. (589 aa)
PIF3Transcription factor PIF3; Transcription factor acting positively in the phytochrome signaling pathway. Activates transcription by binding to the G box (5'- CACGTG-3'). (524 aa)
DYT1Transcription factor DYT1; Transcription factor. Involved in the control of tapetum development. Required for male fertility and pollen differentiation, especially during callose deposition. (207 aa)
ACO41-aminocyclopropane-1-carboxylate oxidase 4; Enzyme involved in the ethylene biosynthesis. May promote stem elongation by maximizing the extensibility cells, possibly by activating ethylene biosynthesis, in response to very-long-chain fatty acids (VLCFAs C20:0 to C30:0); Belongs to the iron/ascorbate-dependent oxidoreductase family. (323 aa)
MYC2Transcription factor MYC2; Transcriptional activator. Common transcription factor of light, abscisic acid (ABA), and jasmonic acid (JA) signaling pathways. With MYC3 and MYC4, controls additively subsets of JA-dependent responses. In cooperation with MYB2 is involved in the regulation of ABA-inducible genes under drought stress conditions. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the MYC recognition site (5'-CACATG-3'), and to the G-box (5'-CACNTG-3') and Z-box (5'-ATACGTGT-3') of promoters. Binds directly to the prom [...] (623 aa)
TIP1-2Aquaporin TIP1-2; Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition. Transports urea in yeast cells in a pH-independent manner. Transports H(2)O(2) in yeast cells. (253 aa)
BHLH71Transcription factor bHLH71; Transcription factor. May be involved in the differentiation of stomatal guard cells. (327 aa)
FAMATranscription factor FAMA; Transcription activator. Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity. Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata. Prevents histone H3K27me3 marks and derepresses stem cell gene expression. (414 aa)
BHLH72Transcription factor PIF7; Transcription factor acting negatively in the phytochrome B signaling pathway under prolonged red light. Regulates PHYB abundance at the post-transcriptional level, possibly via the ubiquitin- proteasome pathway. May regulate the expression of a subset of genes by binding to the G-box motif. (366 aa)
BHLH130Transcription factor bHLH130. (359 aa)
SPCHTranscription factor SPEECHLESS; Transcription factor acting as an integration node for stomata and brassinosteroid (BR) signaling pathways to control stomatal initiation and development. Activates transcription when in the presence of SCRM/ICE1. Functions as a dimer with SCRM or SCRM2 during stomatal initiation. Required for the initiation, the spacing and the formation of stomata, by promoting the first asymmetric cell divisions. Together with FMA and MUTE, modulates the stomata formation. Involved in the regulation of growth reduction under osmotic stress (e.g. mannitol), associated [...] (364 aa)
BHLH27Transcription factor bHLH27. (263 aa)
BHLH84Transcription factor bHLH84; Belongs to the bHLH protein family. (328 aa)
PIF5Transcription factor PIF5; Transcription factor acting negatively in the phytochrome B signaling pathway to promote the shade-avoidance response. Regulates PHYB abundance at the post-transcriptional level, possibly via the ubiquitin-proteasome pathway. Promotes ethylene activity in the dark. May regulate the expression of a subset of genes by binding to the G- box motif. Might be involved in the integration of light-signals to control both circadian and photomorphogenic processes. Activated by CRY1 and CRY2 in response to low blue light (LBL) by direct binding at chromatin on E-box var [...] (444 aa)
BHLH85Transcription factor bHLH85. (352 aa)
BEE3Transcription factor BEE 3; Positive regulator of brassinosteroid signaling. (261 aa)
BHLH63Transcription factor bHLH63; Transcription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. (335 aa)
BEE1Transcription factor BEE 1; Positive regulator of brassinosteroid signaling. (260 aa)
UNE10Transcription factor UNE10; Required during the fertilization of ovules by pollen. (399 aa)
BHLH104Transcription factor bHLH104. (283 aa)
PIF6Transcription factor PIF6. (363 aa)
BHLH54Transcription factor bHLH54. (258 aa)
BHLH12Transcription factor MYC1; Trancsription activator, when associated with MYB75/PAP1 or MYB90/PAP2. (526 aa)
NIGNSP (Nuclear shuttle protein)-interacting GTPase. (602 aa)
BHLH112Transcription factor bHLH112. (393 aa)
BHLH76Transcription factor bHLH76; Transcriptional activator involved in cell elongation. Regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. (390 aa)
BHLH115Transcription factor bHLH115. (226 aa)
BHLH83Transcription factor bHLH83. (298 aa)
BHLH80Transcription factor bHLH80. (259 aa)
BIM2Transcription factor BIM2; Positive brassinosteroid-signaling protein. (311 aa)
HFR1Transcription factor HFR1; Atypical bHLH transcription factor that regulates photomorphogenesis through modulation of phytochrome (e.g. PHYA) and cryptochrome signalings (Ref.4,. Suppresses the transcriptional regulation activity of PIF4 by forming non-DNA-binding heterodimer. (292 aa)
NFXL2NF-X1-type zinc finger protein NFXL2; Probable transcriptional regulator. May mediate E2- or E3- dependent ubiquitination. Required to gate light sensitivity during the night. Regulates the speed of the clock by acting in the feedback loop between CCA1, LHY and APRR1/TOC1. Promotes the expression of CCA1 at night but not by days. This activational effect is enhanced by interaction with ADO1/ZTL. Association with ADO1/ZTL is not leading to the degradation of NFXL2. Confers sensitivity to osmotic stress such as high salinity. Prevents H(2)O(2) production and abscisic acid accumulation. P [...] (883 aa)
ILR3Transcription factor ILR3; Transcription factor. Plays a role in resistance to amide- linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA- Phe. May regulate gene expression in response to metal homeostasis changes. (234 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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