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HOS15 HOS15 TPR14 TPR14 SARD1 SARD1 SLK2 SLK2 SEU SEU RPS4-2 RPS4-2 AFPH2 AFPH2 PME45 PME45 PME24 PME24 PCR8 PCR8 GH3.12 GH3.12 FMO1 FMO1 LUG LUG CYS2 CYS2 TPL TPL B3H7M7_ARATH B3H7M7_ARATH F4JKT1_ARATH F4JKT1_ARATH HDA19 HDA19 SNC1 SNC1 SNL3 SNL3 LUH LUH PME3 PME3 SAP18 SAP18 TO1 TO1 PME40 PME40 RRS1 RRS1 SLK1 SLK1 T25N20.10 T25N20.10 PME18 PME18 PME42 PME42 PME28 PME28 ZAT12 ZAT12 PME2 PME2 PME1 PME1 PME56 PME56
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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HOS15WD40 repeat-containing protein HOS15; Acts as repressor of cold stress-regulated gene expression. Interacts specifically with and promotes deacetylation of histone H4. Plays a role in gene regulation for plant acclimation and tolerance to cold stress. (613 aa)
TPR14Tetratricopeptide repeat (TPR)-containing protein. (593 aa)
SARD1Protein SAR DEFICIENT 1; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P. syringae pv. maculicola and Hyaloperonospora arabidopsidis. Belongs to the plant ACBP60 prote [...] (451 aa)
SLK2Probable transcriptional regulator SLK2; Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression. DNA-binding adapter subunit of the SEU-SLK2 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes. (816 aa)
SEUTranscriptional corepressor SEUSS; DNA-binding adapter subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and LEUNIG to repress AGAMOUS expression. In association with LUG, regulates petal shape through AGAMOUS-independent mechanisms. Controls cell division during petal development and enable the proper patterning of petal [...] (877 aa)
RPS4-2Disease resistance protein RPS4; Disease resistance (R) protein that specifically recognizes the AvrRps4 type III effector avirulence protein from P.syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage trigge [...] (1217 aa)
AFPH2AFP homolog 2; Acts as a transcriptional repressor. Negative regulator of jasmonate responses. Connects the JAZ proteins and the non-JAZ protein TIFY8 with the TOPLESS corepressors; Belongs to the Ninja family. (425 aa)
PME45Putative pectinesterase/pectinesterase inhibitor 45; Acts in the modification of cell walls via demethylesterification of cell wall pectin; In the N-terminal section; belongs to the PMEI family. (609 aa)
PME24Putative pectinesterase/pectinesterase inhibitor 24; Acts in the modification of cell walls via demethylesterification of cell wall pectin; In the C-terminal section; belongs to the pectinesterase family. (561 aa)
PCR8Protein PLANT CADMIUM RESISTANCE 8; May be involved in heavy metals transport; Belongs to the cornifelin family. (190 aa)
GH3.124-substituted benzoates-glutamate ligase GH3.12; Catalyzes the conjugation of specific amino acids (e.g. Glu and possibly His, Lys, and Met) to their preferred acyl substrates (e.g. 4-substituted benzoates), in a magnesium ion- and ATP-dependent manner. Can use 4-substituted benzoates such as 4-aminobenzoate (pABA), 4-fluorobenzoate and 4-hydroxybenzoate (4-HBA), and, to a lesser extent, benzoate, vanillate and trans-cinnamate, but not 2-substituted benzoates and salicylic acid (SA), as conjugating acyl substrates. Involved in both basal and induced resistance in a SA-dependent manner. [...] (575 aa)
FMO1Probable flavin-containing monooxygenase 1; Required for the establishment of systemic acquired resistance (SAR). Not involved in local defense mechanisms. Confers a salicylic acid-dependent (SA) resistance to virulent pathogens such as P.syringae pv tomato and H.parasitica. (530 aa)
LUGTranscriptional corepressor LEUNIG; Transcription repressor subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and SEUSS to repress AGAMOUS expression. Also plays a role in ovule and pollen development. Implicated in embryo and floral development. Involved in post-synthesis cell wall modifications necessary for mucilage ext [...] (931 aa)
CYS2Cysteine proteinase inhibitor 2; Specific inhibitor of cysteine proteinases. Probably involved in the regulation of endogenous processes and in defense against pests and pathogens (By similarity); Belongs to the cystatin family. Phytocystatin subfamily. (147 aa)
TPLProtein TOPLESS; Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes. Required for ovule development. (1131 aa)
B3H7M7_ARATHCorepressor. (170 aa)
F4JKT1_ARATHHistone deacetylase. (70 aa)
HDA19Histone deacetylase 19; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous flora [...] (501 aa)
SNC1Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1; Disease resistance protein of the TIR-NB-LRR-type. Part of the RPP5 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D- ribose (ADPR) an [...] (1437 aa)
SNL3Paired amphipathic helix protein Sin3-like 3; Acts as a transcriptional repressor. Interacts with ERF7 to repress genes in abscisic acid and drought stress responses. The heterodimer represses transcription by tethering SNL3 to DNA. (1330 aa)
LUHTranscriptional corepressor LEUNIG_HOMOLOG; Transcription repressor subunit of the SEU-SLK1 and SEU-SLK2 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes, by means of an epigenetic process involving histone modification (e.g. H3K9 and H3K14 acetylation), probably by recruiting HDAC, to facilitate the condensation of chromatin thus preventing transcription at the target genes. Can also act as a transcription activator. Implicated in embryo and floral development. Involved in post- synthesis cell wall modifications necessary for mucilage extrusi [...] (787 aa)
PME3Pectinesterase/pectinesterase inhibitor 3; Acts in the modification of cell walls via demethylesterification of cell wall pectin; In the C-terminal section; belongs to the pectinesterase family. (592 aa)
SAP18Histone deacetylase complex subunit SAP18; Links the histone deacetylase complex to transcriptional repressors bound to chromatin. Involved in the tethering of the SIN3 complex to core histone proteins. (152 aa)
TO1Thioredoxin O1, mitochondrial; Thiol-disulfide oxidoreductase that may participate in various redox reactions. Possesses insulin disulfide bonds reducing activity. Reduced by thioredoxin reductases NTRA and NTRB. Belongs to the thioredoxin family. Plant O-type subfamily. (194 aa)
PME40Probable pectinesterase/pectinesterase inhibitor 40; Acts in the modification of cell walls via demethylesterification of cell wall pectin; In the N-terminal section; belongs to the PMEI family. (518 aa)
RRS1Disease resistance protein RRS1; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Acts also as a disease resistance protein involved in resistance to fungal and bacterial pathogens, including R.solanacearum, P.syringae pv. tomato and C.higginsianum. Heterodimerization with RPS4 is required to form a functional complex to recognize AvrRps4 and PopP2. Contributes to temperature-conditioned RPS4 auto- immunity. (1288 aa)
SLK1Probable transcriptional regulator SLK1; Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression. DNA-binding adapter subunit of the SEU-SLK1 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes. (748 aa)
T25N20.10Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein. (205 aa)
PME18Bifunctional pectinesterase 18/rRNA N-glycosylase; Acts in the modification of cell walls via demethylesterification of cell wall pectin. Inhibits the elongation phase of protein synthesis; In the N-terminal section; belongs to the PMEI family. (557 aa)
PME42Probable pectinesterase/pectinesterase inhibitor 42; Acts in the modification of cell walls via demethylesterification of cell wall pectin; In the C-terminal section; belongs to the pectinesterase family. (524 aa)
PME28Putative pectinesterase/pectinesterase inhibitor 28; Acts in the modification of cell walls via demethylesterification of cell wall pectin; In the N-terminal section; belongs to the PMEI family. (732 aa)
ZAT12Zinc finger protein ZAT12; Transcriptional repressor involved in light acclimation, cold and oxidative stress responses. May regulate a collection of transcripts involved in response to high-light, cold and oxidative stress. (162 aa)
PME2Pectinesterase 2; Acts in the modification of cell walls via demethylesterification of cell wall pectin; In the N-terminal section; belongs to the PMEI family. (587 aa)
PME1Pectinesterase 1; Acts in the modification of cell walls via demethylesterification of cell wall pectin (By similarity). Demethylates protein phosphatase 2A (PP2A) that have been reversibly carboxymethylated by LCMT1. Acts as negative regulators of genes involved in salt stress response. In the C-terminal section; belongs to the pectinesterase family. (586 aa)
PME56Probable pectinesterase 56; Acts in the modification of cell walls via demethylesterification of cell wall pectin; Belongs to the pectinesterase family. (288 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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