STRINGSTRING
RECA RECA RAD51 RAD51 NBS1 NBS1 DMC1 DMC1 RAD51C RAD51C MND1 MND1 GIF1 GIF1 SMO2-2 SMO2-2 XRCC3 XRCC3 RAD51D RAD51D SAE2 SAE2 RAD51B RAD51B RAD50 RAD50 SKD1 SKD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RECADNA repair protein recA homolog 1, chloroplastic; Involved in recombination ability and DNA strand transfer activity. (439 aa)
RAD51DNA repair protein RAD51 homolog 1; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Unwinds duplex DNA (By similarity). Component of the meiotic recombination pathway. Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis. Probably is involved in the repair of meiotic double strand breaks (DBSs) generated by AtSPO11-1 and in homologous recombination. Its function is dispensable for vegetative growth and root mitosis. (342 aa)
NBS1Nijmegen breakage syndrome 1 protein; Component of the MRE11-RAD50-NBN complex (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex may be involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, and cell cycle checkpoint control. Functions also in the very early stages of meiosis. (542 aa)
DMC1Meiotic recombination protein DMC1 homolog; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Mediates interhomolog recombination during meiosis. (344 aa)
RAD51CDNA repair protein RAD51 homolog 3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. (363 aa)
MND1Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1/LIM15- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double- strand breaks. (230 aa)
GIF1GRF1-interacting factor 1; Transcription coactivator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation. Appears to function synergistically with GRF1 as a transcriptional coactivator. Acts together with GRF5 for the development of appropriate leaf size and shape through the promotion and/or maintenance of cell proliferation activity in leaf primordia. Plays a [...] (210 aa)
SMO2-2Methylsterol monooxygenase 2-2; Non-heme iron oxygenase involved in sterols biosynthesis. 24- ethylidenelophenol and 24-ethyllophenol are the preferred substrates. (266 aa)
XRCC3DNA repair protein XRCC3 homolog; Plays essential roles in DNA damage repair in both somatic and meiotic cells. It is important for postsynaptic events following pachytene in meiosis. It is also required for DNA cross-links repair and is involved in double strand breaks (DSBs) repair. (304 aa)
RAD51DDNA repair protein RAD51 homolog 4; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. (322 aa)
SAE2SUMO-activating enzyme subunit 2; The dimeric enzyme acts as an E1 ligase for SUMO1 and SUMO2. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2. Belongs to the ubiquitin-activating E1 family. (700 aa)
RAD51BDNA repair protein RAD51 homolog 2; May be involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (370 aa)
RAD50DNA repair protein RAD50; Implicated in double-strand breaks (DSBs) repair by non- homologous end joining (NHEJ). Involved in telomere maintenance. Involved in telomerase action on chromosome ends. Required during meiosis for both male and female gametophytic development, for pairing and synapsis of homologous chromosomes during the early stages of meiotic recombination, especially during the pachytene stage of the first division. Belongs to the SMC family. RAD50 subfamily. (1316 aa)
SKD1Protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1; Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. May also regulate cell cycle. Required during seed development for the formation of mucilage in seed coat and testa. Involved in the maintenance of Na(+)/K(+) homeostasis under salt stress. Required for cell expansion. (435 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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