STRINGSTRING
F26H6.12 F26H6.12 F14M19.50 F14M19.50 GGH2 GGH2 DTX37 DTX37 EIF(ISO)4G2 EIF(ISO)4G2 DTX49 DTX49 IPS1 IPS1 NPF6.3 NPF6.3 NPY5 NPY5 F16M19.18 F16M19.18 FER1 FER1 UBC24 UBC24 PHR1 PHR1 F27M3_4 F27M3_4 MED19A MED19A BSK6 BSK6 FUT4 FUT4 GGH1 GGH1 GGH3 GGH3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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F26H6.12Fucosyltransferase. (80 aa)
F14M19.50Alpha/beta-Hydrolases superfamily protein. (422 aa)
GGH2Gamma-glutamyl hydrolase 2; Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role on folate stability and intracellular folate content. Has endopeptidase activity against 4- amino-10-methylpteroyl penta-, tetra-, tri- and di-gamma-L-glutamate substrates and is responsible for the production of folic acid, also called pteroylglutamic acid (PteGlu) from teroylpolyglutamates. Belongs to the peptidase C26 family. (347 aa)
DTX37Protein DETOXIFICATION 37. (501 aa)
EIF(ISO)4G2Eukaryotic translation initiation factor isoform 4G-2; Plays a role in the accumulation of some potyvirus during viral infection. (747 aa)
DTX49Protein DETOXIFICATION 49. (502 aa)
IPS1Inositol-3-phosphate synthase isozyme 1; Catalyzes the majority of myo-inositol synthesis required for plant growth and development. Acts as a repressor of programmed cell death and protects plant cells against cell death under high light intensity or long days. Controls its own transcription by inhibiting ATXR6 activity. Reduces the deposition of inhibitory histone marks on its own promoter; Belongs to the myo-inositol 1-phosphate synthase family. (511 aa)
NPF6.3Protein NRT1/ PTR FAMILY 6.3; Dual affinity nitrate transporter. Involved in proton- dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be i [...] (590 aa)
NPY5BTB/POZ domain-containing protein NPY5; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses; Belongs to the NPH3 family. (580 aa)
F16M19.18SPX domain-containing membrane protein At1g63010; Belongs to the major facilitator superfamily. (697 aa)
FER1Ferritin-1, chloroplastic; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). (255 aa)
UBC24Probable ubiquitin-conjugating enzyme E2 24; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability. Negatively regulates the protein abundance of PHF1 and PHT1s under Pi- sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane. (907 aa)
PHR1Protein PHOSPHATE STARVATION RESPONSE 1; Transcription factor involved in phosphate starvation signaling. Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation- responsive genes. SPX1 is a competitive inhibitor of this DNA-binding. PHR1 binding to its targets is low Pi-dependent. Regulates the expression of miR399. Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions. Regulates lipid remodeling and [...] (409 aa)
F27M3_4SWIB/MDM2 domain superfamily protein. (112 aa)
MED19AMediator of RNA polymerase II transcription subunit 19a; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general [...] (221 aa)
BSK6Serine/threonine-protein kinase BSK6; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Functions redundantly with BSK3, BSK4, BSK7 and BSK8. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (490 aa)
FUT4Probable fucosyltransferase 4; May be involved in cell wall biosynthesis. May act as a fucosyltransferase; Belongs to the glycosyltransferase 37 family. (535 aa)
GGH1Gamma-glutamyl hydrolase 1; Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role in folate stability and intracellular folate content; Belongs to the peptidase C26 family. (348 aa)
GGH3Probable gamma-glutamyl hydrolase 3; Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role on folate stability and intracellular folate content (By similarity). (352 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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