node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABA3 | ATG7 | Q9C5X8 | Q94CD5 | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. Modulates cold stress- and osmotic stress-responsive gene expression by acting as key regulator of abscisic acid (ABA) biosynthesis. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing. | 0.446 |
ABA3 | DES1 | Q9C5X8 | F4K5T2 | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. Modulates cold stress- and osmotic stress-responsive gene expression by acting as key regulator of abscisic acid (ABA) biosynthesis. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily. | Bifunctional cystathionine gamma-lyase/cysteine synthase; Involved in maintaining Cys homeostasis through the desulfuration of L-cysteine. Modulates the generation of the signaling molecule sulfide in plant cytosol. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein. | 0.473 |
APX1 | EMB2360 | Q05431 | P42770 | L-ascorbate peroxidase 1, cytosolic; Plays a key role in hydrogen peroxide removal. Constitutes a central component of the reactive oxygen gene network. | Glutathione reductase, chloroplastic; Maintains high levels of reduced glutathione in the chloroplast. | 0.847 |
APX1 | GAPC1 | Q05431 | P25858 | L-ascorbate peroxidase 1, cytosolic; Plays a key role in hydrogen peroxide removal. Constitutes a central component of the reactive oxygen gene network. | Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to [...] | 0.669 |
ATG10 | ATG18A | Q8VZ52 | Q93VB2 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | 0.934 |
ATG10 | ATG3 | Q8VZ52 | Q0WWQ1 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. | 0.978 |
ATG10 | ATG4A | Q8VZ52 | Q8S929 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | Cysteine protease ATG4a; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes; Belongs to the peptidase C54 family. | 0.916 |
ATG10 | ATG4B | Q8VZ52 | Q9M1Y0 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | Cysteine protease ATG4b; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes. | 0.939 |
ATG10 | ATG7 | Q8VZ52 | Q94CD5 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing. | 0.998 |
ATG10 | CCME | Q8VZ52 | Q96326 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | Cytochrome c-type biogenesis protein CcmE homolog, mitochondrial; Heme-binding chaperone that may be involved in cytochrome c maturation in mitochondria; Belongs to the CcmE/CycJ family. | 0.898 |
ATG18A | ATG10 | Q93VB2 | Q8VZ52 | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | 0.934 |
ATG18A | ATG3 | Q93VB2 | Q0WWQ1 | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. | 0.877 |
ATG18A | ATG4A | Q93VB2 | Q8S929 | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | Cysteine protease ATG4a; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes; Belongs to the peptidase C54 family. | 0.835 |
ATG18A | ATG4B | Q93VB2 | Q9M1Y0 | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | Cysteine protease ATG4b; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes. | 0.789 |
ATG18A | ATG7 | Q93VB2 | Q94CD5 | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing. | 0.937 |
ATG18A | CCME | Q93VB2 | Q96326 | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | Cytochrome c-type biogenesis protein CcmE homolog, mitochondrial; Heme-binding chaperone that may be involved in cytochrome c maturation in mitochondria; Belongs to the CcmE/CycJ family. | 0.786 |
ATG18A | DES1 | Q93VB2 | F4K5T2 | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | Bifunctional cystathionine gamma-lyase/cysteine synthase; Involved in maintaining Cys homeostasis through the desulfuration of L-cysteine. Modulates the generation of the signaling molecule sulfide in plant cytosol. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein. | 0.716 |
ATG3 | ATG10 | Q0WWQ1 | Q8VZ52 | Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] | 0.978 |
ATG3 | ATG18A | Q0WWQ1 | Q93VB2 | Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. | Autophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. | 0.877 |
ATG3 | ATG4A | Q0WWQ1 | Q8S929 | Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. | Cysteine protease ATG4a; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes; Belongs to the peptidase C54 family. | 0.975 |