STRINGSTRING
XI-1 XI-1 B3H6R4_ARATH B3H6R4_ARATH OFP4 OFP4 NAC026 NAC026 LBD18 LBD18 ERF071 ERF071 NAC073 NAC073 MYB32 MYB32 BLH6 BLH6 IRX12 IRX12 LBD30 LBD30 KNAT1 KNAT1 CYP73A5 CYP73A5 ACO4 ACO4 MYB6 MYB6 BEL1 BEL1 MYB7 MYB7 LAC10 LAC10 MYB63 MYB63 MYB52 MYB52 CESA4 CESA4 NAC043 NAC043 NAC104 NAC104 LBD15 LBD15 IRX14 IRX14 MYB86 MYB86 CESA8 CESA8 TCP4 TCP4 ERF105 ERF105 LAC11 LAC11 MYB61 MYB61 WRKY12 WRKY12 MYB85 MYB85 MYB83 MYB83 MYB20 MYB20 NAC030 NAC030 CCOAMT CCOAMT MYB75 MYB75 GAUT12 GAUT12 IRX15-L IRX15-L LOB LOB OFP10 OFP10 KNAT7 KNAT7 E2FC E2FC NAC007 NAC007 MYB54 MYB54 NAC083 NAC083 IRX10 IRX10 RBR1 RBR1 NAC012 NAC012 MYB46 MYB46 CSLA9 CSLA9 NAC066 NAC066 ERF018 ERF018 MYB58 MYB58 REV REV NAC037 NAC037 IRX15 IRX15 MYB42 MYB42 MYB43 MYB43 AtMYB103 AtMYB103 CESA7 CESA7 ERF109 ERF109 MYB4 MYB4 MYB80 MYB80 IRX9 IRX9 ATHB-15 ATHB-15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XI-1Myosin-5; Myosin heavy chain that is required for the cell cycle- regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Contributes to the trafficking of Golgi stacks, mitochondria and peroxisomes. Required for development of pavement cells, trichomes, and stigmatic papillae. (1520 aa)
B3H6R4_ARATHOvate family protein. (183 aa)
OFP4Transcription repressor OFP4; Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors. Forms a transcription repression complex with KNAT7 which regulates secondary cell wall formation. (315 aa)
NAC026NAC domain-containing protein 26; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls. Belongs to the plant vascular related NAC-domain protein family. (394 aa)
LBD18LOB domain-containing protein 18; Involved in the positive regulation of tracheary element (TE) differentiation. Involved in a positive feedback loop that maintains or promotes NAC030/VND7 expression that regulates TE differentiation- related genes. Functions in the initiation and emergence of lateral roots, in conjunction with LBD16, downstream of ARF7 and ARF19. Transcriptional activator that directly regulates EXPA14, a gene encoding a cell wall- loosening factor that promotes lateral root emergence. Activates EXPA14 by directly binding to a specific region of its promoter. Transcri [...] (262 aa)
ERF071Ethylene-responsive transcription factor ERF071; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity); Belongs to the AP2/ERF transcription factor family. ERF subfamily. (171 aa)
NAC073NAC domain-containing protein 73; Transcriptional activator that plays a regulatory role in the development of secondary cell wall fibers. Involved in the regulation of cellulose and hemicellulose biosynthetic genes as well as of genes involved in lignin polymerization and signaling. Is not a direct target of SND1. (305 aa)
MYB32Transcription factor MYB32. (274 aa)
BLH6BEL1-like homeodomain protein 6; Belongs to the TALE/BELL homeobox family. (532 aa)
IRX12Laccase-4; Lignin degradation and detoxification of lignin-derived products (By similarity). Required for secondary xylem cell wall lignification; Belongs to the multicopper oxidase family. (558 aa)
LBD30LOB domain-containing protein 30; Involved in the positive regulation of tracheary element (TE) differentiation. Involved in a positive feedback loop that maintains or promotes NAC030/VND7 expression that regulates TE differentiation- related genes; Belongs to the LOB domain-containing protein family. (228 aa)
KNAT1Homeobox protein knotted-1-like 1; May play a role in meristem function, and may be involved in maintaining cells in an undifferentiated, meristematic state, and its expression disappears at the same time the shoot apex undergoes the transition from vegetative to reproductive development. Positive regulator of LATERAL ORGAN BOUNDARIES (LOB). Probably binds to the DNA sequence 5'-TGAC-3'. Able to traffic from the L1 to the L2/L3 layers of the meristem, presumably through plasmodesmata. Belongs to the TALE/KNOX homeobox family. (398 aa)
CYP73A5Trans-cinnamate 4-monooxygenase; Controls carbon flux to pigments essential for pollination or UV protection, to numerous pytoalexins synthesized by plants when challenged by pathogens, and to lignins. (505 aa)
ACO41-aminocyclopropane-1-carboxylate oxidase 4; Enzyme involved in the ethylene biosynthesis. May promote stem elongation by maximizing the extensibility cells, possibly by activating ethylene biosynthesis, in response to very-long-chain fatty acids (VLCFAs C20:0 to C30:0); Belongs to the iron/ascorbate-dependent oxidoreductase family. (323 aa)
MYB6Transcription repressor MYB6. (236 aa)
BEL1Homeobox protein BEL1 homolog; Plays a major role in ovule patterning and in determination of integument identity via its interaction with MADS-box factors. Formation of complex with AG-SEP dimers negatively regulates the carpel identity process and favors the maintenance of ovule identity. BEL1-STM complex maintains the indeterminacy of the inflorescence meristem. Required, with SPL, for cytokinin-induced PIN1 expression in ovules. (611 aa)
MYB7Transcription factor MYB7; Transcription factor involved in the negative regulation of flavonol biosynthesis. Represses the early phenylpropanoid genes, phenylalanine ammonia-lyase (PAL), cinnamate 4-hydroxylase (C4H) and 4- coumarate-CoA ligase (4CL), as well as the flavonoid-specific genes, flavonoid 3'-hydroxylase (F3'H) and dihydroflavonol 4-reductase (DFR). Plays a role in seed germination inhibition. Negatively regulates the expression of the abscisic acid (ABA) signaling transcription factor ABI5 in seeds. (269 aa)
LAC10Laccase-10; Lignin degradation and detoxification of lignin-derived products. (558 aa)
MYB63Transcription factor MYB63; Transcriptional activator that binds DNA to the AC cis- elements 5'-ACCTACC-3', 5'-ACCAACC-3' and 5'-ACCTAAC-3' of promoters and specifically activates lignin biosynthetic genes during secondary wall formation mediated by SND1. (294 aa)
MYB52Transcription factor MYB52; Transcription factor that confers sensitivity to abscisic acid (ABA) and salt, but tolerance to drought. Regulates secondary cell wall (SCW) biosynthesis, especially in interfascicular and xylary fibers. (249 aa)
CESA4Cellulose synthase A catalytic subunit 4 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening. (1049 aa)
NAC043NAC domain-containing protein 43; Transcription activator of genes involved in biosynthesis of secondary walls. Together with NST2 and NST3, required for the secondary cell wall thickening of sclerenchymatous fibers, secondary xylem (tracheary elements), and of the anther endocethium, which is necessary for anther dehiscence. May also regulate the secondary cell wall lignification of other tissues. (365 aa)
NAC104NAC domain-containing protein 104; Probable transcription factor that influences tracheary elements and xylem development by negatively regulating secondary cell wall fiber synthesis and programmed cell death. (187 aa)
LBD15LOB domain-containing protein 15; Belongs to the LOB domain-containing protein family. (224 aa)
IRX14Beta-1,4-xylosyltransferase IRX14; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Involved in the elongation of glucuronoxylan xylosyl backbone. Xylan xylosyltransferase that acts cooperatively with IRX9 to achieve the successive addition of xylosyl residues during xylan backbone elongation. Required for the proper composition and structural properties of released seed coat mucilage. Required for the production of highly branched xylan polymers in seed coat mucilage. Xylan with xylose side chains seems to be necessary for pecti [...] (525 aa)
MYB86Transcription factor MYB86; Probable transcription factor. (352 aa)
CESA8Cellulose synthase A catalytic subunit 8 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening. (985 aa)
TCP4Transcription factor TCP4; Transcription factor playing a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Required during early steps of embryogenesis. Participates in ovule develpment. Activates LOX2 expression by binding to the 5'-GGACCA-3' motif found in its promoter. (420 aa)
ERF105Ethylene-responsive transcription factor ERF105; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity); Belongs to the AP2/ERF transcription factor family. ERF subfamily. (221 aa)
LAC11Laccase-11; Lignin degradation and detoxification of lignin-derived products. (557 aa)
MYB61Transcription factor MYB61; Transcription factor that coordinates a small network of downstream target genes required for several aspects of plant growth and development, such as xylem formation and xylem cell differentiation, and lateral root formation. Regulates a specific set of target genes by binding DNA to the AC cis- element 5'-ACCTAC-3'. Functions as a transcriptional regulator of stomatal closure. Plays a role the regulation of stomatal pore size independently of abscisic acid (ABA). Required for seed coat mucilage deposition during the development of the seed coat epidermis. [...] (366 aa)
WRKY12Probable WRKY transcription factor 12; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-c family. (218 aa)
MYB85Myb family transcription factor. (266 aa)
MYB83Transcription factor MYB83; Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1 and its close homologs, including NAC043/NST1, NAC066/NST2, NAC101/VND6 and NAC030/VND7. Is required for functional expression of a number of secondary wall-associated transcription factors and secondary wall biosynthetic genes involved in cellulose, xylan and lignin synthesis. Functions redundantly with MYB46 in the transcriptional regulatory cascade leading to secondary wall form [...] (343 aa)
MYB20Transcription factor MYB20; Transcription factor that acts as positive regulator of abscisic acid (ABA) signaling in response to salt stress. Acts as negative regulator ABI1, ABI2 and PP2CA, which are protein phosphatases 2C acting as negative regulator of ABA signaling. Binds to the DNA specific sequence and core element 5'-ACGT-3' found in the promoters of ABI1 and PP2CA to negatively regulate their expression during ABA- dependent salt stress response. (282 aa)
NAC030NAC domain-containing protein 30; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating protoxylem vessel differentiation by promoting immature xylem vessel-specific genes expression. Can activate the expression of several genes including XCP1, MYB46, NAC010/SND3, MYB10 [...] (324 aa)
CCOAMTPutative caffeoyl-CoA O-methyltransferase At1g67980; Methylates caffeoyl-CoA to feruloyl-CoA and 5- hydroxyferuloyl-CoA to sinapoyl-CoA. Plays a role in the synthesis of feruloylated polysaccharides. Involved in the reinforcement of the plant cell wall. Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers (By similarity). (232 aa)
MYB75Transcription factor MYB75; Transcription activator, when associated with BHLH12/MYC1, EGL3, or GL3. Promotes the synthesis of. phenylpropanoid-derived compounds such as anthocyanins and proanthocyanidin, probably together with GL3 and BHLH2. Regulates the expression of CHS, DFRA, LDOX, and BAN. (248 aa)
GAUT12Probable galacturonosyltransferase 12; Involved in pectin assembly and/or distribution, and in the synthesis of secondary wall glucuronoxylan. Probably involved in the synthesis of the glycosyl sequence at the glucuronoxylan reducing end. May be involved in synthesis of a complex glycan primer for xylan synthesis. (535 aa)
IRX15-LProtein IRX15-LIKE; Required for xylan biosynthesis, but not directly involved in catalyzing the addition of sugars to the growing polymer. (317 aa)
LOBProtein LATERAL ORGAN BOUNDARIES; Not known; ectopic expression of LOB leads to alterations in the size and shape of leaves and floral organs and causes male and female sterility; Belongs to the LOB domain-containing protein family. (186 aa)
OFP10Transcription repressor OFP10; Transcriptional repressor that may regulate multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors. (196 aa)
KNAT7Homeobox protein knotted-1-like 7; May be involved in secondary cell wall biosynthesis. (291 aa)
E2FCTranscription factor E2FC; Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation- dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. Belongs to the E2F/DP family. (396 aa)
NAC007NAC domain-containing protein 7; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls. (395 aa)
MYB54Transcription factor MYB54; Transcription factor that regulates secondary cell wall (SCW) biosynthesis, especially in interfascicular and xylary fibers. (243 aa)
NAC083NAC domain-containing protein 83; Transcriptional repressor that negatively regulates the expression of genes involved in xylem vessel formation. Represses the transcriptional activation activity of NAC030/VND7, which regulates protoxylem vessel differentiation by promoting immature xylem vessel- specific genes expression. Transcriptional activator that regulates the COLD-REGULATED (COR15A and COR15B) and RESPONSIVE TO DEHYDRATION (LTI78/RD29A and LTI65/RD29B) genes by binding directly to their promoters. Mediates signaling crosstalk between salt stress response and leaf aging process. [...] (252 aa)
IRX10Probable beta-1,4-xylosyltransferase IRX10; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Probably involved in the elongation of glucuronoxylan xylosyl backbone, especially in the formation of GlcUA side chain of xylans. (412 aa)
RBR1Retinoblastoma-related protein 1; Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate. Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation. Plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate m [...] (1013 aa)
NAC012NAC domain-containing protein 12; Transcriptional activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening and lignification of sclerenchymatous fibers and secondary xylem vessels (tracheary elements). Seems to repress the secondary cell wall thickening of xylary fibers. May also regulate the secondary cell wall lignification of other tissues. Binds to and activates the promoter of MYB46. (358 aa)
MYB46Transcription factor MYB46; Transcription activator. Involved in the regulation of secondary wall biosynthesis in fibers and vessels. Transcription activator of the mannan synthase CSLA9 that recognizes and binds to the DNA consensus sequence 5'-[AG][GT]T[AT]GGT[GA]-3' cis- regulatory element of CSLA9 promoter. Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis. Is directly activated by NAC012/SND1. Functions redundantly with MYB83 in the transcriptional regulatory cascade leading to secondary wa [...] (280 aa)
CSLA9Glucomannan 4-beta-mannosyltransferase 9; Possesses glucomannan synthase and mannan synthase activities in vitro. Mannan synthase consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall. Required for lateral root development. (533 aa)
NAC066NAC domain-containing protein 66; Transcription activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening of the anther endocethium, which is necessary for anther dehiscence. May also regulate the secondary cell wall lignification of other tissues such as tracheary elements. (334 aa)
ERF018Ethylene-responsive transcription factor ERF018; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity); Belongs to the AP2/ERF transcription factor family. ERF subfamily. (195 aa)
MYB58Transcription factor MYB58; Transcriptional activator that binds DNA to the AC cis- elements 5'-ACCTACC-3', 5'-ACCAACC-3' and 5'-ACCTAAC-3' of promoters and specifically activates lignin biosynthetic genes during secondary wall formation mediated by SND1. (274 aa)
REVHomeobox-leucine zipper protein REVOLUTA; Probable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity. Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4. Required to regulate adaxial-abaxial polarity and leaf axial patterning. (842 aa)
NAC037NAC domain-containing protein 37; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls. (365 aa)
IRX15Protein IRREGULAR XYLEM 15; Required for xylan biosynthesis, but not directly involved in catalyzing the addition of sugars to the growing polymer. (322 aa)
MYB42Putative transcription factor. (286 aa)
MYB43Putative transcription factor. (327 aa)
AtMYB103Putative MYB family transcription factor; 19087-20744. (370 aa)
CESA7Cellulose synthase A catalytic subunit 7 [UDP-forming]; Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the secondary cell wall formation. Required for the xylem cell wall thickening. Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. (1026 aa)
ERF109Ethylene-responsive transcription factor ERF109; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). (268 aa)
MYB4Transcription repressor MYB4; Transcription repressor involved in regulation of protection against UV. Mediates transcriptional repression of CYP73A5, the gene encoding trans-cinnamate 4-monooxygenase, thereby regulating the accumulation of the UV-protectant compound sinapoylmalate. (282 aa)
MYB80Transcription factor MYB80; Transcription factor that binds to the DNA sequence 5'- CCAACC-3'. Regulates directly PME5, UND and GLOX1. Essential for tapetum development in anthers and microsporogenesis. Regulates the timing of tapetal programmed cell death (PCD) which is critical for pollen development. May act through the activation of UND, encoding an A1 aspartic protease. Required for anther development by regulating tapetum development, callose dissolution and exine formation. Acts upstream of A6 and FAR2/MS2, two genes required for pollen exine formation. Negatively regulates tric [...] (320 aa)
IRX9Beta-1,4-xylosyltransferase IRX9; Involved in the synthesis of the hemicellulose glucuronoxylan, a major component of secondary cell walls. Xylan xylosyltransferase that acts cooperatively with IRX14 to achieve the successive addition of xylosyl residues during xylan backbone elongation. (351 aa)
ATHB-15Homeobox-leucine zipper protein ATHB-15; Probable transcription factor involved in the regulation of meristem development to promote lateral organ formation. May regulates procambial and vascular tissue formation or maintenance, and vascular development in inflorescence stems; Belongs to the HD-ZIP homeobox family. Class III subfamily. (836 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.