STRINGSTRING
SIRK SIRK NAC002 NAC002 MPK3 MPK3 MPK4 MPK4 MPK6 MPK6 WAK1 WAK1 UBQ14 UBQ14 BSMT1 BSMT1 K15N18.17 K15N18.17 WRKY38 WRKY38 UBQ10 UBQ10 NAC072 NAC072 F24G16.200 F24G16.200 NAC081 NAC081 NAC019 NAC019 SARD1 SARD1 WRKY8 WRKY8 NTF2 NTF2 MRH10.6 MRH10.6 NIMIN-1 NIMIN-1 NAC055 NAC055 MPK11 MPK11 PAD4 PAD4 ICS1 ICS1 WRKY40 WRKY40 AZI1 AZI1 EDS1 EDS1 WRKY29 WRKY29 F22D22.11 F22D22.11 CBP60G CBP60G NAC098 NAC098 MYB51 MYB51 NPR1 NPR1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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SIRKSenescence-induced receptor-like serine/threonine-protein kinase; Involved in innate immune response of plants. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (876 aa)
NAC002NAC domain-containing protein 2. (289 aa)
MPK3Mitogen-activated protein kinase 3; Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Mediates the phosphorylation of VIP1 and subsequent stress genes transcription in response to Agrobacterium. MKK9-M [...] (370 aa)
MPK4Mitogen-activated protein kinase 4; The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. Essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during male-specific meiosis. Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65- 1. Involved in root hair development process. Negative regulator of systemic acquired resistance (SAR) and salicylic acid- (SA) mediated defense response. Requi [...] (376 aa)
MPK6Mitogen-activated protein kinase 6; Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Phosphorylates 1-aminocyclopropane-1- carboxylic acid synthases (ACS2 and ACS6) and may be involved in the regulati [...] (395 aa)
WAK1Wall-associated receptor kinase 1; Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development. Required during plant's response to pathogen infection and in plant defense against heavy metal toxicity. Phosphorylates the oxygen-evolving enhancer protein 2 (OEE2) in an GRP-3-dependent manner. (735 aa)
UBQ14Polyubiquitin 14; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasm [...] (305 aa)
BSMT1Salicylate/benzoate carboxyl methyltransferase; Methyltransferase involved in the biosynthesis of methylsalicylate in response to stresses. Utilizes salicylic acid (SA) more efficiently than benzoic acid (BA). Can also use anthranilic acid and m-hydroxybenzoic acid as substrate. (379 aa)
K15N18.17Putative NTF2-containing RNA-binding protein. (458 aa)
WRKY38Probable WRKY transcription factor 38; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). (289 aa)
UBQ10Polyubiquitin 10; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasm [...] (457 aa)
NAC072NAC domain-containing protein 72; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (297 aa)
F24G16.200Defensin-like protein 206. (80 aa)
NAC081Protein ATAF2; Involved in disease resistance response. May function as repressor of pathogenesis-related proteins. May function in the regulation of host basal defense responses against viral infection. Transcriptional activator involved in responses to wounding and infection with tobamovirus (TMV). Binds to the DNA sequences 5'-AAAATATCT-3' and 5'AGATTTTT-3' of CYP734A1/BAS1 and CYP72C1/SOB7 promoters, respectively. Acts as suppressor of the brassinosteroid (BR)-inactivating enzymes CYP734A1/BAS1 and CYP72C1/SOB7, and prevents their expression in almost all tissues. Plays a central r [...] (283 aa)
NAC019NAC domain-containing protein 19; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
SARD1Protein SAR DEFICIENT 1; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P. syringae pv. maculicola and Hyaloperonospora arabidopsidis. Belongs to the plant ACBP60 prote [...] (451 aa)
WRKY8WRKY transcription factor 8; Transcription factor. Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring stress-responsive cis-acting element. Functions as positive regulator of salt stress response. Binds the W box of LTI78/RD29A stress-response gene and directly regulates its transcription under salt stress. Functions antagonistically with VQ9 to regulate sodium and potassium homeostasis under salt stress by regulating the expression of downstream SOS (SALT OVERLY SENSITIVE) stress-responsive genes. The DNA-binding activity of WRKY8 is decreased by VQ9. Func [...] (326 aa)
NTF2Nuclear transport factor 2; Involved in RNA-directed DNA methylation (RdDM). (460 aa)
MRH10.6Gb|AAD20086.1. (450 aa)
NIMIN-1Protein NIM1-INTERACTING 1; Belongs to the NPR1-interactor family. (142 aa)
NAC055NAC domain-containing protein 55; Transcription factors that bind specifically to the 5'- CATGTG-3' motif. (317 aa)
MPK11Mitogen-activated protein kinase 11. (369 aa)
PAD4Lipase-like PAD4; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe- associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS-LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response to the fungal toxin fumo [...] (541 aa)
ICS1Isochorismate synthase 1, chloroplastic; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity. (569 aa)
WRKY40Probable WRKY transcription factor 40; Transcription factor (By similarity). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element (By similarity). (302 aa)
AZI1pEARLI1-like lipid transfer protein 1; Probable lipid transfer protein (LTP). Seems to control the flowering process and lignin synthesis. Together with DIR1, required for glycerol-3-phosphate- (G3P) and azelaic acid- (AA) induced systemic acquired resistance (SAR). Component of plant systemic immunity involved in priming defenses in a AA-dependent manner, by modulating production and/or translocation of a mobile signal(s) during SAR. Confers resistance to Botrytis cinerea and Pseudomonas syringae pv. tomato DC3000 and PmaDG3. May be involved in induced systemic resistance (ISR) mediat [...] (161 aa)
EDS1Protein EDS1; Positive regulator of basal resistance and of effector- triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation. Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling. Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid. Nuclear localization is essential for bas [...] (623 aa)
WRKY29Probable WRKY transcription factor 29; Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element. Activates WRKY 22, SIRK and its own promoters; Belongs to the WRKY group II-e family. (304 aa)
F22D22.11Transmembrane receptor. (353 aa)
CBP60GCalmodulin-binding protein 60 G; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1, PR2 and EDS5) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326, P. syringae pv. tomato DC3000, and microbe- associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e.g. UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis. Involved in b [...] (563 aa)
NAC098Protein CUP-SHAPED COTYLEDON 2; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of [...] (375 aa)
MYB51Transcription factor MYB51; Transcription factor positively regulating indolic glucosinolate biosynthetic pathway genes. (352 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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