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CSY5 CSY5 F28J12.100 F28J12.100 GK3 GK3 SAMDC1 SAMDC1 PURA PURA dl4945w dl4945w GLN1-4 GLN1-4 HXK3 HXK3 GNA1 GNA1 TOM40-1 TOM40-1 PHS1-3 PHS1-3 GFAT GFAT HKL1 HKL1 SAMDC3 SAMDC3 GLN1-3 GLN1-3 CSY2 CSY2 CSY1 CSY1 GK-2 GK-2 WIN1 WIN1 SAMDC2 SAMDC2 NAGK NAGK PGMP PGMP PHS2 PHS2 PGM2 PGM2 CSY3 CSY3 HKL3 HKL3 ADK ADK A0A1P8ARU2 A0A1P8ARU2 PGM3 PGM3 CSY4 CSY4 IMPDH IMPDH OASA1 OASA1 DRT101 DRT101 GK-1 GK-1 HXK2 HXK2 T25N20.10 T25N20.10 SAMDC4 SAMDC4 HXK1 HXK1 GLN2 GLN2 GLN1-1 GLN1-1 ATHXK4 ATHXK4 F15C21.8 F15C21.8 GLN1-5 GLN1-5 GLN1-2 GLN1-2 MAPDA MAPDA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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CSY5Citrate synthase 5, mitochondrial; Belongs to the citrate synthase family. (464 aa)
F28J12.100Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (536 aa)
GK3Guanylate kinase 3, chloroplastic; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family. (282 aa)
SAMDC1S-adenosylmethionine decarboxylase 1 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development; Belongs to the eukaryotic AdoMetDC family. (366 aa)
PURAAdenylosuccinate synthetase, chloroplastic; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (490 aa)
dl4945wAcetylornithine deacetylase. (440 aa)
GLN1-4Glutamine synthetase cytosolic isozyme 1-4; High-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
GNA1Glucosamine 6-phosphate N-acetyltransferase; Acetyltransferase involved in UDP-N-acetylglucosamine (UDP- GlcNAc) biosynthesis. UDP-GlcNAc is an essential metabolite that serves as an initial sugar donor for N-glycan synthesis and thus plays an important role in protein and lipid glycosylation. (149 aa)
TOM40-1Mitochondrial import receptor subunit TOM40-1, N-terminally processed; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Directly involved in the pore formation; Belongs to the Tom40 family. (309 aa)
PHS1-3Alpha-glucan phosphorylase 1; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). May be not required for the degradation of starch, but the phosphorolysis of starch may play an important role in water stress tolerance. (962 aa)
GFATPutative glucosamine-fructose-6-phosphate aminotransferase. (677 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
SAMDC3S-adenosylmethionine decarboxylase 1 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development. (349 aa)
GLN1-3Glutamine synthetase cytosolic isozyme 1-3; Low-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (354 aa)
CSY2Citrate synthase 2, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (514 aa)
CSY1Citrate synthase 1, peroxisomal; Belongs to the citrate synthase family. (480 aa)
GK-2Guanylate kinase 2; Essential for recycling GMP and indirectly, cGMP. Required for normal development of the gametophyte and embryo, in association with GK1. (389 aa)
WIN1Acetylornithine aminotransferase, chloroplastic/mitochondrial; Involved in the biosynthesis of citrulline (By similarity). Essential gene that modulates defense response to pathogenic bacteria, conferring susceptibility and repressing salicylic acid (SA) accumulation; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
SAMDC2S-adenosylmethionine decarboxylase 2 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development; Belongs to the eukaryotic AdoMetDC family. (362 aa)
NAGKAcetylglutamate kinase, chloroplastic; Involved in the arginine biosynthetic pathway via the intermediate compound ornithine; Belongs to the acetylglutamate kinase family. ArgB subfamily. (347 aa)
PGMPPhosphoglucomutase, chloroplastic; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (623 aa)
PHS2Alpha-glucan phosphorylase 2, cytosolic; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (841 aa)
PGM2Probable phosphoglucomutase, cytoplasmic 2; This enzyme participates in both the breakdown and synthesis of glucose. (585 aa)
CSY3Citrate synthase 3, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (509 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
ADKAdenylate kinase 1, chloroplastic; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis, adenine nucleotide metabolism and plant growth. Belongs to the adenylate kinase family. (284 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
PGM3Probable phosphoglucomutase, cytoplasmic 1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (583 aa)
CSY4Citrate synthase 4, mitochondrial; Belongs to the citrate synthase family. (474 aa)
IMPDHInosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (503 aa)
OASA1Cysteine synthase 1; Acts as a major cysteine synthase, probably involved in maintaining organic sulfur level; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
DRT101Phosphoacetylglucosamine mutase; Interconverts GlcNAc-6-P and GlcNAc-1-P; Belongs to the phosphohexose mutase family. (556 aa)
GK-1Guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP. Required for normal development of the gametophyte and embryo, in association with GK2. (387 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
T25N20.10Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein. (205 aa)
SAMDC4S-adenosylmethionine decarboxylase 1 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development. (347 aa)
HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
GLN2Glutamine synthetase, chloroplastic/mitochondrial; The light-modulated chloroplast/mitochondrial enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration. Belongs to the glutamine synthetase family. (430 aa)
GLN1-1Glutamine synthetase cytosolic isozyme 1-1; High-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
F15C21.8Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (527 aa)
GLN1-5Glutamine synthetase cytosolic isozyme 1-5; Belongs to the glutamine synthetase family. (353 aa)
GLN1-2Glutamine synthetase cytosolic isozyme 1-2; Low-affinity glutamine synthetase. May contribute to the homeostatic control of glutamine synthesis in roots. (356 aa)
MAPDAN6-mAMP deaminase; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A). Does not possess deaminase activity toward adenosine, AMP, N6-methyladenosine, or N6-mATP in vitro. (355 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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