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BHLH47 BHLH47 FRO3 FRO3 F4JUZ6_ARATH F4JUZ6_ARATH NAS3 NAS3 IRT2 IRT2 FIT FIT IRT1 IRT1 FER1 FER1 PHL1 PHL1 BHLH104 BHLH104 SPX1 SPX1 FRO6 FRO6 PHO1 PHO1 NAS4 NAS4 NAS1 NAS1 NAS2 NAS2 S8H S8H F6'H1 F6'H1 BHLH32 BHLH32 BHLH34 BHLH34 ORG2 ORG2 CYP82C4 CYP82C4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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BHLH47Transcription factor bHLH47. (240 aa)
FRO3Ferric reduction oxidase 3, mitochondrial; Ferric chelate reductase involved in iron reduction in roots. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. (717 aa)
F4JUZ6_ARATHNicotianamine synthase. (84 aa)
NAS3Nicotianamine synthase 3; Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron; Belongs to the nicotianamine synthase (NAS)-like family. (320 aa)
IRT2Fe(2+) transport protein 2; High-affinity iron transporter that mediates under iron- deficiency the iron uptake from the rhizosphere across the plasma membrane in the root epidermal layer. Could also be capable of transporting zinc ions; Belongs to the ZIP transporter (TC 2.A.5) family. (350 aa)
FITTranscription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR; Transcription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. (318 aa)
IRT1Fe(2+) transport protein 1; High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions; Belongs to the ZIP transporter (TC 2.A.5) family. (347 aa)
FER1Ferritin-1, chloroplastic; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). (255 aa)
PHL1Protein PHR1-LIKE 1; Transcription factor acting as central integrator of phosphate starvation responses. Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis ; Belongs to the MYB-CC family. (413 aa)
BHLH104Transcription factor bHLH104. (283 aa)
SPX1SPX domain-containing protein 1; Plays a positive role in plant adaptation to phosphate starvation. Inhibits PHR1 DNA-binding activity in a Pi-dependent manner. (256 aa)
FRO6Ferric reduction oxidase 6; Ferric chelate reductase involved in iron uptake by shoot and leaf cells. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. (738 aa)
PHO1Phosphate transporter PHO1; Inositol polyphosphate sensor that associates with transcription factors to regulate inorganic phosphate (Pi) starvation responses. Probably acts by binding inositol polyphosphate via its SPX domain. Acts as a Pi exporter, mediating efflux of Pi out of cells. Transfers Pi from the epidermal and cortical cells to the root xylem vessels. Involved in the transfer of Pi from roots to shoots. Involved in abscisic acid (ABA) induction of stomatal closure and ABA repression of stomatal opening. Belongs to the SYG1 (TC 2.A.94) family. (782 aa)
NAS4Probable nicotianamine synthase 4; Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron; Belongs to the nicotianamine synthase (NAS)-like family. (324 aa)
NAS1Nicotianamine synthase 1; Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron; Belongs to the nicotianamine synthase (NAS)-like family. (320 aa)
NAS2Nicotianamine synthase 2; Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron; Belongs to the nicotianamine synthase (NAS)-like family. (320 aa)
S8HScopoletin 8-hydroxylase; Involved in the pathway of sideretin biosynthesis from feruloyl CoA, a redox-active catecholic metabolite exuded by roots in response to iron deficiency in order to facilitate the uptake of iron; this pathway consists in the successive conversion from feruloyl CoA to scopoletin, from scopoletin to fraxetin and from fraxetin to sideretin. Catalyzes the biosynthesis of fraxetin via scopoletin hydroxylation. Belongs to the iron/ascorbate-dependent oxidoreductase family. (357 aa)
F6'H1Feruloyl CoA ortho-hydroxylase 1; 2-oxoglutarate (OG)- and Fe(II)-dependent dioxygenase (2OGD) involved in scopoletin biosynthesis. Converts feruloyl CoA into 6'-hydroxyferuloyl CoA but has no activity with ferulic acid, feruloylquinic acid, caffeic acid, caffeoyl CoA, p- coumaric acid, cinnamic acid, cinnamoyl CoA or benzoyl CoA. Required for the production and secretion of compounds (e.g. fluorescent coumarins) that facilitate the mobilization and uptake of iron from sources with low bioavailability or in high pH- induced iron deficiency conditions. Involved in the pathway of sideret [...] (361 aa)
BHLH32Transcription factor AIG1; Transcription factor required for MONOPTEROS-dependent root initiation in embryo. Transcriptionally controlled by MONOPTEROS. (344 aa)
BHLH34Transcription factor bHLH34. (320 aa)
ORG2Transcription factor ORG2. (253 aa)
CYP82C4Xanthotoxin 5-hydroxylase CYP82C4; Can hydroxylate xanthotoxin (8-methoxypsoralen) to form 5- hydroxyxanthotoxin (5-hydroxy-8-methoxypsoralen) in vivo and in vitro. Involved in the early iron deficiency response, possibly through an IDE1-like mediated pathway. Involved in the pathway of sideretin biosynthesis from feruloyl CoA, a redox-active catecholic metabolite exuded by roots in response to iron deficiency in order to facilitate the uptake of iron; this pathway consists in the successive conversion from feruloyl CoA to scopoletin, from scopoletin to fraxetin and from fraxetin to si [...] (524 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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