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LNK1 LNK1 B3H7M7_ARATH B3H7M7_ARATH LNK2 LNK2 ELF4 ELF4 HDA19 HDA19 ATXR3 ATXR3 SNL3 SNL3 ELF3 ELF3 LHCB1.1 LHCB1.1 EIF4A1 EIF4A1 CCA1 CCA1 APRR5 APRR5 TAF1B TAF1B RVE4 RVE4 LHY LHY HDA9 HDA9 APRR9 APRR9 AFR AFR JMJ30 JMJ30 RVE8 RVE8 APRR7 APRR7 TPL TPL IDD14 IDD14 HDA7 HDA7 HDA6 HDA6 CYP705A18 CYP705A18 APRR1 APRR1 AGL18 AGL18 LUX LUX SNL1 SNL1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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LNK1Protein LNK1; Transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1. Antagonizes REV8 function in the regulation of anthocyanin accumulation. Involved in red light input to the clock. Activates clock-controlled genes with afternoon peak. Mediates light inhibition of hypocotyl elongation. (616 aa)
B3H7M7_ARATHCorepressor. (170 aa)
LNK2Protein LNK2; Transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1. Antagonizes REV8 function in the regulation of anthocyanin accumulation. Involved in red light input to the clock. Activates clock-controlled genes with afternoon peak. Mediates light inhibition of hypocotyl elongation. Unable to bind to DNA, but recruited to the evening element (EE)-containing region of the PRR5 and TOC1 promoters through its interaction with the DNA binding proteins REV8 and REV4. (663 aa)
ELF4Protein EARLY FLOWERING 4; Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. Increases ELF3 nuclear distribution and localization in nuclear bodies. Required for responsiveness to continuous red, by regulating phytochrome B (phyB) signaling (including during seedling de-etiolation) and gene expression. Mediates both entrainment to an env [...] (111 aa)
HDA19Histone deacetylase 19; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous flora [...] (501 aa)
ATXR3Histone-lysine N-methyltransferase ATXR3; Histone methyltransferase specifically required for trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development. (2335 aa)
SNL3Paired amphipathic helix protein Sin3-like 3; Acts as a transcriptional repressor. Interacts with ERF7 to repress genes in abscisic acid and drought stress responses. The heterodimer represses transcription by tethering SNL3 to DNA. (1330 aa)
ELF3Protein EARLY FLOWERING 3; May be a transcription factor part of a circadian clock input pathway. Acts within a 'zeitnehmer' feedback loop and is involved in its own circadian regulation. Has no role in regulating circadian clock function in the dark. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. The activity of the protein may be decreased in long day conditions due to its interaction with phytochrome B (phyB). Can regulate the initiation of flowering independently of phyB. Also involved in responses to nematode pa [...] (695 aa)
LHCB1.1Chlorophyll a-b binding protein 2, chloroplastic; The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated; Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family. (267 aa)
EIF4A1Eukaryotic initiation factor 4A-1; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily. (412 aa)
CCA1Protein CCA1; Transcription factor involved in the circadian clock and in the phytochrome regulation. Binds to the promoter regions of APRR1/TOC1 and TCP21/CHE to repress their transcription. Binds to the promoter regions of CAB2A and CAB2B to promote their transcription. Represses both LHY and itself. (608 aa)
APRR5Two-component response regulator-like APRR5; Transcriptional repressor of CCA1 and LHY, thereby controlling photoperiodic flowering response. Involved in the positive and negative feedback loops of the circadian clock. With RVE8, forms a negative feedback loop of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Proteolytic substrate of the E3 ubiquitin ligase SCF(ADO1) complex. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particula [...] (558 aa)
TAF1BTranscription initiation factor TFIID subunit 1b; TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Core scaffold of the TFIID complex. Acts as a histone acetyltransferase involved in the light regulation of growth and gene expression. Required for H3K9, H3K27, and H4K12 acetylation on the target promoters. (1786 aa)
RVE4Protein REVEILLE 4; Probable transcription factor. (293 aa)
LHYProtein LHY; Transcription factor involved in the circadian clock. Binds to the promoter region of APRR1/TOC1 and TCP21/CHE to repress their transcription. Represses both CCA1 and itself. (645 aa)
HDA9Histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (426 aa)
APRR9Two-component response regulator-like APRR9; Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Controls photoperiodic flowering response and temperature compensation. Involved in the positive and negative feedback loops of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Regulated at the transcriptional level by a corepressor complex consisting of ELF4, ELF3, and LUX. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from [...] (468 aa)
AFRF-box protein AFR; Component of SCF (ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyls elongation in response to red and far-red light exposure. (372 aa)
JMJ30Lysine-specific demethylase JMJ30; Histone demethylase that demethylates 'Lys-36' (H3K36me) of histone H3 with a specific activity for H3K36me3 and H3K36me2. No activity on H3K36me1. Involved in the control of flowering time by demethylating H3K36me2 at the FT locus and repressing its expression. Acts within the central clock. Works in concert with TOC1 to promote the morning-phased clock genes CCA1 and LHY which function as components of the central oscillator. (429 aa)
RVE8Protein REVEILLE 8; Transcriptional activator of evening element (EE)-containing clock-controlled genes. Forms a negative feedback loop with APRR5. Regulates the pattern of histone H3 acetylation of the TOC1 promoter. (298 aa)
APRR7Two-component response regulator-like APRR7; Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress. Involved in the positive and negative feedback loops of the circadian clock. Controls photoperiodic flowering response and temperature compensation. Expression of several members of the ARR-like family is controlled by circadian rhythm. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes [...] (727 aa)
TPLProtein TOPLESS; Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes. Required for ovule development. (1131 aa)
IDD14Protein indeterminate-domain 14; Transcription factor regulating starch metabolism by binding directly to the promoter of QQS. The IDD14beta isoform attenuates the transcription factor activity by competitively forming heterodimers with reduced DNA-binding capacity. Regulates lateral organ morphogenesis and gravitropic responses. Has a redundant role with IDD16 in directing leaf and floral organ morphogenesis. Involved in the establishment of auxin gradients through the regulation of auxin biosynthesis and transport. (419 aa)
HDA7Histone deacetylase 7; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. May be involved in flowering induction. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (409 aa)
HDA6Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this e [...] (471 aa)
CYP705A18Cytochrome P450, family 705, subfamily A, polypeptide 18; Belongs to the cytochrome P450 family. (524 aa)
APRR1Two-component response regulator-like APRR1; Controls photoperiodic flowering response. Component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. Positive regulator of CCA1 and LHY expression. (618 aa)
AGL18Agamous-like MADS-box protein AGL18; Probable transcription factor involved in the negative regulation of flowering, probably through the photoperiodic pathway. Prevents premature flowering. Downstream regulator of a subset of the MIKC* MADS-controlled genes required during pollen maturation. (256 aa)
LUXTranscription factor LUX; Transcription factor that is essential for the generation of the circadian clock oscillation. Is necessary for activation of CCA1 and LHY expression. Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter. Directly regulates the expression of PRR9, a major component of the morning transcriptional feedback circuit, by binding specific sites on PRR9 promoter. Binds to its own promoter, inducing a negative auto-regulatory feedback loop within the core clock. Binds to ELF3 a [...] (323 aa)
SNL1Paired amphipathic helix protein Sin3-like 1; Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability. (1372 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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