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MKK5 MKK5 TPX2 TPX2 AIR9 AIR9 ANP1 ANP1 ANP3 ANP3 KIN14C KIN14C NEK5 NEK5 KIN12D KIN12D KIN12C KIN12C MPK3 MPK3 MPK4 MPK4 MPK6 MPK6 AUR2 AUR2 EB1A EB1A TAN TAN MAP65-2 MAP65-2 CLASP CLASP KIN7A KIN7A KIN14F KIN14F VPS52 VPS52 MPK18 MPK18 YDA YDA TON2 TON2 EB1C EB1C MAP65-3 MAP65-3 KIN14E KIN14E EB1B EB1B MAP65-1 MAP65-1 PER60 PER60 ANP2 ANP2 RANGAP1 RANGAP1 NEK6 NEK6 MAP65-4 MAP65-4 AUR1 AUR1 GPT1 GPT1 AAA1 AAA1 SPR1 SPR1
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second shell of interactors
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proteins of unknown 3D structure
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MKK5Mitogen-activated protein kinase kinase 5; Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the [...] (348 aa)
TPX2Protein TPX2; Regulates prospindle assembly during late prophase and at the onset of mitosis, before nuclear envelope breakdown (NEB). Is exported from the nucleus shortly before NEB and organized into two polar crescents. After NEB, is progressively associated with the forming spindle. Probably mediates AUR1 activation and localization to spindle microtubules. Has a microtubule binding capability and is able to trigger microtubule assembly induced by RanGTP in a heterologous system. Not involved in phragmoplast assembly, nuclear envelope reformation, and cortical microtubule assembly [...] (790 aa)
AIR9187-kDa microtubule-associated protein AIR9; Microtubule-associated protein that may be involved in the maturation of cell plates and proper insertion of cross-walls after cytokinesis. (1708 aa)
ANP1Mitogen-activated protein kinase kinase kinase ANP1; May be involved in an oxidative stress-mediated signaling cascade that phosphorylates downstream MAP kinases MPK3 and MPK6. May suppress auxin signaling that promotes cell cycle. Functionally redundant to ANP2 and ANP3 in the positive regulation of cytokinesis. (666 aa)
ANP3Mitogen-activated protein kinase kinase kinase 3; Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule- associated proteins such as MAP65-1; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (651 aa)
KIN14CKinesin-like protein KIN-14C; Kinesin that supports microtubule movement in an ATP- dependent manner and has a minus-end directed polarity. Plays a crucial role in spindle morphogenesis in male meiosis. In mitosis, is required for normal microtubule accumulation at the spindle poles during prophase and may play a role in spindle assembly during prometaphase. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily. (793 aa)
NEK5Serine/threonine-protein kinase Nek5; Involved in epidermal-cell morphogenesis in hypocotyls and roots. May act on the microtubule function. May have a secondary role in trichome branching; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. (956 aa)
KIN12DKinesin-like protein KIN-12D; Involved in the spatial control of cytokinesis by a proper phragmoplast guidance; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily. (2771 aa)
KIN12CKinesin-like protein KIN-12C; Involved in the spatial control of cytokinesis by a proper phragmoplast guidance. Localizes TAN to the cortical division sites (CDS) during cytokinesis via direct binding. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-12 subfamily. (2066 aa)
MPK3Mitogen-activated protein kinase 3; Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Mediates the phosphorylation of VIP1 and subsequent stress genes transcription in response to Agrobacterium. MKK9-M [...] (370 aa)
MPK4Mitogen-activated protein kinase 4; The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. Essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during male-specific meiosis. Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65- 1. Involved in root hair development process. Negative regulator of systemic acquired resistance (SAR) and salicylic acid- (SA) mediated defense response. Requi [...] (376 aa)
MPK6Mitogen-activated protein kinase 6; Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Phosphorylates 1-aminocyclopropane-1- carboxylic acid synthases (ACS2 and ACS6) and may be involved in the regulati [...] (395 aa)
AUR2Serine/threonine-protein kinase Aurora-2; Phosphorylates specifically 'Ser-10' of histone H3 in vitro. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle. Might colocalize with gamma-tubulin and function in microtubule organizing centers (MTOCs). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. (282 aa)
EB1AMicrotubule-associated protein RP/EB family member 1A; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. May be involved in anchoring microtubules to their nucleation sites and/or functioning as a reservoir for distribution to the growing end. In plants, microtubule minus ends are not necessarily severed from the nucleation site and transported to the plus end of a microtubule as part of the recycling process. May play a role in endomembrane organization during polarized growth of plant cells. Interacts with the tobamovirus movement prote [...] (276 aa)
TANProbable microtubule-binding protein TANGLED; Is required for spatial control cell division during plant development. Through an association with microtubules, acts both for the positioning of cytoskeletal arrays that establish planes of cell division during prophase and for spatial guidance of expanding phragmoplasts toward preestablished cortical division sites (CDS) during cytokinesis (By similarity). (444 aa)
MAP65-265-kDa microtubule-associated protein 2; Microtubule-associated protein that stabilize microtubules (MT). Involved in the regulation of MT organization and dynamics. Confers MT resistance to the drug propyzamide and cold conditions. (578 aa)
CLASPCLIP-associated protein; Cortical microtubule plus-end tracking protein required for cell morphogenesis and cell division. Promotes the stabilization of dynamic microtubules during mitosis. Regulates microtubule-cortex attachment, thereby contributing to self-organization of cortical microtubules and subsequent cell shape. Belongs to the CLASP family. (1439 aa)
KIN7AKinesin-like protein KIN-7A; Probable plus end-directed motor protein that functions in the NACK-PQR (ANP1-MKK6-MPK4) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion. Regulates the activity and the localization of ANP1, probably by association through the non-catalytic region of the kinase. Functionally redundant with NACK2 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis. Belongs to the TRA [...] (974 aa)
KIN14FKinesin-like protein KIN-14F; Required for keeping the ATP levels stable and balancing the aerobic respiration pathways during seed germination at low temperature; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily. (1087 aa)
VPS52Vacuolar protein sorting-associated protein 52 A; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (By similarity). Required for pollen tube elongation and other polar growth; Belongs to the VPS52 family. (707 aa)
MPK18Mitogen-activated protein kinase 18; Mitogen-activated protein kinase (MAPK) that is specifically regulated by PHS1 and mediates signaling that regulates cortical microtubule functions, maybe through regulation of microtubule dynamic instability. (615 aa)
YDAMitogen-activated protein kinase kinase kinase YODA; Functions in a MAP kinase cascade that acts as a molecular switch to regulate the first cell fate decisions in the zygote and the early embryo. Promotes elongation of the zygote and development of its basal daughter cell into the extra-embryonic suspensor. In stomatal development, acts downstream of the LRR receptor TMM, but upstream of the MKK4/MKK5-MPK3/MPK6 module to regulate stomatal cell fate before the guard mother cell (GMC) is specified. Plays a central role in both guard cell identity and pattern formation. This MAPK cascade [...] (883 aa)
TON2Probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2; Probable regulatory subunit of type 2A protein phosphatase involved in the control of the dynamic organization of the cortical cytoskeleton. Plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. Required for the reorganization of cortical arrays in response to light. (480 aa)
EB1CMicrotubule-associated protein RP/EB family member 1C; Plant-specific EB1 subtype that functions preferentially at early stages of plant mitosis by regulating spindle positioning and chromosome segregation. Accumulates in the prophase nucleus and is required to maintain spindle bipolarity during premetaphase and/or metaphase and for efficient segregation of chromosomes at anaphase. May play a role in the dynamics of microtubule network in elongating pollen tubes. (329 aa)
MAP65-365-kDa microtubule-associated protein 3; Microtubule-associated protein that plays a critical role in organizing the mitotic microtubule array during both early and late mitosis in all plant organs. Essential for the cytokinesis, especially in roots, by maintaining the integrity of the overlapped microtubules in the phragmoplast. Required during root morphogenesis. Needed for giant cell development during root knot nematode infection, where cytokinesis is initiated but not completed. Belongs to the MAP65/ASE1 family. (707 aa)
KIN14EKinesin-like protein KIN-14E; Minus-end microtubule-dependent motor protein involved in the regulation of cell division and trichome morphogenesis through microtubules bundling. Possesses basal and microtubule-stimulated ATPase activities. Acts as a hub that brings together microtubules and actin filaments to modulate the cytoskeleton during trichome formation and morphogenesis. Could be involved in the negative regulation of root growth. (1260 aa)
EB1BMicrotubule-associated protein RP/EB family member 1B; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. May be involved in anchoring microtubules to their nucleation sites and/or functioning as a reservoir for distribution to the growing end. In plants, microtubule minus ends are not necessarily severed from the nucleation site and transported to the plus end of a microtubule as part of the recycling process. May play a role in endomembrane organization during polarized growth of plant cells. (293 aa)
MAP65-165-kDa microtubule-associated protein 1; Microtubule-associated protein that bundle and stabilize adjacent microtubules (MT) of the cell cortex. Enhances MT nucleation. Can also bind to tubulin dimers and promotes their polymerization. Confers MT resistance to the drug propyzamide and cold conditions. Plays a role in the central spindle at anaphase to early cytokinesis but is not essential at the midline of the phragmoplast at later stages. Represses metaphase spindle organization and the transition to anaphase in dephosphorylated active form. Promotes the formation of a planar network [...] (587 aa)
PER60Peroxidase 60; Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue. (331 aa)
ANP2Mitogen-activated protein kinase kinase kinase 2; Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule- associated proteins such as MAP65-1. (651 aa)
RANGAP1RAN GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Plays a role in spatial signaling during cell division. (535 aa)
NEK6Serine/threonine-protein kinase Nek6; May be involved in plant development processes. (416 aa)
MAP65-465-kDa microtubule-associated protein 4; Microtubule-associated protein involved in mitotic spindle formation; Belongs to the MAP65/ASE1 family. (677 aa)
AUR1Serine/threonine-protein kinase Aurora-1; Phosphorylates specifically 'Ser-10' of histone H3 in vitro and colocalizes with phosphorylated histone H3 during mitosis. Associates with cytoskeletal structures that are necessary for cytokinesis and with the microtubule spindle. Colocalizes also with gamma-tubulin and function in microtubule organizing centers (MTOCs). In contrast with the mammalian B-type Aurora, AUR1 has no kinase activity toward 'Ser-28' of histone H3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. (294 aa)
GPT1Glucose-6-phosphate/phosphate translocator 1, chloroplastic; Glucose 6-phosphate (Glc6P) transporter. Transports also inorganic phosphate, 3-phosphoglycerate, triose phosphates and, to a leser extent, phosphoenolpyruvate. Responsible for the transport of Glc6P into plastids of heterotrophic tissues where it can be used as a carbon source for starch biosynthesis, as substrate for fatty acid biosynthesis or as substrate for NADPH generation via the oxidative pentose phosphate pathway (OPPP). Required for pollen maturation and embryo sac development. (388 aa)
AAA1Katanin p60 ATPase-containing subunit A1; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May be required for reorientation of cortical microtubule arrays during cellular elongation. Failure to correctly orient these arrays drastically compromises fiber length, cell wall thickness and mechanical strength. May also be required for the spatial organization of developmental cues within the root. Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. (523 aa)
SPR1Protein SPIRAL1; Required for directional control of cell elongation. Stabilizes growing ends of cortical microtubules and influences their dynamic properties. Acts redundantly with SP1Ls in maintaining the cortical microtubules organization essential for anisotropic cell growth. Plays a key role in salt stress-induced microtubules disassembly. (119 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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