STRINGSTRING
SRT1 SRT1 HDA19 HDA19 EIN3 EIN3 SNL3 SNL3 ERF3 ERF3 ERF4 ERF4 ETR1 ETR1 CTR1 CTR1 EBF2 EBF2 SRT2 SRT2 HDA6 HDA6 ERF7 ERF7 HAC5 HAC5 ETP1 ETP1 EIN2 EIN2 EBF1 EBF1 EIL1 EIL1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SRT1NAD-dependent protein deacetylase SRT1; NAD-dependent protein deacetylase. Has deacetylase activity towards H3K9Ac. May have a function in the safeguard against genome instabiliy and DNA damage to ensure plant cell growth (By similarity). Belongs to the sirtuin family. Class IV subfamily. (473 aa)
HDA19Histone deacetylase 19; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDA19 is involved in jasmonic acid and ethylene signaling of pathogen response. Part of a repressor complex including APETALA2 (AP2) and TOPLESS (TPL) that control the expression domains of numerous flora [...] (501 aa)
EIN3Protein ETHYLENE INSENSITIVE 3; Probable transcription factor acting as a positive regulator in the ethylene response pathway. Is required for ethylene responsiveness in adult plant tissues. Binds a primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter with consequence to activate the transcription of this gene. (628 aa)
SNL3Paired amphipathic helix protein Sin3-like 3; Acts as a transcriptional repressor. Interacts with ERF7 to repress genes in abscisic acid and drought stress responses. The heterodimer represses transcription by tethering SNL3 to DNA. (1330 aa)
ERF3Ethylene-responsive transcription factor 3; Acts as a transcriptional repressor. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways and could also regulate other AtERFs. (225 aa)
ERF4Ethylene-responsive transcription factor 4; Acts as a transcriptional repressor. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways, and could also regulate other AtERFs. (222 aa)
ETR1Ethylene receptor 1; Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. In the presence of ethylene, the auto-kinase activity of ETR1 is inhibited and the non- phosphorylated kinase domain binds tightly to the corresponding domain of EIN2. (738 aa)
CTR1Serine/threonine-protein kinase CTR1; Acts as a negative regulator in the ethylene response pathway. Phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene. (821 aa)
EBF2EIN3-binding F-box protein 2; Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins. (623 aa)
SRT2NAD-dependent protein deacylase SRT2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues (By similarity). Negatively regulates plant basal defense against plant pathogens, possibly by suppressing salicylic acid biosynthesis. Belongs to the sirtuin family. Class II subfamily. (373 aa)
HDA6Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Might remove acetyl residues only from specific targets, such as rDNA repeats or complex transgenes. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for rRNA gene silencing in nucleolar dominance. Plays a role in transgene silencing, but this e [...] (471 aa)
ERF7Ethylene-responsive transcription factor 7; Involved in the regulation of gene expression by abscisic acid, stress factors and by components of stress signal transduction pathways. Transcription factor that binds to the GCC-box pathogenesis- related promoter element. Part of a transcriptional repressor complex including a histone deacetylase. (244 aa)
HAC5Histone acetyltransferase HAC5; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation. (1670 aa)
ETP1F-box protein ETP1; Negative regulator of EIN2 protein stability. (415 aa)
EIN2Ethylene-insensitive protein 2; Central factor in signaling pathways regulated by ethylene (ET), and involved in various processes including development, plant defense, senescence, nucleotide sugar flux, and tropisms. Necessary for ethylene-mediated gene regulation, and for the induction of some genes by ozone. Acts downstream of ET receptors, and upstream of ethylene regulated transcription factors. Required for cytokinin-mediated processes. Seems to be implicated in cross-talk between ET, jasmonate and other pathways. Probably not involved in iron uptake. Has a short half-life and un [...] (1294 aa)
EBF1EIN3-binding F-box protein 1; Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins. Confers insensitivity to ethylene. (628 aa)
EIL1ETHYLENE INSENSITIVE 3-like 1 protein; Probable transcription factor acting as a positive regulator in the ethylene response pathway. Could bind the primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter. Belongs to the EIN3 family. (584 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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