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RKL1 RKL1 NPC2 NPC2 AHA1 AHA1 SD17 SD17 LYM3 LYM3 PUB23 PUB23 NPC6 NPC6 NPC1 NPC1 LYM1 LYM1 BAK1 BAK1 BIR1 BIR1 IOS1 IOS1 FLS3 FLS3 RLK RLK RBOHD RBOHD SPL11 SPL11 OXI1 OXI1 PUB12 PUB12 PUB22 PUB22 WRKY29 WRKY29 NPC4 NPC4 PUB13 PUB13 SERK4 SERK4 SOBIR1 SOBIR1 LYK2 LYK2 PUB24 PUB24 NPC5 NPC5 FER4 FER4 F13M7.4 F13M7.4 RLP30 RLP30 RALF23 RALF23 BIR2 BIR2 CERK1 CERK1 EFR EFR LYK5 LYK5 LYM2 LYM2 BIK1 BIK1 RLP23 RLP23 SIRK SIRK LYK4 LYK4 DBP DBP
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
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gene co-occurrence
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RKL1Probable inactive receptor kinase At1g48480; Belongs to the protein kinase superfamily. (655 aa)
NPC2Non-specific phospholipase C2. (514 aa)
AHA1ATPase 1, plasma membrane-type; The plasma membrane H(+) ATPase of plants and fungi generates a proton gradient that drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses. Forms a functional cation- translocating unit with CNGC17 that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes. (949 aa)
SD17Receptor-like serine/threonine-protein kinase SD1-7; Involved in the regulation of cellular expansion and differentiation. Mediates subcellular relocalization of PUB9 from nucleus to plasma membrane in a protein-phosphorylation-dependent manner. May be involved in the abscisic acid-mediated signaling pathway, at least during germination. (843 aa)
LYM3LysM domain-containing GPI-anchored protein 3; Required as a cell surface receptor for peptidoglycan (PGN) elicitor signaling leading to innate immunity. Plays an essential role in detecting PGNs and restricting bacterial growth (of Pseudomonas syringae pv. tomato DC3000 for example). (423 aa)
PUB23E3 ubiquitin-protein ligase PUB23; E3 ubiquitin-protein ligase that negatively regulates water stress response. May control in coordination with PUB23 a drought signaling pathway by ubiquitinating cytosolic RPN12a. Acts as negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB22 and PUB24. (411 aa)
NPC6Non-specific phospholipase C6. (520 aa)
NPC1Non-specific phospholipase C1. (533 aa)
LYM1LysM domain-containing GPI-anchored protein 1; Required as a cell surface receptor for peptidoglycan (PGN) elicitor signaling leading to innate immunity. Plays an essential role in detecting PGNs and restricting bacterial growth (of Pseudomonas syringae pv. tomato DC3000 for example). (416 aa)
BAK1BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1; Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Controls the expression of genes associated with innate immunity in the absence of pathogens or elicitors. Involved in brassinosteroid (BR) signal transduction. Phosphorylates BRI1. May be involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1- BAK1 heterodimers. Interaction with MSBP1 stimulates the endocytosis of BAK1 and suppresses brassinosteroid signaling. Acts in pathogen- associ [...] (615 aa)
BIR1Probably inactive leucine-rich repeat receptor-like protein kinase At5g48380. (620 aa)
IOS1LRR receptor-like serine/threonine-protein kinase IOS1; Regulates negatively the abscisic acid (ABA) signaling pathway. Required for full susceptibility to filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, probably by triggering the repression of ABA-sensitive COLD REGULATED and RESISTANCE TO DESICCATION genes during infection, but independently of immune responses. Involved in BAK1- dependent and BAK1-independent microbe-associated molecular patterns (MAMPs)-triggered immunity (PTI) leading to defense responses, [...] (894 aa)
FLS3Flavonol synthase 3; Catalyzes the formation of flavonols from dihydroflavonols. Possesses low activity in vitro towards dihydrokaempferol and dihydroquercetin producing kaempferol and quercitin, respectively. Belongs to the iron/ascorbate-dependent oxidoreductase family. (308 aa)
RLKLeucine-rich repeat receptor-like protein kinase. (751 aa)
RBOHDRespiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family. (921 aa)
SPL11Squamosa promoter-binding-like protein 11; Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'. (393 aa)
OXI1Serine/threonine-protein kinase OXI1; Involved in oxidative burst-mediated signaling. Required for basal resistance to P.parasitica infection and root hair growth. Partly required for the activation of MPK3 and MPK6 by hydrogen peroxide and cellulase elicitor. (421 aa)
PUB12U-box domain-containing protein 12; Functions as an E3 ubiquitin ligase. (654 aa)
PUB22E3 ubiquitin-protein ligase PUB22; E3 ubiquitin-protein ligase that negatively regulates water stress response. May control in coordination with PUB23 a drought signaling pathway by ubiquitinating cytosolic RPN12a. Acts as negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB23 and PUB24. Regulates EXO70B2 ubiquitination and degradation via the 26S proteasome to attenuate PAMP-induced signaling. (435 aa)
WRKY29Probable WRKY transcription factor 29; Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element. Activates WRKY 22, SIRK and its own promoters; Belongs to the WRKY group II-e family. (304 aa)
NPC4Non-specific phospholipase C4; Non-specific phospholipase C (PLC) which assumes major PLC activity during inorganic phosphate starvation. Substrate preference is phosphatidylcholine (PC), but can also hydrolyze phosphatidylethanolamine (PE) with lower efficiency. Has no activity toward phosphatidic acid (PA). Plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids during phosphate deprivation. May be required for lipid- derived signaling molecules that positively modulate abscisic acid (ABA) response and promote plant t [...] (538 aa)
PUB13U-box domain-containing protein 13; Functions as an E3 ubiquitin ligase. (660 aa)
SERK4Somatic embryogenesis receptor kinase 4; Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Positively regulates the BR-dependent plant growth pathway and negatively regulates the BR-independent cell- death pathway. (620 aa)
SOBIR1Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1; Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Acting as a counterplayer of BIR1, promotes the activation of plant defense and cell death. Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity. Functions as an inhibitor/regulator of abscission, probably by regulating membrane trafficking during abscission. (641 aa)
LYK2Protein LYK2; May recognize microbe-derived N-acetylglucosamine (NAG)- containing ligands. (654 aa)
PUB24E3 ubiquitin-protein ligase PUB24; E3 ubiquitin-protein ligase that acts as negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB22 and PUB23. (456 aa)
NPC5Non-specific phospholipase C5; Non-specific phospholipase C (PLC) which assumes minor PLC activity during inorganic phosphate starvation. Can hydrolyze both phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Required for normal accumulation of digalactosyldiacylglycerol (DGDG) during phosphate limitation and may contribute to the conversion of phospholipids to diacylglycerol, the substrate for galactolipid synthesis. (521 aa)
FER4Ferritin-4, chloroplastic; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity); Belongs to the ferritin family. (259 aa)
F13M7.4Putative BPI/LBP family protein At1g04970. (488 aa)
RLP30Receptor-like protein 30; Receptor for microbe-associated molecular patterns (MAMPs) that induces a BAK1-dependent basal immune response to necrotrophic fungi (e.g. S.sclerotiorum) in the presence of MAMPs (e.g. flg22 and SCLEROTINIA CULTURE FILTRATE ELICITOR1 (SCFE1) from the necrotrophic fungal pathogen S. sclerotiorum). Functionality seems to depend on the presence of the receptor kinase SOBIR1 as an adapter protein. Required for full non-host resistance to bacterial pathogens (e.g. P.syringae pv phaseolicola). Belongs to the RLP family. (786 aa)
RALF23Rapid alkalinization factor 23; Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity). Regulates negatively brassinolide (BL)-mediated signaling pathway (e.g. BL-induced hypocotyl elongation and branching limitation). (138 aa)
BIR2Inactive LRR receptor-like serine/threonine-protein kinase BIR2; Pseudokinases lacking protein kinase activity and unable to bind ATP-analogs. Negative regulator of pathogen- associated molecular patterns- (PAMP-) triggered immunity by limiting BAK1-receptor complex formation in the absence of ligands. (605 aa)
CERK1Chitin elicitor receptor kinase 1; Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e.g. tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection). Recognizes microbe-derived N-acetylglucosamine (NAG)- containing ligands. Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patt [...] (617 aa)
EFRLRR receptor-like serine/threonine-protein kinase EFR; Constitutes the pattern-recognition receptor (PPR) that determines the specific perception of elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Reduces transformation by Rhizobium radiobacter probably by inducing plant defense during the interaction. Binding to the effector AvrPto1 from P.syringae blocks the downstream plant immune response while interaction with hopD2 decreases the phosphorylation level of EFR upon elf18 treatment. Specific endoplasmic reticu [...] (1031 aa)
LYK5Protein LYK5; May recognize microbe-derived N-acetylglucosamine (NAG)- containing ligands; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (664 aa)
LYM2LysM domain-containing GPI-anchored protein 2; Chitin elicitor-binding protein involved in the perception of chitin oligosaccharide elicitor. (350 aa)
BIK1Serine/threonine-protein kinase BIK1; Plays a central role in immune responses. Required to activate the resistance responses to necrotrophic pathogens. Phosphorylates FLS2 and BAK1. Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2. Acts additively with PBL1 in PTI defenses. Acts as positive regulator of the PAMP flg22-induced increase of cytosolic calcium. Binds directly and phosphorylates the NADPH oxidase RBOHD at specific sites in a calcium-independent manner to enhance reactive oxygen species (ROS) [...] (395 aa)
RLP23Receptor like protein 23; Involved in the perception of necrosis and ethylene-inducing peptide 1-like proteins (NLPs), that act as extracellular signals mediating immune activation. Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity. (890 aa)
SIRKSenescence-induced receptor-like serine/threonine-protein kinase; Involved in innate immune response of plants. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (876 aa)
LYK4LysM domain receptor-like kinase 4; Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity. Recognizes microbe-derived N- acetylglucosamine (NAG)-containing ligands. Involved in the resistance to the pathogenic fungus Alternaria brassicicola and to the bacterial pathogen the bacterial pathogen Pseudomonas syringae pv tomato DC3000, probably by sensing microbe-associated molecular pattern (MAMP) and pathogen-associated molecular patterns (PAMP). May play a role in detecting peptidoglyca [...] (612 aa)
DBPRemorin; Exhibits a non sequence-specific DNA-binding activity. (190 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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