STRINGSTRING
T11J7.12 T11J7.12 PTI13 PTI13 RGI3 RGI3 EFR EFR F21D18.32 F21D18.32 F14B2.17 F14B2.17 F4K6Z5_ARATH F4K6Z5_ARATH AGO1 AGO1 PTI12 PTI12 PTI1-4 PTI1-4 ATHB-4 ATHB-4 NPR1 NPR1 MEKK1 MEKK1 RPM1 RPM1 NPR4 NPR4 PTI11 PTI11 NPR3 NPR3 BSL1 BSL1 ERF1B ERF1B ARPN ARPN T10F18.130 T10F18.130 PBS1 PBS1 SPL11 SPL11 sks13 sks13 sks11 sks11 CARK1 CARK1 LAC13 LAC13 NPR6 NPR6 T17J13.180 T17J13.180 EIN2 EIN2 EDS1 EDS1 NPR2 NPR2 NPR5 NPR5 Sks12 Sks12
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
T11J7.12Protein kinase superfamily protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (348 aa)
PTI13PTI1-like tyrosine-protein kinase 3. (408 aa)
RGI3LRR receptor-like serine/threonine-protein kinase; Acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT). Links RGF1 signal with its downstream components. (1091 aa)
EFRLRR receptor-like serine/threonine-protein kinase EFR; Constitutes the pattern-recognition receptor (PPR) that determines the specific perception of elongation factor Tu (EF-Tu), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Reduces transformation by Rhizobium radiobacter probably by inducing plant defense during the interaction. Binding to the effector AvrPto1 from P.syringae blocks the downstream plant immune response while interaction with hopD2 decreases the phosphorylation level of EFR upon elf18 treatment. Specific endoplasmic reticu [...] (1031 aa)
F21D18.32Protein kinase superfamily protein; Belongs to the protein kinase superfamily. (363 aa)
F14B2.17Protein kinase superfamily protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (440 aa)
F4K6Z5_ARATHPlant L-ascorbate oxidase; Belongs to the multicopper oxidase family. (588 aa)
AGO1Protein argonaute 1; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Requires DRB1 for directional loading of the small RNA duplex (guide stand and passenger strand) onto RISC for passenger strand degradation. Unlike animal RISC that associates in high molecular weight complex, Arabidopsis RISC i [...] (1048 aa)
PTI12PTI1-like tyrosine-protein kinase 2; Probable tyrosine-protein kinase involved in oxidative burst- mediated signaling leading to specific genes expression. (366 aa)
PTI1-4Probable receptor-like protein kinase At2g47060; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (365 aa)
ATHB-4Homeobox-leucine zipper protein ATHB-4; Probable transcription factor; Belongs to the HD-ZIP homeobox family. Class II subfamily. (318 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
MEKK1Mitogen-activated protein kinase kinase kinase 1; The MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in the cold and salinity stress-mediated MAP kinase signaling cascade (MEKK1, MKK1/MKK2 and MPK4/MPK6). Activates by phosphorylation the downstream [...] (608 aa)
RPM1Disease resistance protein RPM1; Disease resistance (R) protein that specifically recognizes the AvrRpm1 type III effector avirulence protein from Pseudomonas syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Acts via its interaction with RIN4, and probably triggers the plant resistance when RIN4 is phosphorylated by AvrRpm1. It is then degraded at the onset of th [...] (926 aa)
NPR4Regulatory protein NPR4; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. (574 aa)
PTI11PTI1-like tyrosine-protein kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (361 aa)
NPR3Regulatory protein NPR3; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens. (586 aa)
BSL1Serine/threonine-protein phosphatase BSL1; Phosphatase involved in elongation process, probably by acting as a regulator of brassinolide signaling. (881 aa)
ERF1BEthylene-responsive transcription factor 1B; Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression during the plant development, and/or mediated by stress factors and by components of stress signal transduction pathways. Seems to be a key integrator of ethylene and jasmonate signals in the regulation of ethylene/jasmonate-dependent defenses. Can mediate resistance to necrotizing fungi (Botrytis cinerea and Plectosphaerella cucumerina) and to soil borne fungi (Fusarium oxysporum conglutinans and Fus [...] (218 aa)
ARPNBasic blue protein; Forms a concentration gradient along the pollen tube growth path, with a lower level in the stigma papilla cell wall and a higher level in the transmitting tract extracellular matix of the style. (129 aa)
T10F18.130Ascorbate oxidase-like protein; Belongs to the multicopper oxidase family. (573 aa)
PBS1Serine/threonine-protein kinase PBS1; Protein kinase required for plant defense mechanism mediated by the disease resistance (R) protein RPS5. In case of infection by Pseudomonas syringae, AvrPphB triggers RPS5-mediated defense mechanism via the cleavage of PBS1. Both kinase activity and cleavage by avrPphB are independently required to trigger the RPS5-mediated resistance. Contributes to PAMP-triggered immunity (PTI) signaling and defense responses downstream of FLS2. (456 aa)
SPL11Squamosa promoter-binding-like protein 11; Trans-acting factor that binds specifically to the consensus nucleotide sequence 5'-TNCGTACAA-3'. (393 aa)
sks13BNH protein pectinesterase-like protein pollen-secific protein-like. (551 aa)
sks11L-ascorbate oxidase pectinesterase-like protein pollen-specific protein-like. (554 aa)
CARK1Receptor-like cytoplasmic kinase 1; Receptor-like cytoplasmic kinase (RLCK) that triggers abscisic acid (ABA) signaling by phosphorylating and activating ABA receptors (e.g. PYL8/RCAR3 and PYR1/RCAR11), which in turn repress ABI1, a negative regulator of ABA responses. Promotes drought tolerance ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (364 aa)
LAC13Laccase-13; Lignin degradation and detoxification of lignin-derived products. (569 aa)
NPR6Regulatory protein NPR6; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB [...] (467 aa)
T17J13.180Serine/threonine protein kinase-like protein; Belongs to the protein kinase superfamily. (361 aa)
EIN2Ethylene-insensitive protein 2; Central factor in signaling pathways regulated by ethylene (ET), and involved in various processes including development, plant defense, senescence, nucleotide sugar flux, and tropisms. Necessary for ethylene-mediated gene regulation, and for the induction of some genes by ozone. Acts downstream of ET receptors, and upstream of ethylene regulated transcription factors. Required for cytokinin-mediated processes. Seems to be implicated in cross-talk between ET, jasmonate and other pathways. Probably not involved in iron uptake. Has a short half-life and un [...] (1294 aa)
EDS1Protein EDS1; Positive regulator of basal resistance and of effector- triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation. Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling. Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid. Nuclear localization is essential for bas [...] (623 aa)
NPR2Regulatory protein NPR2; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (600 aa)
NPR5Regulatory protein NPR5; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB [...] (491 aa)
Sks12At1g55570/T5A14_1. (555 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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