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CSY2 CSY2 CSY1 CSY1 MLS MLS F1I16_220 F1I16_220 F1I16_60 F1I16_60 CSY5 CSY5 PKP4 PKP4 CYFBP CYFBP PGK3 PGK3 ACO3 ACO3 CSY3 CSY3 F1O11.21 F1O11.21 ICDH ICDH T11I18.16 T11I18.16 CICDH CICDH HKL3 HKL3 GAPC2 GAPC2 A0A1P8ARU2 A0A1P8ARU2 ISA1 ISA1 M3E9.180 M3E9.180 CSY4 CSY4 GAPC1 GAPC1 ICL ICL PGIC PGIC ATHB-5 ATHB-5 ACT4 ACT4 HXK2 HXK2 HXK1 HXK1 ACO1 ACO1 ATHXK4 ATHXK4 PGI1 PGI1 T15N1.80 T15N1.80 PKP3 PKP3 ACO2-2 ACO2-2 Q94KE3_ARATH Q94KE3_ARATH MBK5.16 MBK5.16 PKP2 PKP2 MCD7.8 MCD7.8 MAH20.13 MAH20.13 HXK3 HXK3 PKP1 PKP1 HKL1 HKL1 Q9LU95_ARATH Q9LU95_ARATH
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CSY2Citrate synthase 2, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (514 aa)
CSY1Citrate synthase 1, peroxisomal; Belongs to the citrate synthase family. (480 aa)
MLSMalate synthase; Does not seem to be essential for lipid utilization and gluconeogenesis in seedlings; Belongs to the malate synthase family. (562 aa)
F1I16_220Pyruvate kinase; Belongs to the pyruvate kinase family. (492 aa)
F1I16_60Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
CSY5Citrate synthase 5, mitochondrial; Belongs to the citrate synthase family. (464 aa)
PKP4Plastidial pyruvate kinase 4, chloroplastic. (710 aa)
CYFBPFructose-1,6-bisphosphatase, cytosolic; Catalyzes the first irreversible reaction from fructose-1,6- bisphosphate to fructose-6-phosphate and inorganic phosphate and plays an important regulatory role in sucrose biosynthesis and metabolism (Probable). Its activity is essential to regulate starch levels. Functions in fructose-mediated signaling independently of its catalytic activity in sugar metabolism. May act downstream of ABA2/GIN1, which is involved in abscisic acid (ABA) synthesis to regulate autotrophic transition and modulate early seedling establishment after seed germination. [...] (341 aa)
PGK3Phosphoglycerate kinase 3, cytosolic; Belongs to the phosphoglycerate kinase family. (401 aa)
ACO3Aconitate hydratase 3, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. Modulates cytosolic citrate metabolism during lipid mobilization. Required during seedling growth. Belongs to the aconitase/IPM isomerase family. (990 aa)
CSY3Citrate synthase 3, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria. (509 aa)
F1O11.21Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
ICDHPeroxisomal isocitrate dehydrogenase [NADP]; May be involved in response to oxidative stresses. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (416 aa)
T11I18.16Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
CICDHCytosolic isocitrate dehydrogenase [NADP]; May supply 2-oxoglutarate for amino acid biosynthesis and ammonia assimilation via the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway. May be involved in the production of NADPH to promote redox signaling or homeostasis in response to oxidative stress. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (410 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
GAPC2Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro. (338 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
ISA1Isoamylase 1, chloroplastic; Involved in the trimming of pre-amylopectin chains. Accelerates the crystallization of nascent amylopectin molecules during starch synthesis. ISA1 and ISA2 work exclusively together as a multimeric holoenzyme. ISA1-ISA2 removes preferentially branches that are very close to other branches. (783 aa)
M3E9.180Probable pyruvate kinase, cytosolic isozyme; Key regulatory enzyme of the glycolytic pathway that catalyzes the final step of glycolysis, converting ADP and phosphoenolpyruvate (PEP) to ATP and pyruvate by essentially irreversible transphosphorylation. (497 aa)
CSY4Citrate synthase 4, mitochondrial; Belongs to the citrate synthase family. (474 aa)
GAPC1Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to [...] (338 aa)
ICLIsocitrate lyase; Involved in storage lipid mobilization during the growth of higher plant seedling; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family. (576 aa)
PGICGlucose-6-phosphate isomerase, cytosolic; Belongs to the GPI family. (560 aa)
ATHB-5Homeobox-leucine zipper protein ATHB-5; Probable transcription factor that acts as a positive regulator of ABA-responsiveness, mediating the inhibitory effect of ABA on growth during seedling establishment. Binds to the DNA sequence 5'- CAATNATTG-3'. (312 aa)
ACT4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the reproductive actins. (377 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
ACO1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. May have a role in respiration. Belongs to the aconitase/IPM isomerase family. (898 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
PGI1Glucose-6-phosphate isomerase 1, chloroplastic; Promotes the synthesis of starch in leaves. (613 aa)
T15N1.80Isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial; May be involved in response to oxidative stresses. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (485 aa)
PKP3Plastidial pyruvate kinase 3, chloroplastic; Required for plastidial pyruvate kinase activity. (571 aa)
ACO2-2Aconitate hydratase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. Contributes to oxidative stress tolerance. Involved in acetate assimilation. (995 aa)
Q94KE3_ARATHPyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
MBK5.16Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
PKP2Plastidial pyruvate kinase 2; Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination. (579 aa)
MCD7.8Pyruvate kinase; Belongs to the pyruvate kinase family. (498 aa)
MAH20.13Pyruvate kinase; Belongs to the pyruvate kinase family. (510 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
PKP1Plastidial pyruvate kinase 1, chloroplastic; Required for plastidial pyruvate kinase activity. Involved in seed oil accumulation, embryo development and seed storage compounds mobilization upon germination. (596 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
Q9LU95_ARATHPyruvate kinase; Belongs to the pyruvate kinase family. (497 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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