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WRKY8 WRKY8 NPR1 NPR1 T25N20.10 T25N20.10 GAPCP2 GAPCP2 WRKY28 WRKY28 WRKY54 WRKY54 WRKY64 WRKY64 WRKY18 WRKY18 SARD1 SARD1 PDF1.2A PDF1.2A RBOHD RBOHD EDR1 EDR1 GAPC2 GAPC2 CDC73 CDC73 CPR5 CPR5 WRKY70 WRKY70 TAAC TAAC PAD4 PAD4 ICS1 ICS1 WRKY40 WRKY40 GAPCP1 GAPCP1 WRKY1 WRKY1 WRKY46 WRKY46 TIR TIR EDS1 EDS1 HMGB6 HMGB6 RPP4 RPP4 K19M22.8 K19M22.8 COI1 COI1 RBOHF RBOHF VSP1 VSP1 ACD11 ACD11 VSP2 VSP2 RRS1 RRS1 GAPC1 GAPC1 PR5 PR5
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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WRKY8WRKY transcription factor 8; Transcription factor. Interacts specifically with the W box (5'-TTGAC[CT]-3'), a frequently occurring stress-responsive cis-acting element. Functions as positive regulator of salt stress response. Binds the W box of LTI78/RD29A stress-response gene and directly regulates its transcription under salt stress. Functions antagonistically with VQ9 to regulate sodium and potassium homeostasis under salt stress by regulating the expression of downstream SOS (SALT OVERLY SENSITIVE) stress-responsive genes. The DNA-binding activity of WRKY8 is decreased by VQ9. Func [...] (326 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
T25N20.10Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein. (205 aa)
GAPCP2Glyceraldehyde-3-phosphate dehydrogenase GAPCP2, chloroplastic; Involved in plastidial glycolytic pathway and plays a specific role in glycolytic energy production in non-green plastids and chloroplasts. Essential for breakdown of starch to form sucrose for export to non-photosynthetic tissues, and to generate primary metabolites for anabolic pathways such as fatty acid and amino acid synthesis. Plays an important role in plant development by providing substrates for the phosphorylated pathway of serine biosynthesis in roots. Plays a crucial role in pollen development. Functionally red [...] (420 aa)
WRKY28WRKY transcription factor 28; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-c family. (318 aa)
WRKY54Probable WRKY transcription factor 54; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity). Together with WRKY70, negative regulator of developmental senescence, probably via the regulation of several senescence-associated markers genes. Positive regulator of EDS1-dependent defense against E.amylovora. In collaboration with WRKY70, prevents stomatal closure and, consequently, osmotic stress tolerance. Together with WRKY46 and WRKY70, promotes brassinosteroid (BR)- regulated plant [...] (346 aa)
WRKY64Probable WRKY transcription factor 64; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group III family. (249 aa)
WRKY18WRKY transcription factor 18; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Positively modulates defense-related gene expression and disease resistance; Belongs to the WRKY group II-a family. (310 aa)
SARD1Protein SAR DEFICIENT 1; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P. syringae pv. maculicola and Hyaloperonospora arabidopsidis. Belongs to the plant ACBP60 prote [...] (451 aa)
PDF1.2ADefensin-like protein 16; Confers broad-spectrum resistance to pathogens. Has antifungal activity in vitro; Belongs to the DEFL family. (80 aa)
RBOHDRespiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family. (921 aa)
EDR1Serine/threonine-protein kinase EDR1; MAPKKK serine/threonine-protein kinase involved in the regulation of a MAP kinase cascade (probably including MPK3 and MPK6) that negatively regulates salicylic acid- (SA-) dependent defense responses, abscisic acid (ABA) signaling, and ethylene-induced senescence. Modulates also stress response (e.g. drought) signaling and cell death, in an ORE9-dependent manner. Functions at a point of cross talk between ethylene, ABA and SA signaling that impinges on senescence and cell death. On the other hand, it confers sensitivity to various pathogens such a [...] (933 aa)
GAPC2Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity). Binds DNA in vitro. (338 aa)
CDC73Protein CDC73 homolog; Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3). Involved in regulation of flowering time. Required for the expression of the flowering repressors FLC and MADS- box genes of the MAF family. Required for histone H3 trimethylation on 'Lys-4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27' (H3K27me3) at the same locus. (415 aa)
CPR5Protein CPR-5; May play a role in transcriptional processes. Regulates negatively the senescence and chlorotic lesions induced by biotic (e.g. pathogens) and abiotic (e.g. sugars, darkness) agents, probably by controlling programmed cell death (pcd). Negative regulator of plant programmed cell death (PCD) and effector-triggered immunity (ETI). Promotes cell division and endoreduplication (e.g. in trichomes). (564 aa)
WRKY70Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa)
TAACThylakoid ADP,ATP carrier protein, chloroplastic; Specifically transports adenine nucleotides. Involved in the uptake of ATP into thylakoids in exchange for lumenal ADP. (415 aa)
PAD4Lipase-like PAD4; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe- associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS-LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response to the fungal toxin fumo [...] (541 aa)
ICS1Isochorismate synthase 1, chloroplastic; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity. (569 aa)
WRKY40Probable WRKY transcription factor 40; Transcription factor (By similarity). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor- responsive cis-acting element (By similarity). (302 aa)
GAPCP1Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic; Involved in plastidial glycolytic pathway and plays a specific role in glycolytic energy production in non-green plastids and chloroplasts. Essential for breakdown of starch to form sucrose for export to non-photosynthetic tissues, and to generate primary metabolites for anabolic pathways such as fatty acid and amino acid synthesis. Plays an important role in plant development by providing substrates for the phosphorylated pathway of serine biosynthesis in roots. Plays a crucial role in pollen development. Functionally red [...] (422 aa)
WRKY1WRKY transcription factor 1; Transcription factor. Binds to a 5'-CGTTGACCGAG-3' consensus core sequence which contains a W box, a frequently occurring elicitor- responsive cis-acting element; Belongs to the WRKY group I family. (487 aa)
WRKY46Probable WRKY transcription factor 46; Transcription factor involved in the regulation of osmotic stress responses and stomatal movement. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Positive regulator of EDS1-dependent defense against E.amylovora. Together with WRKY70 and WRKY53, promotes resistance to P.syringae, probably by enhancing salicylic acid (SA)- dependent genes. Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1.2. Together with WRKY54 and WRKY70, prom [...] (295 aa)
TIRToll/interleukin-1 receptor-like protein; Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity). (176 aa)
EDS1Protein EDS1; Positive regulator of basal resistance and of effector- triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation. Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling. Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid. Nuclear localization is essential for bas [...] (623 aa)
HMGB6High mobility group B protein 6. (456 aa)
RPP4Disease resistance protein RPP4; TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Hyaloperonospora arabidopsis isolates Emoy2 and Emwa1 (downy mildew disease). Plays a role in the regulation of temperature response during plant growth and survival. (1147 aa)
K19M22.8LRR protein. (1089 aa)
COI1Coronatine-insensitive protein 1; Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles [...] (592 aa)
RBOHFRespiratory burst oxidase homolog protein F; Calcium-dependent NADPH oxidase that generates superoxide. Generates reactive oxygen species (ROS) during incompatible interactions with pathogens and is important in the regulation of the hypersensitive response (HR). Involved in abscisic acid-induced stomatal closing and in UV-B and abscisic acid ROS-dependent signaling. Belongs to the RBOH (TC 5.B.1.3) family. (944 aa)
VSP1Vegetative storage protein 1; May function as somatic storage protein during early seedling development; Belongs to the APS1/VSP family. (270 aa)
ACD11Accelerated cell death 11; Exhibits selective intermembrane transfer of ceramide-1- phosphate (C1P) and phytoceramide-1-phosphate. Does not transport ceramide (Cer) or GalCer, suggesting a requirement for phosphate in the headgroup for functionality. Transports in vitro sphingosine, but not glycosphigolipids. Has also some in vitro activity with sphingomyelin, a lipid not detected in plant tissues. The transport function may be not directly involved in regulating cell death. Rather, perturbations in the function of ACD11 or related components could be monitored by R-proteins, which the [...] (206 aa)
VSP2Vegetative storage protein 2; May function as somatic storage protein during early seedling development; Belongs to the APS1/VSP family. (265 aa)
RRS1Disease resistance protein RRS1; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Acts also as a disease resistance protein involved in resistance to fungal and bacterial pathogens, including R.solanacearum, P.syringae pv. tomato and C.higginsianum. Heterodimerization with RPS4 is required to form a functional complex to recognize AvrRps4 and PopP2. Contributes to temperature-conditioned RPS4 auto- immunity. (1288 aa)
GAPC1Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic; Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3- phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism. Required for full fertility. Involved in response to oxidative stress by mediating plant responses to abscisic acid (ABA) and water deficits through the activation of PLDDELTA and production of phosphatidic acid (PA), a multifunctional stress signaling lipid in plants. Associates with FBA6 to [...] (338 aa)
PR5Pathogenesis-related protein 5; Partially responsible for acquired pathogen resistance. (239 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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