STRINGSTRING
MPK1 MPK1 TLP1 TLP1 CBP60A CBP60A CBP60G CBP60G K19M22.8 K19M22.8 WRKY23 WRKY23 MES9 MES9 ERF2 ERF2 ERF4 ERF4 PER25 PER25 MLO12 MLO12 T16L1.210 T16L1.210 T16L1.220 T16L1.220 PR5 PR5 PR1-2 PR1-2 HEL HEL NPR1 NPR1 PR-1-LIKE PR-1-LIKE PR1 PR1 RPM1 RPM1 TIP1-2 TIP1-2 AAP1 AAP1 SAG101 SAG101 NPR4 NPR4 NPF7.2 NPF7.2 RBK1 RBK1 MIOX4 MIOX4 NPR3 NPR3 ATL31 ATL31 GPT2 GPT2 MLO6 MLO6 NAC030 NAC030 SARD1 SARD1 BZIP8 BZIP8 PDF1.2A PDF1.2A NIMIN-1 NIMIN-1 NAC083 NAC083 PER37 PER37 Q9LJM5_ARATH Q9LJM5_ARATH F2J10.6 F2J10.6 PEP1 PEP1 WRKY70 WRKY70 GH3.12 GH3.12 ICS2 ICS2 PAD4 PAD4 ICS1 ICS1 JAR1 JAR1 TIR TIR HOP3 HOP3 PMEI11 PMEI11 EDS1 EDS1 MLO2 MLO2 PRB1 PRB1 EGC2 EGC2 CUL3A CUL3A
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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MPK1Mitogen-activated protein kinase 1. (370 aa)
TLP1Thaumatin-like protein 1; Involved in local responses of roots to colonization by non- pathogenic plant growth-promoting rhizobacteria (PGPR) fluorescent Pseudomonas spp., but seems to not being required for the establishment of subsequent induced systemic resistance (ISR). (260 aa)
CBP60ACalmodulin-binding protein 60 A; Transcription activator that binds DNA in a sequence-specific manner, likely 5'-GAAATTTTGG-3', to promote the expression of target genes. (494 aa)
CBP60GCalmodulin-binding protein 60 G; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1, PR2 and EDS5) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326, P. syringae pv. tomato DC3000, and microbe- associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e.g. UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis. Involved in b [...] (563 aa)
K19M22.8LRR protein. (1089 aa)
WRKY23WRKY transcription factor 23; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-c family. (337 aa)
MES9Methylesterase 9; Methylesterase shown to have carboxylesterase activity, methyl indole-3-acetic acid (MeIAA) esterase activity, methyl salicylate (MeSA) esterase activity and methyl jasmonate (MeJA) esterase activity in vitro. Required to convert methyl salicylate (MeSA) to salicylic acid (SA) as part of the signal transduction pathways that activate systemic acquired resistance in systemic tissue. MeSA is believed to be an inactive form that needs to be demethylated to exert a biological effect; Belongs to the AB hydrolase superfamily. Methylesterase family. (256 aa)
ERF2Ethylene-responsive transcription factor 2; Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. Involved in disease resistance pathways. Belongs to the AP2/ERF transcription factor family. ERF subfamily. (243 aa)
ERF4Ethylene-responsive transcription factor 4; Acts as a transcriptional repressor. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways, and could also regulate other AtERFs. (222 aa)
PER25Peroxidase 25; Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue; Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily. (328 aa)
MLO12MLO-like protein 12; May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity). (576 aa)
T16L1.210Putative pathogenesis-related protein 1, 19.3K; Belongs to the CRISP family. (163 aa)
T16L1.220Pathogenesis-related protein-like; Belongs to the CRISP family. (172 aa)
PR5Pathogenesis-related protein 5; Partially responsible for acquired pathogen resistance. (239 aa)
PR1-2Pathogenesis-related protein 1; Partially responsible for acquired pathogen resistance. (161 aa)
HELHevein-like preproprotein; Fungal growth inhibitors. Neither CB-HEL nor CD-HEL have chitinase activity, but both have antimicrobial activities. CD-HEL has RNase, but no DNase activity. (212 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
PR-1-LIKEPathogenesis-related protein-1-like protein; Belongs to the CRISP family. (176 aa)
PR1Putative pathogenesis-related protein 1, 18.9K; Belongs to the CRISP family. (166 aa)
RPM1Disease resistance protein RPM1; Disease resistance (R) protein that specifically recognizes the AvrRpm1 type III effector avirulence protein from Pseudomonas syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Acts via its interaction with RIN4, and probably triggers the plant resistance when RIN4 is phosphorylated by AvrRpm1. It is then degraded at the onset of th [...] (926 aa)
TIP1-2Aquaporin TIP1-2; Water channel required to facilitate the transport of water across cell membrane. May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition. Transports urea in yeast cells in a pH-independent manner. Transports H(2)O(2) in yeast cells. (253 aa)
AAP1Amino acid permease 1; Amino acid-proton symporter. Stereospecific transporter with a broad specificity for histidine, glutamate and neutral amino acids. Reduced affinities for asparagine and valine. Involved in amino acid uptake from the apoplastic cavity into the embryo cells for storage protein accumulation and in root amino acid uptake. (485 aa)
SAG101Senescence-associated carboxylesterase 101; Acyl hydrolase that triggers the leaf senescence onset. Can use triolein as substrate to produce oleic acids. (537 aa)
NPR4Regulatory protein NPR4; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. (574 aa)
NPF7.2Protein NRT1/ PTR FAMILY 7.2; Low-affinity nitrate transporter. Involved in nitrate removal from xylem sap. Not involved in oligopeptides transport. (589 aa)
RBK1Receptor-like cytosolic serine/threonine-protein kinase RBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (467 aa)
MIOX4Inositol oxygenase 4; Involved in the biosynthesis of UDP-glucuronic acid (UDP- GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis. (317 aa)
NPR3Regulatory protein NPR3; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens. (586 aa)
ATL31E3 ubiquitin-protein ligase ATL31; E3 ubiquitin-protein ligase that is required for the plant C/N response during seedling growth transition. May be involved in the early steps of the plant defense signaling pathway. (368 aa)
GPT2Glucose-6-phosphate/phosphate translocator 2, chloroplastic; Glucose 6-phosphate (Glc6P) transporter. Transports also inorganic phosphate, 3-phosphoglycerate, triose phosphates and, to a leser extent, phosphoenolpyruvate. Responsible for the transport of Glc6P into plastids of heterotrophic tissues where it can be used as a carbon source for starch biosynthesis, as substrate for fatty acid biosynthesis or as substrate for NADPH generation via the oxidative pentose phosphate pathway (OPPP). Required for dynamic acclimation of photosynthesis; Belongs to the TPT transporter family. GPT (T [...] (388 aa)
MLO6MLO-like protein 6; May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity); Belongs to the MLO family. (583 aa)
NAC030NAC domain-containing protein 30; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating protoxylem vessel differentiation by promoting immature xylem vessel-specific genes expression. Can activate the expression of several genes including XCP1, MYB46, NAC010/SND3, MYB10 [...] (324 aa)
SARD1Protein SAR DEFICIENT 1; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P. syringae pv. maculicola and Hyaloperonospora arabidopsidis. Belongs to the plant ACBP60 prote [...] (451 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
PDF1.2ADefensin-like protein 16; Confers broad-spectrum resistance to pathogens. Has antifungal activity in vitro; Belongs to the DEFL family. (80 aa)
NIMIN-1Protein NIM1-INTERACTING 1; Belongs to the NPR1-interactor family. (142 aa)
NAC083NAC domain-containing protein 83; Transcriptional repressor that negatively regulates the expression of genes involved in xylem vessel formation. Represses the transcriptional activation activity of NAC030/VND7, which regulates protoxylem vessel differentiation by promoting immature xylem vessel- specific genes expression. Transcriptional activator that regulates the COLD-REGULATED (COR15A and COR15B) and RESPONSIVE TO DEHYDRATION (LTI78/RD29A and LTI65/RD29B) genes by binding directly to their promoters. Mediates signaling crosstalk between salt stress response and leaf aging process. [...] (252 aa)
PER37Peroxidase 37; Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue; Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily. (346 aa)
Q9LJM5_ARATHPathogenesis-related protein-like; Belongs to the CRISP family. (161 aa)
F2J10.6F2J10.6 protein; Belongs to the CRISP family. (161 aa)
PEP1Elicitor peptide 1; Elicitor of plant defense. Induces the production of plant defensin (PDF1.2) and of H(2)O(2). Promotes resistance to the root fungal pathogen P.irregulare. (92 aa)
WRKY70Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa)
GH3.124-substituted benzoates-glutamate ligase GH3.12; Catalyzes the conjugation of specific amino acids (e.g. Glu and possibly His, Lys, and Met) to their preferred acyl substrates (e.g. 4-substituted benzoates), in a magnesium ion- and ATP-dependent manner. Can use 4-substituted benzoates such as 4-aminobenzoate (pABA), 4-fluorobenzoate and 4-hydroxybenzoate (4-HBA), and, to a lesser extent, benzoate, vanillate and trans-cinnamate, but not 2-substituted benzoates and salicylic acid (SA), as conjugating acyl substrates. Involved in both basal and induced resistance in a SA-dependent manner. [...] (575 aa)
ICS2Isochorismate synthase 2, chloroplastic; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity. (562 aa)
PAD4Lipase-like PAD4; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe- associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS-LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response to the fungal toxin fumo [...] (541 aa)
ICS1Isochorismate synthase 1, chloroplastic; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity. (569 aa)
JAR1Jasmonoyl--L-amino acid synthetase JAR1; Catalyzes the synthesis of jasmonates-amino acid conjugates by adenylation; can use Ile and, in vitro at least, Val, Leu and Phe as conjugating amino acids on jasmonic acid (JA) and 9,10-dihydro-JA substrates, and to a lower extent, on 3-oxo-2-(2Z-pentenyl)- cyclopentane-1-butyric acid (OPC-4) and 12-hydroxy-JA (12-OH-JA). Can synthesize adenosine 5-tetraphosphate in vitro. Required for the JA- mediated signaling pathway that regulates many developmental and defense mechanisms, including growth root inhibition, vegetative storage proteins (VSPs) [...] (575 aa)
TIRToll/interleukin-1 receptor-like protein; Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity). (176 aa)
HOP3Hsp70-Hsp90 organizing protein 3; Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity). Involved in acclimation to heat. (558 aa)
PMEI11Pectinesterase inhibitor 11; Pectin methylesterase (PME) inhibitor involved in the maintenance of cell wall integrity in response to necrotrophic pathogens. Modulates PME activity and pectin methylesterification during infection by Botrytis cinerea and contributes to resistance against the pathogen; Belongs to the PMEI family. (202 aa)
EDS1Protein EDS1; Positive regulator of basal resistance and of effector- triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation. Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling. Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid. Nuclear localization is essential for bas [...] (623 aa)
MLO2MLO-like protein 2; May be involved in modulation of pathogen defense and leaf cell death. Activity seems to be regulated by Ca(2+)-dependent calmodulin binding and seems not to require heterotrimeric G proteins (By similarity); Belongs to the MLO family. (573 aa)
PRB1Pathogenesis-related protein 1; Probably involved in the defense reaction of plants against pathogens. (161 aa)
EGC2EG45-like domain containing protein 2; Plays a systemic role in water and solute homeostasis. (130 aa)
CUL3ACullin-3A; Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component. Involved in embryo pattern formation and endosperm development. Required for the normal division and organization of the root stem cells and columella root cap cells. Regulates primary root growth by an unknown pathway, but in an ethylene-dependent manner. F [...] (732 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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