STRINGSTRING
HXK1 HXK1 ATHXK4 ATHXK4 CPL1 CPL1 SK2 SK2 ACS12 ACS12 PGI1 PGI1 MSJ1.11 MSJ1.11 XRN2 XRN2 HXK3 HXK3 TSN1 TSN1 A0A1P8ARU2 A0A1P8ARU2 PGIC PGIC EMB2360 EMB2360 DRT101 DRT101 HXK2 HXK2 RPL40B RPL40B ALD1 ALD1 HKL3 HKL3 TRE1 TRE1 SK1 SK1 PCR8 PCR8 ACS10 ACS10 HKL1 HKL1 ASK4-2 ASK4-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HXK1Hexokinase-1; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells. Promotes roots and leaves growth. Belongs to the hexokinase family. (496 aa)
ATHXK4Hexokinase-4; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (502 aa)
CPL1RNA polymerase II C-terminal domain phosphatase-like 1; Processively dephosphorylates 'Ser-5' but not 'Ser-2' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II. Together with CPL2, required for male gametes fertility. Multifunctional regulator that modulates plant growth, stress, and phytohormones responses. Negative regulator of stress gene transcription involved in abscisic acid (ABA) mediated and jasmonic acid (JA) mediated signaling pathways, NaCl, osmotic stress, wounding, and col [...] (967 aa)
SK2Shikimate kinase 2, chloroplastic; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Belongs to the shikimate kinase family. (300 aa)
ACS12Probable aminotransferase ACS12; Probable aminotransferase. Does not have 1-aminocyclopropane- 1-carboxylate synthase (ACS) activity, suggesting that it is not involved in ethylene biosynthesis. (495 aa)
PGI1Glucose-6-phosphate isomerase 1, chloroplastic; Promotes the synthesis of starch in leaves. (613 aa)
MSJ1.11Nuclear protein-like. (1269 aa)
XRN25'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Acts as an endogenous post-transcriptional gene silencing (PTGS) suppressor. Degrades miRNA-derived loops, excised during miRNA maturation in the nucleus. Involved in pre-rRNA processing. Involved in the primary exonucleolytic shortening of the 5' external transcribed spacer (5'ETS), required for endonucleolytic processing at site P by the U3 snoRNP complex. Involved with XRN3 in the 5'-end processing of 5.8S and 25S rRNAs. Contributes with XRN3 to polyadenylation-dependent nuclear RNA surveillance. Involved in the deg [...] (1012 aa)
HXK3Hexokinase-like 1 protein; Fructose and glucose phosphorylating enzyme. Belongs to the hexokinase family. (493 aa)
TSN1Ribonuclease TUDOR 1; Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress. Essential for the integrity and function of cytoplasmic messenger ribonucleoprotein (mRNP) complexes called stress granules (SGs) and processing bodies (PBs), sites of post-transcriptional gene regulation during stress (e.g. salt and heat). Involved in gibberellic acid (GA) biosynthesis. Essential for stress tolerance, probably by regulating mRNAs entering the secretory pathway. Component of stress granules (SGs) that reg [...] (991 aa)
A0A1P8ARU2Phosphotransferase. (186 aa)
PGICGlucose-6-phosphate isomerase, cytosolic; Belongs to the GPI family. (560 aa)
EMB2360Glutathione reductase, chloroplastic; Maintains high levels of reduced glutathione in the chloroplast. (565 aa)
DRT101Phosphoacetylglucosamine mutase; Interconverts GlcNAc-6-P and GlcNAc-1-P; Belongs to the phosphohexose mutase family. (556 aa)
HXK2Hexokinase-2; Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol. Acts as sugar sensor which may regulate sugar-dependent gene repression or activation. Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism. May regulate the execution of program cell death in plant cells ; Belongs to the hexokinase family. (502 aa)
RPL40BUbiquitin-60S ribosomal protein L40-2; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is inv [...] (128 aa)
ALD1Aminotransferase ALD1, chloroplastic; Aminotransferase involved in local and systemic acquired resistance (SAR) to the bacterial pathogen P.syringae. Required for salicylic acid (SA) and camalexin accumulation upon pathogen infection. Possesses aminotransferase activity in vitro and may generate amino- acid-derived defense signals in vivo. May be involved in ethylene- induced senescence signaling. Involved in the biosynthesis of pipecolate (Pip), a metabolite that orchestrates defense amplification, positive regulation of SA biosynthesis, and priming to guarantee effective local resist [...] (456 aa)
HKL3Probable hexokinase-like 2 protein; Fructose and glucose phosphorylating enzyme. (493 aa)
TRE1Trehalase; Involved in the regulation of trehalose content by hydrolyzing trehalose to glucose. (626 aa)
SK1Shikimate kinase 1, chloroplastic; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (303 aa)
PCR8Protein PLANT CADMIUM RESISTANCE 8; May be involved in heavy metals transport; Belongs to the cornifelin family. (190 aa)
ACS10Probable aminotransferase ACS10; Probable aminotransferase. Does not have 1-aminocyclopropane- 1-carboxylate synthase (ACS) activity, suggesting that it is not involved in ethylene biosynthesis. (557 aa)
HKL1Hexokinase-3; Fructose and glucose phosphorylating enzyme (By similarity). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity). (498 aa)
ASK4-2SKP1-like protein 4; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.