STRINGSTRING
T25N20.10 T25N20.10 SAHH1 SAHH1 BIK1 BIK1 IRX12 IRX12 LAC2 LAC2 PTP1 PTP1 NPR1 NPR1 LAC16 LAC16 ARAC3 ARAC3 LAC3 LAC3 NPR4 NPR4 LAC10 LAC10 TT10 TT10 NPR3 NPR3 LAC11 LAC11 BZIP8 BZIP8 RBOHD RBOHD LAC17 LAC17 LAC12 LAC12 LAC14 LAC14 LAC9 LAC9 LAC8 LAC8 LAC1 LAC1 LAC13 LAC13 NPR6 NPR6 SRK2C SRK2C LAC5 LAC5 LAC7 LAC7 NPR2 NPR2 LAC6 LAC6 NPR5 NPR5
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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T25N20.10Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein. (205 aa)
SAHH1Adenosylhomocysteinase 1; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Required for DNA methylation-dependent gene silencing. (485 aa)
BIK1Serine/threonine-protein kinase BIK1; Plays a central role in immune responses. Required to activate the resistance responses to necrotrophic pathogens. Phosphorylates FLS2 and BAK1. Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling and defense responses downstream of FLS2. Acts additively with PBL1 in PTI defenses. Acts as positive regulator of the PAMP flg22-induced increase of cytosolic calcium. Binds directly and phosphorylates the NADPH oxidase RBOHD at specific sites in a calcium-independent manner to enhance reactive oxygen species (ROS) [...] (395 aa)
IRX12Laccase-4; Lignin degradation and detoxification of lignin-derived products (By similarity). Required for secondary xylem cell wall lignification; Belongs to the multicopper oxidase family. (558 aa)
LAC2Laccase-2; Lignin degradation and detoxification of lignin-derived products (By similarity). Required for root elongation in dehydration conditions; Belongs to the multicopper oxidase family. (573 aa)
PTP1Protein-tyrosine-phosphatase PTP1; Protein-tyrosine-phosphatase that dephosphorylates and probably inhibits MPK6 in non-oxidative stress conditions. In association with MKP1, represses salicylic acid (SA) and camalexin biosynthesis, thus modulating defense response. May also repress MPK3. Dephosphorylates and inactivates MPK4 in vitro. (340 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
LAC16Laccase-16; Lignin degradation and detoxification of lignin-derived products. (566 aa)
ARAC3Rac-like GTP-binding protein ARAC3; Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation. May be involved in cell polarity control during the actin-dependent tip growth of root hairs. SPK1- dependent activation is required for auxin-mediated inhibition of PIN2 internalization during gravitropic responses. (198 aa)
LAC3Laccase-3; Lignin degradation and detoxification of lignin-derived products. (570 aa)
NPR4Regulatory protein NPR4; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways. (574 aa)
LAC10Laccase-10; Lignin degradation and detoxification of lignin-derived products. (558 aa)
TT10Laccase-15; Lignin degradation and detoxification of lignin-derived products (By similarity). Involved in lignin synthesis in seed coats, in seed coat permeability, in seed germination, and in root elongation. Required for the seed coat (testa) brown pigmentation by mediating the polymerization of proanthocyanidin (tannin) from its monomer precursor epicatechin. Slightly promotes seed dormancy. Belongs to the multicopper oxidase family. (565 aa)
NPR3Regulatory protein NPR3; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Involved in the regulation of basal defense responses against pathogens. (586 aa)
LAC11Laccase-11; Lignin degradation and detoxification of lignin-derived products. (557 aa)
BZIP8Basic leucine zipper 8; Belongs to the bZIP family. (138 aa)
RBOHDRespiratory burst oxidase homolog protein D; Calcium-dependent NADPH oxidase that generates superoxide. Involved in the generation of reactive oxygen species (ROS) during incompatible interactions with pathogens and in UV-B and abscisic acid ROS-dependent signaling. Might be required for ROS signal amplification during light stress. Belongs to the RBOH (TC 5.B.1.3) family. (921 aa)
LAC17Laccase-17; Lignin degradation and detoxification of lignin-derived products. (577 aa)
LAC12Laccase-12; Lignin degradation and detoxification of lignin-derived products. (565 aa)
LAC14Laccase-14; Lignin degradation and detoxification of lignin-derived products. (569 aa)
LAC9Laccase-9; Lignin degradation and detoxification of lignin-derived products. (586 aa)
LAC8Laccase-8; Lignin degradation and detoxification of lignin-derived products (By similarity). Involved in the flowering time inhibition. (584 aa)
LAC1Laccase-1; Lignin degradation and detoxification of lignin-derived products. (581 aa)
LAC13Laccase-13; Lignin degradation and detoxification of lignin-derived products. (569 aa)
NPR6Regulatory protein NPR6; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB [...] (467 aa)
SRK2CSerine/threonine-protein kinase SRK2C; Involved in gene regulation and confers tolerance to drought and osmotic stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (343 aa)
LAC5Laccase-5; Lignin degradation and detoxification of lignin-derived products. (580 aa)
LAC7Laccase-7; Lignin degradation and detoxification of lignin-derived products. (567 aa)
NPR2Regulatory protein NPR2; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (600 aa)
LAC6Laccase-6; Lignin degradation and detoxification of lignin-derived products; Belongs to the multicopper oxidase family. (569 aa)
NPR5Regulatory protein NPR5; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB [...] (491 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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