STRINGSTRING
BZR2 BZR2 ABI4 ABI4 ATHB-40 ATHB-40 FRO2 FRO2 FIT FIT IRT1 IRT1 MYB59 MYB59 ATHB-20 ATHB-20 ATHB-13 ATHB-13 PHO1 PHO1 FRO4 FRO4 BEE2 BEE2 TCP8 TCP8 MYB62 MYB62 BIM2 BIM2 MYC3 MYC3 MYB111 MYB111 BIM3 BIM3 HDG11 HDG11 CAMTA1 CAMTA1 BIM1 BIM1 BHLH121 BHLH121 BHLH34 BHLH34 ATHB-53 ATHB-53 ATHB-51 ATHB-51 ORG2 ORG2 ABF2 ABF2 ACS7 ACS7 ERF039 ERF039 RAP2-10 RAP2-10 DOF1.6 DOF1.6 Pit1 Pit1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BZR2Protein BRASSINAZOLE-RESISTANT 2; Positive regulator of brassinosteroid (BR) signaling. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5'-CANNTG-3'(E box) through its N- terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C- terminal domain is probably involved in transcriptional activation. Recruits the transcription elongation factor IWS1 to control BR- regulated gene expression. Forms a trimeric complex with IWS1 and ASHH2/SDG8 to regulate BR-reg [...] (335 aa)
ABI4Ethylene-responsive transcription factor ABI4; Transcription regulator that probably binds to the GCC-box pathogenesis-related promoter element. Binds also to the S-box (5'- CACTTCCA-3') photosynthesis-associated nuclear genes-related (PhANGs- related) promoter element, and thus acts as a transcription inhibitor. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. May have a function in the deetiolation process. Confers sensitivity to abscisic acid (ABA), and regulates the ABA signaling pathway during seed germinatio [...] (328 aa)
ATHB-40Homeobox-leucine zipper protein ATHB-40; Probable transcription factor; Belongs to the HD-ZIP homeobox family. Class I subfamily. (216 aa)
FRO2Ferric reduction oxidase 2; Flavocytochrome that transfers electrons across the plasma membrane to reduce ferric iron chelates to form soluble ferrous iron in the rhizosphere. May be involved in the delivery of iron to developing pollen grains. Acts also as a copper-chelate reductase. Involved in glycine betaine-mediated chilling tolerance and reactive oxygen species accumulation. (725 aa)
FITTranscription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR; Transcription factor. Essential protein involved in iron uptake responses. Regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation. Confers enhanced iron mobilization responses at low iron supply. (318 aa)
IRT1Fe(2+) transport protein 1; High-affinity iron transporter that plays a key role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer. Acts as the principal regulator of iron homeostasis in planta. Also mediates the heavy metals uptake under iron-deficiency by its ability to transport cobalt, cadmium, manganese and/or zinc ions; Belongs to the ZIP transporter (TC 2.A.5) family. (347 aa)
MYB59Transcription factor MYB59; Transcription factor. (235 aa)
ATHB-20Homeobox-leucine zipper protein ATHB-20; Probable transcription factor; Belongs to the HD-ZIP homeobox family. Class I subfamily. (286 aa)
ATHB-13Homeobox-leucine zipper protein ATHB-13; Probable transcription factor that may act in the sucrose- signaling pathway. (294 aa)
PHO1Phosphate transporter PHO1; Inositol polyphosphate sensor that associates with transcription factors to regulate inorganic phosphate (Pi) starvation responses. Probably acts by binding inositol polyphosphate via its SPX domain. Acts as a Pi exporter, mediating efflux of Pi out of cells. Transfers Pi from the epidermal and cortical cells to the root xylem vessels. Involved in the transfer of Pi from roots to shoots. Involved in abscisic acid (ABA) induction of stomatal closure and ABA repression of stomatal opening. Belongs to the SYG1 (TC 2.A.94) family. (782 aa)
FRO4Ferric reduction oxidase 4; Ferric chelate reductase. May participate in the transport of electrons to a Fe(3+) ion via FAD and heme intermediates. May function as root surface cupric chelate reductase and participate in the reduction of Cu(2+), for Cu(+) acquisition via Cu(+) transporters in response to copper deficiency. (699 aa)
BEE2Transcription factor BEE 2; Positive regulator of brassinosteroid signaling. (304 aa)
TCP8Transcription factor TCP8; Can specifically bind site II elements in the promoter region of PP438/PNM1. (401 aa)
MYB62Transcription factor MYB62; Transcription repressor of phosphate (Pi) starvation-induced genes. Regulates negatively Pi starvation responses via the repression of gibberellic acid (GA) biosynthesis and signaling. Modulates root architecture, phosphatase activity, and Pi uptake and accumulation. (286 aa)
BIM2Transcription factor BIM2; Positive brassinosteroid-signaling protein. (311 aa)
MYC3Transcription factor MYC3; Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. (592 aa)
MYB111Transcription factor MYB111; Flavonol-specific transcription activator involved in the regulation of several genes of flavonoid biosynthesis. Activates the expression of CHS, CHI, F3H and FLS1. Controls flavonol biosynthesis primarily in cotyledons and leaves. Confers tolerance to UV-B. (342 aa)
BIM3Transcription factor BIM3; Positive brassinosteroid-signaling protein. (298 aa)
HDG11Homeobox-leucine zipper protein HDG11; Transcription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA. Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth. Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects r [...] (722 aa)
CAMTA1Calmodulin-binding transcription activator 1; Transcription activator that binds calmodulin in a calcium- dependent manner in vitro. Binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3' (By similarity). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance. Involved in freezing tolerance in association with CAMTA2 and CAMTA3. Contributes together with CAMTA2 and CAMTA3 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2. Involved in drought stress responses by regulating several [...] (1007 aa)
BIM1Transcription factor BIM1; Positive brassinosteroid-signaling protein. Transcription factor that bind specifically to the DNA sequence 5'-CANNTG-3'(E box). Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BZR2/BES1. Does not itself activate transcription but enhances BZR2/BES1-mediated target gene activation. (529 aa)
BHLH121Transcription factor bHLH121. (337 aa)
BHLH34Transcription factor bHLH34. (320 aa)
ATHB-53Homeobox-leucine zipper protein ATHB-53; Probable transcription factor that may play a regulatory role in auxin/cytokinin signaling during root development. Belongs to the HD-ZIP homeobox family. Class I subfamily. (228 aa)
ATHB-51Putative homeobox-leucine zipper protein ATHB-51; Putative transcription factor. (235 aa)
ORG2Transcription factor ORG2. (253 aa)
ABF2ABSCISIC ACID-INSENSITIVE 5-like protein 5; Involved in ABA and stress responses and acts as a positive component of glucose signal transduction. Functions as transcriptional activator in the ABA-inducible expression of rd29B. Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter. (416 aa)
ACS71-aminocyclopropane-1-carboxylate synthase 7; 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1- aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene. (447 aa)
ERF039Ethylene-responsive transcription factor ERF039; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity); Belongs to the AP2/ERF transcription factor family. ERF subfamily. (179 aa)
RAP2-10Ethylene-responsive transcription factor RAP2-10; Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity); Belongs to the AP2/ERF transcription factor family. ERF subfamily. (196 aa)
DOF1.6Dof zinc finger protein DOF1.6; Transcription factor that binds specifically to a 5'-AA[AG]G- 3' consensus core sequence. (209 aa)
Pit1RING/FYVE/PHD zinc finger superfamily protein. (218 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.